Cloud for Gaming

Cloud for Gaming refers to the use of cloud computing technologies to build large-scale gaming infrastructures, with the goal of improving scalability and responsiveness, improve the user's experience and enable new business models.Comment: Encyclopedia of Computer Graphics and Games. Newton Lee (Editor). Springer International Publishing, 2015, ISBN 978-3-319-08234-

6th-order finite volume approximation for the steady-state burger and euler equations: the mood approach

We propose an innovative method based on the MOOD technology (Multi-dimensional Optimal Order Detection) to provide a 6th-order finite volume approximation for the one-dimensional steady-state Burger and Euler equations. The main ingredient consists in using an 'a posteriori' limiting strategy to eliminate non physical oscillations deriving from the Gibbs phenomenon while keeping a high accuracy for the smooth part. A short overview of the MOOD method will be presented and numerical tests with regular or discontinuous solutions will assess the method capacity to produce excellent approximations. In the latter situation, the numerical results enable to detect the zone where it is necessary to reduce the degree of the polynomial reconstructions to preserve the scheme robustness.Fundação para a Ciência e a Tecnologia (FCT

A Pragmatic Definition of Elephants in Internet Backbone Traffic

Studies of the Internet traffic at the level of network prefixes, fixed length prefixes, TCP flows, AS’s, and WWW traffic, have all shown that a very small percentage of the flows carries the largest part of the information. This behavior is commonly referred to as “the elephants and mice phenomenon”. Traffic engineering applications, such as re-routing or load balancing, could exploit this property by treating elephant flows differently. In this context, though, elephants should not only contribute significantly to the overall load, but also exhibit sufficient persistence in time. The challenge is to be able to examine a flow’s bandwidth and classify it as an elephant based on the data collected across all the flows on a link. In this paper, we present a classification scheme that is based on the definition of a separation threshold, that elephants have to exceed. We introduce two single-feature classification schemes, and show that the resulting elephants are highly volatile. We then propose a two-feature classification scheme that incorporates temporal characteristics and show that this approach is more successful in isolating elephants that exhibit consistency thus making them more attractive for traffic engineering applications

High efficiency symmetric beam splitter for cold atoms with a standing wave light pulse sequence

In a recent experiment [1], it was observed that a sequence of two standing wave square pulses can split a BEC at rest into +/- 2 h_bar k diffraction orders with almost 100% efficiency. By truncating the Raman-Nath equations to a 2-state model, we provide an intuitive picture that explains this double square pulse beamsplitter scheme. We further show it is possible to optimize a standingwave multi square pulse sequence to efficiently diffract an atom at rest to symmetric superposition of +/- 2n h_bar k diffraction order with n>1. The approach is considered to be qualitatively different from the traditional light pulse schemes in the Bragg or the Raman-Nath region, and can be extended to more complex atomic optical elements that produce various tailored output momentum states from a cold atom source.Comment: 22 pages, 4 figures, 1 tabl

Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorrhagic Escherichia coli infections

Enterohemorrhagic Escherichia coli (EHEC) are food-borne pathogens that can cause serious infections ranging from diarrhea to hemorrhagic colitis (HC) and hemolytic-uremic syndrome (HUS). Translocation of Shiga-toxins (Stx) from the gut lumen to underlying tissues is a decisive step in the development of the infection, but the mechanisms involved remain unclear. Many bacterial pathogens target the follicle-associated epithelium, which overlies Peyer's patches (PPs), cross the intestinal barrier through M cells and are captured by mucosal macrophages. Here, translocation across M cells, as well as survival and proliferation of EHEC strains within THP-1 macrophages were investigated using EHEC O157:H7 reference strains, isogenic mutants, and 15 EHEC strains isolated from HC/HUS patients. We showed for the first time that E. coli O157:H7 strains are able to interact in vivo with murine PPs, to translocate ex vivo through murine ileal mucosa with PPs and across an in vitro human M cell model. EHEC strains are also able to survive and to produce Stx in macrophages, which induce cell apoptosis and Stx release. In conclusion, our results suggest that the uptake of EHEC by M cells and underlying macrophages in the PP may be a critical step in Stx translocation and release in vivo. A new model for EHEC infection in humans is proposed that could help in a fuller understanding of EHEC-associated diseases

Identifiability of flow distributions from link measurements with applications to computer networks

We study the problem of identifiability of distributions of flows on a graph from aggregate measurements collected on its edges. This is a canonical example of a statistical inverse problem motivated by recent developments in computer networks. In this paper (i) we introduce a number of models for multi-modal data that capture their spatio-temporal correlation, (ii) provide sufficient conditions for the identifiability of nth order cumulants and also for a special class of heavy tailed distributions. Further, we investigate conditions on network routing for the flows that prove sufficient for identifiability of their distributions (up to mean). Finally, we extend our results to directed acyclic graphs and discuss some open problems.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58107/2/ip7_5_004.pd

Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C

Niemann–Pick disease type C (NPC) is a rare lysosomal storage disease caused by mutations in either the NPC1 or NPC2 genes. Mutations in the NPC1 gene lead to the majority of clinical cases (95%); however, the function of NPC1 remains unknown. To gain further insights into the biology of NPC1, we took advantage of the homology between the human NPC1 protein and its yeast orthologue, Niemann–Pick C–related protein 1 (Ncr1). We recreated the NCR1 mutant in yeast and performed screens to identify compensatory or redundant pathways that may be involved in NPC pathology, as well as proteins that were mislocalized in NCR1-deficient yeast. We also identified binding partners of the yeast Ncr1 orthologue. These screens identified several processes and pathways that may contribute to NPC pathogenesis. These included alterations in mitochondrial function, cytoskeleton organization, metal ion homeostasis, lipid trafficking, calcium signalling, and nutrient sensing. The mitochondrial and cytoskeletal abnormalities were validated in patient cells carrying mutations in NPC1, confirming their dysfunction in NPC disease

Aérosols de médicaments

L\u27aérosolthérapie a bénéficié ces dernières années de progrès technologiques considérables au niveau des générateurs d\u27aérosols. Les aérosols doseurs liquides HFA avec ou sans chambre d\u27inhalation, les aérosols doseurs de poudre ont vu leurs indications respectives précisées. Les systèmes de nébulisation ont également progressé avec notamment l\u27apparition des nébuliseurs à membranes. La nébulisation permet de traiter les formes les plus sévères des maladies repiratoires, asthme, BPCO, mucoviscidose, par les bronchodilatateurs, les corticoïdes, les antibiotiques et la rhDNase I. L\u27utilisation de la nébulisation trouve depuis peu des applications pour le traitement de maladies systémiques telles que le diabète ou l\u27hypertension artérielle pulmonaire. Des perspectives apparaissent également pour la chimiothérapie antitumorale et la vaccination par aérosols. Les conditions optimales de prescription, d\u27administration et de suivi de l\u27aérosolthérapie ont été définies