Study of Molecular Mechanism of Antibiotic susceptibility against Polymicrobial Oral infection

Abstract

Introduction- Antibiotic to treat dental caries infection are routinely prescribed. Bacteria have increased resistance to the currently recommended antibiotics. The purpose of this investigation was to perform antibiotic susceptibility on a panel pathogenic strain of bacteria isolated step by step from dental caries infection. 
Materials and Methods-Bacteria were isolated from caries site of patients and cultivated identified at the species level. Each of 150 species of bacteria was tested for antibiotics susceptibility to a five antibiotics using Etest. Antibiotic used were Amoxicillin, Cloxocillin, Erythromycin, Tetracycline, Penicillin-V.
Results- The percentages of Resistance in treatment for each antibiotic in this study were penicillin V: 72/150 (48%), Tetracycline: 99/150 (66%), amoxicillin: 135/150 (90%), Cloxocillin: 117/150 (78%), and Erythromycin: 90/150 (60%) (Table 1). If combination antibiotic therapy had been used to treat the bacteria isolated from dental caries, the percentage of Resistance for the combination of penicillin V/Amoxicillin would have been 39/150 (26%), and the combination of amoxicillin/ Erythromycin would have been 45/150 (30%).
Conclusion- This study demonstrated the Molecular Mechanism of antibiotic resistance and susceptibility pattern, of bacteria causing dental caries. The comprehensive results data obtained will allow in investigating spatial distribution of pathogenic antibiotic resistant bacteria in patients of dental caries. In turn this will allow the development of novel diagnostic and treatment methods. 
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Is toric duality a Seiberg-like duality in (2+1)-d ?

We show that not all $(2+1)$ dimensional toric phases are Seiberg-like duals. Particularly, we work out superconformal indices for the toric phases of Fanos ${\cal{C}}_3$, ${\cal{C}}_5$ and ${\cal{B}}_2$. We find that the indices for the two toric phases of Fano ${\cal{B}}_2$ do not match, which implies that they are not Seiberg-like duals. We also take the route of acting Seiberg-like duality transformation on toric quiver Chern-Simons theories to obtain dual quivers. We study two examples and show that Seiberg-like dual quivers are not always toric quivers.Comment: 21 pages, 7 figures, to be published in JHE