256 research outputs found

    West Virginia

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    Experience in Social Affective Applications: Methodologies and Case Study

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    New forms of social affective applications are emerging, bringing with them challenges in design and evaluation. We report on one such application, conveying well-being for both personal and group benefit, and consider why existing methodologies may not be suitable, before explaining and analyzing our proposed approach. We discuss our experience of using and writing about the methodology, in order to invite discussion about its suitability in particular, as well as the more general need for methodologies to examine experience and affect in social, connected situations. As these fields continue to interact, we hope that these discussions serve to aid in studying and learning from these types of application

    A Comparison of the Photographs in the \u3cem\u3eMilwaukee Journal\u3c/em\u3e, the \u3cem\u3eMilwaukee Sentinel\u3c/em\u3e and the \u3cem\u3eWisconsin News\u3c/em\u3e for One Week Before the Wirephoto and for One Week After the Wirephoto

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    The object of this thesis is to survey all three metropolitan newspapers of Milwaukee to ascertain what has been the effect of the wirephoto upon the Milwaukee Journal, The Milwaukee Sentinel and the Wisconsin News, and also to discover what can be done by a newspaper without the use of the wirephoto to overcome the effects of the wirephoto upon the readers

    Designing for Schadenfreude (or, how to express well-being and see if you're boring people)

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    This position paper presents two studies of content not normally expressed in status updates—well-being and status feedback—and considers how they may be processed, valued and used for potential quality-of-life benefits in terms of personal and social reflection and awareness. Do I Tweet Good? (poor grammar intentional) is a site investigating more nuanced forms of status feedback than current microblogging sites allow, towards understanding self-identity, reflection, and online perception. Healthii is a tool for sharing physical and emotional well-being via status updates, investigating concepts of self-reflection and social awareness. Together, these projects consider furthering the value of microblogging on two fronts: 1) refining the online personal/social networking experience, and 2) using the status update for enhancing the personal/social experience in the offline world, and considering how to leverage that online/offline split. We offer results from two different methods of study and target groups—one co-workers in an academic setting, the other followers on Twitter—to consider how microblogging can become more than just a communication medium if it facilitates these types of reflective practice

    Can the Revised UK Code Direct Practice?

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    The Nursing and Midwifery Council, the United Kingdom regulator of nursing and midwifery has recently revised its professional code of practice. This paper begins by arguing that a professional code must be capable of sustaining close reading and of action guidance. Using four exemplar clauses it is argued that the new revised code does not met this purpose. First, I show that in setting out requirements for consent and documentation, the meaning of the relevant clause has changed significantly during the editing process so that a literal reading of the final document bears little relation to established professional practice. Second, I argue that the clause concerning the nature of professional relationships has also been altered during the editing process so that it is inconsistent with other professional groups and established accounts of the professional nurse-patient relationship. Third, I argue that the clause concerning disclosure of confidential information, which survived revision and editing with its meaning intact is nevertheless factually incorrect and inconsistent with UK law and authoritative guidance. Finally, fourth, I argue that use of the word ‘inappropriate’ is inappropriate as it amounts to meaningless circularity, discussed in relation to a clause on expressing personal beliefs. Taken together, these examples demonstrate that the Code is seriously flawed and does not fulfil its purpose. One way that simple prescriptive clauses in the Code can be usefully understood is through the provision of detailed guidance. I argue that the NMC has changed its position on its view of the value of guidance and has significantly reduced the amount of written guidance and advice is provides. The paper concludes by arguing that in order to meet its action directing function, further clarifying revision and the provision of detailed guidance is required

    Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst.

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    The tissue cyst formed by the bradyzoite stage of Toxoplasma gondii is essential for persistent infection of the host and oral transmission. Bradyzoite pseudokinase 1 (BPK1) is a component of the cyst wall, but nothing has previously been known about its function. Here, we show that immunoprecipitation of BPK1 from in vitro bradyzoite cultures, 4 days postinfection, identifies at least four associating proteins: MAG1, MCP4, GRA8, and GRA9. To determine the role of BPK1, a strain of Toxoplasma was generated with the bpk1 locus deleted. This BPK1 knockout strain (Δbpk1) was investigated in vitro and in vivo. No defect was found in terms of in vitro cyst formation and no difference in pathogenesis or cyst burden 4 weeks postinfection (wpi) was detected after intraperitoneal (i.p.) infection with Δbpk1 tachyzoites, although the Δbpk1 cysts were significantly smaller than parental or BPK1-complemented strains at 8 wpi. Pepsin-acid treatment of 4 wpi in vivo cysts revealed that Δbpk1 parasites are significantly more sensitive to this treatment than the parental and complemented strains. Consistent with this, 4 wpi Δbpk1 cysts showed reduced ability to cause oral infection compared to the parental and complemented strains. Together, these data reveal that BPK1 plays a crucial role in the in vivo development and infectivity of Toxoplasma cysts

    Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79

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    Herpes simplex virus 1 (HSV-1) is a widespread global pathogen, of which the strain KOS is one of the most extensively studied. Previous sequence studies revealed that KOS does not cluster with other strains of North American geographic origin, but instead clustered with Asian strains. We sequenced a historical isolate of the original KOS strain, called KOS63, along with a separately isolated strain attributed to the same source individual, termed KOS79. Genomic analyses revealed that KOS63 closely resembled other recently sequenced isolates of KOS and was of Asian origin, but that KOS79 was a genetically unrelated strain that clustered in genetic distance analyses with HSV-1 strains of North American/European origin. These data suggest that the human source of KOS63 and KOS79 could have been infected with two genetically unrelated strains of disparate geographic origins. A PCR RFLP test was developed for rapid identification of these strains

    Explicating "Implicit Interaction" : An Examination of the Concept and Challenges for Research

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    The term implicit interaction is often used to denote interactions that differ from traditional purposeful and attention demanding ways of interacting with computers. However, there is a lack of agreement about the term's precise meaning. This paper develops implicit interaction further as an analytic concept and identifies the methodological challenges related to HCI's particular design orientation. We first review meanings of implicit as unintentional, attentional background, unawareness, unconsciousness and implicature, and compare them in regards to the entity they qualify, the design motivation they emphasize and their constructive validity for what makes good interaction. We then demonstrate how the methodological challenges can be addressed with greater precision by using an updated, intentionality-based definition that specifies an input-effect relationship as the entity of implicit. We conclude by identifying a number of new considerations for design and evaluation, and by reflecting on the concepts of user and system agency in HCI.Peer reviewe

    6918 Determining potential: onshore/offshore prehistory

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    Historic England commissioned a team from the University of Southampton to undertake project 6918, ‘Determining Potential: onshore/offshore prehistory’ between January 2014 and July 2015. The central focus of the research was on evaluating methods that might be used to help move from generic to more specific understandings of archaeological potential within such environs. A region of the Bristol Channel and Somerset Levels was chosen as the study area within which to carry out this work, due to its already noted high potential for contributing to our understanding of prehistory. Three overarching aims were given for the project: a. Assess the efficacy of predictive modelling for the determination of the potential for submerged prehistoric archaeology in English waters;b. Evaluate the range of methods open to archaeologists when assessing the potential for submerged prehistoric archaeology offshore, and how best to investigate/mitigate for it; andc. Extend our knowledge of key inter-tidal and offshore sequences in a region already known for its nationally significant inter-tidal and onshore prehistoric record.This monograph describes three different approaches to modelling potential: inductive, deductive and geoarchaeological. The conclusion is reached that inductive predictive modelling is currently an inappropriate method for improving our understanding of offshore potential (and in some instances deeply buried onshore locations) in England. This is due to low data density and high degrees of uncertainty with regard to prehistoric activity. Deductive and geoarchaeologically focused methods were found to hold much greater promise for determining potential. However, again the need for high quality input data was highlighted. All of the above approaches should be seen as iterative in nature, and require a commitment to improving data accessibility and joined up approaches to acquisition. It also requires a greater degree of communication with colleagues working in countries whose territorial waters directly abut England’s.The above recognition of the need to improve our baseline understanding of both palaeoenvironmental change and archaeological finds density is one of the most significant and challenging outcomes from this project. In carrying out the review to address point b above, and the fieldwork to address point c, it became clear that we need to sample larger volumes across a wider range of ecological niches. Put simply, without adopting methods that maximise the chance of recovering material culture offshore we will never be able to:1. Answer key research questions identified in regional and national research agendas that are pertinent to both the onshore and offshore archaeological record.2. Improve our ability to pinpoint areas likely to produce important finds.The lack of direct engagement offshore, the limited nature of inter-tidal investigations and the uneven distribution of commercial activity onshore has led to a record that is hard to interpret with regard to the specifics of potential, beyond discussion in the broadest terms. Rather than being a negative outcome this is seen to be a positive result. The act of creating a deductive model forced detailed analysis of the qualities of input data, and highlighted lacunae in our understanding. In ground-truthing the deductive model new information was generated that contributes to our growing appreciation of the complexities of environmental change across the study region, and areas in need of future research clearly identified. Finally, through accepting that we may not be able to answer questions we have already raised of the offshore record without a change in approach, this research establishes the urgent need for more detailed consideration of how we manage and carry out research into the submerged prehistoric record, as well as compiling and distributing these results
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