Nutrigenomics: The science of the 21st century

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Risk factors for the occurrence of cardovascular system diseases in students

Background/Aim. Cardiovascular diseases are a leading cause of death in the majority of developed, as well as in many developing countries. The aim of this study was to determine cardiovascular risk factors in student population and to suggest possible measures for prevention. Methods. The study was carried out during 2007-2008 at the School of Medicine, University of Niš. It included 824 students in their final year (220 males, 604 females). Results. There was no significant difference in prevalence of hypertension among the male (1.81%) and female students (0%). The prevalence of obesity (Body Mass Index - BMI > 30 kg/m2) was significantly higher (p < 0.001) in the male (7.27%) than in the female population (1.32%). Abdominal obesity was also more frequently encountered (p < 0.01) in the male (9.09%) than in female population (1.32%). Every fourth student smoked cigarettes with no significant difference between the male and female students. Alcohol consumption was a significantly higher problem (p < 0.001) in the male population (18.18%) than in the female one (2.65%). Physical inactivity was more often found (p < 0.001) in the female students (65.56%), than in male ones (36.36%). By the bivariate correlation of cardiovascular risk factors, it was determined that in the male student population systolic blood pressure correlated significantly with diastolic blood pressure, BMI and waist size, whereas age correlated with sistolic blood pressure, waist size and smoking. In the female students sistolic blood pressure correlated with diastolic blood pressure, BMI and waist size; diastolic blood pressure correlated with BMI and physical inactivity; cigarette smoking correlated with alcohol consumption and age. Conclusion. Cardiovascular risk factors are present in the final-year students of the School of Medicine, University of Niš. It is necessary to insist on decreasing obesity prevalence, cigarette and alcohol consumption, and on increasing physical activity of students in order to prevent cardiovascular diseases

NUTRITION AND PATIENTS WITH HIV/AIDS

Immune status of an individual depends on the organism’s nutritional status as well as on the choice of nutrients that enter the body. Malnutrition and HIV progression are closely linked and require an active cooperation between infectious disease physicians and nutritionist. It has been noticed that patients with HIV that receive antiretroviral therapy have a significantly greater loss of body weight, and therefore need an adequate diet modification. Oxidative stress represents an important etiological factor in diseases of immune deficiency, so that antioxidant agents (Vitamin A, Vitamin E, Vitamin B12 and certain minerals, such as zinc and selenium) are crucial factors in HIV dietotherapy. Polyphenols from cocoa beans as well as from green and black tea (catechins and teaflavins) have an important role in disease progress modification as well as disease transmission prevention. The patients also need their probiotic intestinal flora to be encouraged to grow properly in order to prevent opportunistic infections. All of these nutrition elements are already in use in prevention, therapy and alleviation of HIV symptoms, and further science development will make a personal diet modification for each patient possible

AIR POLLUTION FROM TRAFFIC AND RESPIRATORY HEALTH

Air pollution has very important influence on human health. Earlier investigations were not employed with estimation of influence of air pollution, which spring from traffic, on people health who live near busy cross – road.The aim of this paper was to determine how living near busy cross – road influences on appearance of respiratory symptoms and illness.400 adult people between 18-76 age who live five year least on this location at took a part in investigation. One group (200) live in Nis near the busiest cross-road, another group live in Niska Banja near cross-road with the smallest concentration of pollutants in last five years.We have determined that examines, who live near busy cross – road had statistical signify greater prevalence of all respiratory symptoms and pneumonia.Our investigation showed that living near busy cross road present risk factor for appearance of respiratory symptoms and pneumonia

Uticaj kosolvenata na etanolizu suncokretovog ulja katalizovanoj kalcijum-oksidom: doktorske disertacije

In this dissertation, the influence of different organic solvents (triethanolamine, diethanolamine, ethylene glycol, methyl ethyl ketone, n-hexane, triethylamine, ethylene glycol dimethyl ether, glycerol, tetrahydrofuran and dioxane) as cosolventethanolysis of sunflower oil catalyzed by calcinated CaO. Ethanolysis was performed as a heterogeneous base-catalyzed process in which calcinated CaO in a stirred batch reactor was used as a catalyst. The reaction conditions were: temperature 70 °C, ethanol:oil molar ratio 12:1, catalyst concentration 1.374 mol·dm-3 and cosolvent amount 20% by weight of oil. Without cosolvent, the reaction is relatively slow, because the EEMK content of 89.7 ± 1.73% was obtained only after 4 h of reaction. Of the cosolvents used, only diethanolamine, triethanolamine and ethylene glycol had a positive effect on the rate of ethanolysis reaction, with the use of triethanolamine and ethylene glycol achieved the highest EEMK content of 93.1±2.1 and 94.1± 1.5%, respectively, after 0,5 h reaction. Based on the experimental results, triethanolamine and the cosolvent that had the greatest positive effect on the rate of the transesterification reaction of the safety profile were selected, triethanolamine was selected as the best cosolvent of the reaction ethanolysis reaction catalyzed by CaO. The reaction with triethanolamine was optimized with respect to temperature (61,6-78,4 °C), ethanol:oil molar ratio (7:1-17:1) and cosolvent amount (3-36%, by weight of oil) using a central composite rotatable experimental design (RCCD) in combination with a response surface methodology (RSM). The optimal reaction conditions are: molar ratio ethanol:oil 9:1, temperature 75 °C and cosolvent amount 30% ( to the mass of oil), where the predicted value of EEMK content after only 20 min of reaction was 98,8%, while the experimentally obtained value was 97,9 ± 1,3%. High EEMK contents were also obtained during the application of expired sunflower oil, hemp oil and waste lard. X-ray diffraction analysis (XRD) was used to understand the structural changes of CaO catalysts. The CaO catalyst could be used without any additional treatment in two consecutive cycles. Due to the leaching of calcium into the product, an additional purification process must be included in the entire production process

NUTRITIVE THERAPY OF HEPATIC ENCEPHALOPATHY AS A COMPLICATION OF LIVER CIRRHOSIS

Hepatic encephalopathy is a complication of liver cirrhosis and is defined as a neuropsychiatric disease, with a reversibile character. Besides classical ways of therapy, an increasing importance is attached to nutritional therapy that is an effective prevention of the onset and leads to an ease of symptoms in hepathic encephalopathy that already exists. After the patient's nutritional status evaluation, the prescription of diet that includes adequate protein, calories and vitamins is assessed. The greatest importance is attached to the zinc intake as well as branched chain amino acids (BCAA therapy) supplementation. It is believed that further development of science in terms of nutrigenomics and nutrigenetics will give detailed guidance on further developments since the possibility of clinical investigation in these patients is limited

Prisustvo potencijalno toksigenih gljiva u hrani za živinu

In Serbia, commercial feedstuffs are an important component in modern animal husbandry, but there is no information available about fungal contamination. Because of that the aim of this study was to determine the mycoflora incidence in poultry feeds. A total of 230 samples of poultry feeds were examined for total fungi count and the presence of potential toxigenic fungi genera. Total fungi count were 1-9 x 104 CFU g-1 in the most of investigated poultry feed samples (38.26%). The most prevalent fungi genera were Fusarium (56.09%) and Aspergillus (54.35%), followed by Rhizopus (40%), Penicillium (30.87%), Mucor (30.04%) and the least frequency species were from genus Alternaria (3.48%).U Srbiji komercijalna hrana za životinje je važna komponenta u savremenom stočarstvu, ali nema dostupnih informacija o kontaminiranosti ove hrane gljivama. Zbog toga cilj ovoga rada je bio određivanje sastava mikoflore u hrani za živinu. U ukupno 230 uzoraka hrane za živinu proučavani su ukupan broj gljiva i prisustvo potencijalno toksigenih rodova gljiva. U većini proučavanih uzoraka hrane za živinu (38.26%) ukupan broj gljiva bio je od 1-9 x 104 CFU g-1. Najzastupljeniji rodovi gljiva bili su Fusarium (56.09%) i Aspergillus (54.35%), zatim slede Rhizopus (40%), Penicillium (30.87%), Mucor (30.04%) a najmanje zastupljene vrste gljiva bile su iz roda Alternaria (3.48%)

Maternal smoking during pregnancy and socioeconomic factors as predictors of low birth weight in term pregnancies in Niš

Background/Aim. Low birth weight (LBW) is a result of preterm birth or intrauterine growth retardation, and in both cases is the strongest single factor associated with perinatal and neonatal mortality. It is considered that socioeconomic factors, as well as mothers bad habits, play the most significant role in the development of LBW, which explains notable number of researches focused on this particular problem. The aim of this study was to characterize socioeconomic factors, as well as smoking habits of the mothers, and their connection with LBW. Methods. The questionnaire was carried out among mothers of 2 years old children (n = 956), born after 37 gestational weeks. The characteristics of mothers who had children with LBW, defined as < 2 500 g, (n = 50), were matched with the characteristics of mothers who had children ≥ 2 500 g, (n = 906). For defining risk factors, and protective factors as well, we used univariant and multivariant logistic modeles. Results. As significant risk factors for LBW in an univariant model we had education level of the mothers, smoking during pregnancy, smoking before pregnancy, the number of daily cigarettes, the number of cigarettes used during pregnancy, paternal earnings and socioeconomic factors. In a multivariant model the most significant factors were socioeconomic factors, education level of the mothers, paternal earnings and mothers smoking during pregnancy. Conclusion. Smoking during pregnancy and socioeconomic factors have great influence on LBW. Future studies should be carried out in different social groups, with the intention to define their influence on LBW and reproduction, as well. This should be the proper way of adequate health breeding planning for giving up smoking, the prevention of bad habits and melioration of mothers and children health, as the most vulnerable population

Authentication of meat and meat products vs. detection of animal species in feed - what is the difference?

Authenticity of food is an issue that is growing in awareness and concern. Although food adulteration has been present since antiquity, it has broadened to include entire global populations as modern food supply chains have expanded, enriched and become more complex. Different forms of adulteration influence not only the quality of food products, but also may cause harmful health effects. Meat and meat products are often subjected to counterfeiting, mislabelling and similar fraudulent activities, while substitutions of meat ingredients with other animal species is one among many forms of food fraud. Feed is also subject to testing for the presence of different animal species, but as part of the eradication process of transmissible spongiform encephalopathies (TSE). In both food and feed cases, the final goal is consumer protection, which should be provided by quick, precise and specific tools. Several analytical tests have been employed for such needs. This paper provides an overview of authentication of meat and meat products compared with species identification in feed control, highlighting the most prevalent laboratory methods

Choline chloride-based deep eutectic solvents in CaO-catalyzed ethanolysis of expired sunflower oil

Choline chloride (ChCl)-based deep eutectic solvents (DESs) with different amides or polyols as hydrogen bond donors were tested as cosolvents in the ethanolysis of expired sunflower oil catalyzed by either calcined or non-calcined CaO. These cosolvents promoted the ethanolysis by a successful activation of non-calcined CaO, which was ascribed to the CaCO3 and Ca(OH)2 dissolution from the surface of the solid catalyst particles. With both calcined and non-calcined CaO, the polyol-based solvents gave higher fatty acid ethyl esters (FAEE) content than the amide-based solvents. Among the amide-based DESs, choline chloride:urea (ChCl:U) was the most efficient activator of non-calcined CaO. Choline chloride:ethylene glycol (ChCl:EG) and choline chloride:propylene glycol (ChCl:PG) were more efficient than choline chloride:glycerol (ChCl:G) even with non-calcined CaO. However, ChCl:G might be more suitable than the others since the use of glycerol, a by-product of the ethanolysis, could reduce the overall biodiesel production costs. FTIR and XRD analyses of the used and separated CaO were performed in order to get more insight into the catalytically active phase(s). Also, the mechanisms of the CaO activation in the presence of the DESs were considered. The phase separation of the reaction mixture was faster in the presence of the DESs. Since ChCl:U and ChCl:G DESs are nontoxic, biodegradable, biorenewable and “green” solvents and provide the elimination of the calcination step of CaO, thus reducing the overall process costs, the non-calcined CaO catalytic systems with these DESs are recommended for further optimization. © 2018 Elsevier B.V.Published version: [https://hdl.handle.net/21.15107/rcub_dais_3694]This is the peer reviewed version of the following article: Troter, D.Z., Todorović, Z.B., Đokić-Stojanović, D.R., Veselinović, L.M., Zdujić, M.V., Veljković, V.B., 2018. Choline chloride-based deep eutectic solvents in CaO-catalyzed ethanolysis of expired sunflower oil. Journal of Molecular Liquids 266, 557–567. [https://doi.org/10.1016/j.molliq.2018.06.106]Supplementary information: [https://hdl.handle.net/21.15107/rcub_dais_3772