Is oral lornoxicam effective in the treatment of acute migraine attacks? : a randomized-controlled study

The aim of this study was to assess the efficacy of lornoxicam (LNX) in the treatment of acute migraine attacks. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial was conducted administering either LNX or placebo to patients who were diagnosed with migraine without aura according to the International Headache Society (the year 2004) criteria between 2010 and 2012 Results: Of 44 patients with 120 migraine attacks, 38 were female and rest were males. Mean age was 37.75 ± 9.28 years. Patients recorded using LNX in 87 migraine attacks and placebo in 33 migraine attacks, respectively. Pain intensity scores of the patients were found similar between LNX and placebo groups, statistically. Conclusion: Although oral LNX was found to have efficacy similar to placebo statistically in the treatment of acute migraine attacks, further studies are needed to evaluate appropriately the efficacy of LNX for treatment of acute migraine attacks

Craniocervical Pains

Craniocervical pains can be analyzed in two groups: cranial neuralgias and cervicogenic pains. Cranial neuralgias are with neuropathic character; however, their etiologies might be atypical, idiopathic and psychogenic. Generally, it can be experienced as one-sided lightning strikes, electric shock-like and stabbing pain. The paroxysmal pains originate from nerves with somatic afferent fibers, such as trigeminal, facial, glossopharingeal, vagus, and also sometimes from the C2-3 dorsal roots. Moreover, the most commonly seen are trigeminal neuralgias. Cervicogenic pains are caused by cervical spinal nerves, pathologies of the structure of the cervical intervertebral disc, cervical facet joints and the soft tissue of these areas. Turk J Phys Med Rehab 2010;56 Suppl 1:38-45

Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is still a poorly understood disorder which pathophysiological mechanisms include the autonomic, sensory and motor systems as well as cortical areas involved in the processing of cognitive and affective information. The main CRPS clinical symptoms are pain and hyperalgesia, vasomotor, sudomotor and trophic changes in the affected extremity. In addition, motor symptoms are usually present from the beginning, and may progress with ongoing duration. CRPS patients exhibit changes that occur in somatosensory systems processing noxious, tactile and thermal information, in sympathetic systems innervating skin (blood vessels, sweat glands) and in the somatomotor system. The most common approach to the treatment of CRPS combines sequential trials of analgesic drugs with rehabilitative and psychological interventions. Invasive techniques like sympathetic blocks, spinal cord stimulation, etc. have limited roles in CRPS. (Archives of Neuropsychiatry 2009; 46: 70-5

Palliative Care in Lung Cancer

The Lung cancer rate in all cancer types is 21% in men and 5 % in women in European Union Countries. Smoking is the most important factor of lung cancer etiology [1]. The rate of Turkey is found 63% in men and 14% in women in 1988. 88.7% of the patients in Turkey have got smoking story. Lung cancer risk increases 3.5 times in passive smoking. Because there are carcinogens in air and they are not filtered; therefore, they are denser on air [2]

Plot tab of the MLViS web-tool.

<p>A dendrogram and a heat map can be created based on the compounds’ molecular similarity.</p

Performance assessment of various statistical learning algorithms in virtual screening of compounds.

<p>AR: Accuracy rate, SE: Sensitivity, SP: Specificity, PPV: Positive predictive value, NPV: Negative predictive value, DR: Detection rate, bAR: Balanced accuracy rate,</p><p>FS: F score, MCC: Matthews correlation coefficient, κ: Kappa statistic. Bold values indicate the top three winner algorithms in each performance measure</p><p>Performance assessment of various statistical learning algorithms in virtual screening of compounds.</p

PubChem tab of the MLViS web-tool.

<p>Users can create and view molecular structures of compounds.</p