6 research outputs found

    Способы перевода димензиональной лексики

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    Огромным достоянием человечества является число. Зарождение и развитие категории числа, нашло реализацию в языке, отражает этапы становления абстрактного мышления человека. Истоки возникновения понятия числа достигают древнейших времен существования человечества и связанные в своей основе с соответствующими этапами познания человеком окружающей его действительности При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/3444

    THE EFFECT OF SILENCE IN ENGLISH ART DISCOURSE

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    The article is connected with problems of complex analysis of the silence effect and its aspects observed in communicative and non-communicative silence and examined on the basis of materials of the English artistic discourse

    Силенціальний ефект в художньому дискурсі Ч. Діккенса

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    Статтю присвячено комплексному аналізу силенціального ефекту та його аспектів, що есплікується у термінах мовленнєвих ситуацій силенціальних лакун в художньому дискурсі Ч. Діккенса,емпірична база якого вельми валідна. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/29891The article deals with complex analysis of silential effect and its aspects, which are explicated in terms of silence speech situations in Dikkens's works. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/2989

    Sweet-Tasting Natural Proteins Brazzein and Monellin: Safe Sugar Substitutes for the Food Industry

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    This article presents the results of a comprehensive toxicity assessment of brazzein and monellin, yeast-produced recombinant sweet-tasting proteins. Excessive sugar consumption is one of the leading dietary and nutritional problems in the world, resulting in health complications such as obesity, high blood pressure, and cardiovascular disease. Although artificial small-molecule sweeteners widely replace sugar in food, their safety and long-term health effects remain debatable. Many sweet-tasting proteins, including thaumatin, miraculin, pentadin, curculin, mabinlin, brazzein, and monellin have been found in tropical plants. These proteins, such as brazzein and monellin, are thousands-fold sweeter than sucrose. Multiple reports have presented preparations of recombinant sweet-tasting proteins. A thorough and comprehensive assessment of their toxicity and safety is necessary to introduce and apply sweet-tasting proteins in the food industry. We experimentally assessed acute, subchronic, and chronic toxicity effects, as well as allergenic and mutagenic properties of recombinant brazzein and monellin. Our study was performed on three mammalian species (mice, rats, and guinea pigs). Assessment of animals’ physiological, biochemical, hematological, morphological, and behavioral indices allows us to assert that monellin and brazzein are safe and nontoxic for the mammalian organism, which opens vast opportunities for their application in the food industry as sugar alternatives

    A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity

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    <div><p>YciH is a bacterial protein, homologous to eukaryotic translation initiation factor eIF1. Preceding evidence obtained with the aid of <i>in vitro</i> translation initiation system suggested that it may play a role of a translation initiation factor, ensuring selection against suboptimal initiation complexes. Here we studied the effect of <i>Escherichia coli yciH</i> gene inactivation on translation of model mRNAs. Neither the translation efficiency of leaderless mRNAs, nor mRNAs with non AUG start codons, was found to be affected by YciH <i>in vivo</i>. Comparative proteome analysis revealed that <i>yciH</i> gene knockout leads to a more than fold2- increase in expression of 66 genes and a more than fold2- decrease in the expression of 20 genes. Analysis of these gene sets allowed us to suggest a role of YciH as an inhibitor of translation in a stress response rather than the role of a translation initiation factor.</p></div
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