Variations of customary tenure, chiefly power, and global norms for responsible land investments in Sierra Leone

In response to debates around land grabbing, the international community has increasingly developed and promoted global governance norms and guidelines for more responsible land investments. This concern on the part of the international community has particularly taken hold in Sierra Leone—in a post-war context, in which international donor agencies are already steering much of the country’s politics. Yet, despite the enormous influence of international guidelines and the actors promoting their use, there is a spatial variation in the conformity to and effectiveness of such norms in cases of land investments. While some projects seem to resemble ‘showcases’ for their exemplary use, these guidelines seem to be absent in other projects. This article analyses the political economy of customary land tenure, land investments, and international ‘soft laws’ in Sierra Leone. Based on 6 months of fieldwork in Sierra Leone in 2019, I compare several cases of large-scale land investments. I argue that there are important variations in the customary tenure system in the degree to which political authority over land is centralized in the authority of the paramount chief or is devolved to landholding families. This, I suggest, holds important implications for the uptake of global norms for ‘responsible’ investments

Global governance meets local land tenure: international codes of conduct for responsible land investments in Uganda

Throughout the last decade, the international donor community has developed a plethora of regulatory initiatives for responsible agricultural investments. It remains unclear how such guidelines are invoked in practice in investment cases, and whether their use can prevent conflict and protect local land rights, as promoted. Uncovering how international guidelines work necessitates an understanding of the formal-legal setting and underlying land tenure regimes that shape investment projects. In Uganda, these contexts vary from region to region and investments take place on land held under various tenure regimes, including private, state-owned, and customary land. Based on 8 months of fieldwork in Uganda, I compare three cases of large-scale land investments in different settings and argue that variation in the underlying land tenure systems determines the variation, uneven applicability and effectiveness of global governance mechanisms

What crop theft in northern Uganda tells us about relations between investors and communities

In the Acholi sub-region of northern Uganda, commercial farmers are experiencing an increasing theft of maize. Arthur Owor and Carolin Dieterle explore the underlying reasons for this and draw attention to the need for more meaningful collaboration between investors and host communities

Governing land investments: global norms, local land tenure regimes, and domestic contingencies in Uganda and Sierra Leone

Following the outcry and fierce debates around ‘land grabbing’ in relation to the rise of foreign transnational large-scale land investments in the Global South since 2007, a plethora of international regulatory initiatives and global norms have emerged with the aim to make such investments more responsible and socially and environmentally sustainable. It remains unclear how and when such guidelines are invoked in practice in investment cases, and whether their use can prevent land conflict and protect local land rights as human rights, as promoted. This PhD project studies the conditions under which global norms for responsible investments may gain traction in cases of large-scale land investments in two different country contexts, Uganda and Sierra Leone. What accounts for the uneven invocation and use of international guidelines in addressing local land conflict? Much literature perceives of the idea of global norms to safeguard land rights in cases of large-scale land investments as deeply flawed and sees them as global governance tools to promote and justify neoliberal principles of privatisation, commodification and land appropriation. My research offers a more variegated picture. In line with theories of human rights norms implementation that finds that such norms tend to be adopted when local conditions are receptive, I draw attention to the important role of and variation in local land governance institutions and contingencies in shaping the extent to which and how such global norms gain traction in cases of large-scale land investments. The analysis focuses on (1) the prevailing land tenure regimes, (2) the stakes of the national government in investment projects, and (3) the ‘strength’ of the government vis-à-vis the international community. These three dimensions, I argue, are interlinked and vary at the subnational level, thus accounting for the uneven ways in which global norms are implemented

What land governance in Uganda can teach us about #PublicAuthority

Carolin Dieterle investigates the how, when and where of large-scale land investments in Uganda. This article is part of the #PublicAuthority blog series, part of the ESRC-funded Centre for Public Authority and International Development

Metabolomic serum abnormalities in dogs with hepatopathies

Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic shunts (cPSS, n = 24) or high serum liver enzyme activities (HLEA, n = 25) compared to control dogs (n = 64). A validated targeted proton nuclear magnetic resonance spectroscopy platform was used to assess 123 parameters. Principal component analysis of the serum metabolome demonstrated distinct clustering among individuals in each group, with the cluster of HLEA being broader compared to the other groups, presumably due to the wider spectrum of hepatic diseases represented in these samples. While younger and older adult control dogs had very similar metabolomic patterns and clusters, there were changes in many metabolites in the hepatopathy groups. Higher phenylalanine and tyrosine concentrations, lower branched-chained amino acids (BCAAs) concentrations, and altered fatty acid parameters were seen in cPSS dogs compared to controls. In contrast, dogs with HLEA had increased concentrations of BCAAs, phenylalanine, and various lipoproteins. Machine learning based solely on the metabolomics data showed excellent group classification, potentially identifying a novel tool to differentiate hepatopathies. The observed changes in metabolic parameters could provide invaluable insight into the pathophysiology, diagnosis, and prognosis of hepatopathies.Peer reviewe

Metabolomic Abnormalities in Serum from Untreated and Treated Dogs with Hyper- and Hypoadrenocorticism

The adrenal glands play a major role in metabolic processes, and both excess and insufficient serum cortisol concentrations can lead to serious metabolic consequences. Hyper- and hypoadrenocorticism represent a diagnostic and therapeutic challenge. Serum samples from dogs with untreated hyperadrenocorticism (n = 27), hyperadrenocorticism undergoing treatment (n = 28), as well as with untreated (n = 35) and treated hypoadrenocorticism (n = 23) were analyzed and compared to apparently healthy dogs (n = 40). A validated targeted proton nuclear magnetic resonance (H-1 NMR) platform was used to quantify 123 parameters. Principal component analysis separated the untreated endocrinopathies. The serum samples of dogs with untreated endocrinopathies showed various metabolic abnormalities with often contrasting results particularly in serum concentrations of fatty acids, and high- and low-density lipoproteins and their constituents, which were predominantly increased in hyperadrenocorticism and decreased in hypoadrenocorticism, while amino acid concentrations changed in various directions. Many observed serum metabolic abnormalities tended to normalize with medical treatment, but normalization was incomplete when compared to levels in apparently healthy dogs. Application of machine learning models based on the metabolomics data showed good classification, with misclassifications primarily observed in treated groups. Characterization of metabolic changes enhances our understanding of these endocrinopathies. Further assessment of the recognized incomplete reversal of metabolic alterations during medical treatment may improve disease management.Peer reviewe

Metabolomic Abnormalities in Serum from Untreated and Treated Dogs with Hyper- and Hypoadrenocorticism

The adrenal glands play a major role in metabolic processes, and both excess and insufficient serum cortisol concentrations can lead to serious metabolic consequences. Hyper- and hypoadrenocorticism represent a diagnostic and therapeutic challenge. Serum samples from dogs with untreated hyperadrenocorticism (n = 27), hyperadrenocorticism undergoing treatment (n = 28), as well as with untreated (n = 35) and treated hypoadrenocorticism (n = 23) were analyzed and compared to apparently healthy dogs (n = 40). A validated targeted proton nuclear magnetic resonance (1H NMR) platform was used to quantify 123 parameters. Principal component analysis separated the untreated endocrinopathies. The serum samples of dogs with untreated endocrinopathies showed various metabolic abnormalities with often contrasting results particularly in serum concentrations of fatty acids, and high- and low-density lipoproteins and their constituents, which were predominantly increased in hyperadrenocorticism and decreased in hypoadrenocorticism, while amino acid concentrations changed in various directions. Many observed serum metabolic abnormalities tended to normalize with medical treatment, but normalization was incomplete when compared to levels in apparently healthy dogs. Application of machine learning models based on the metabolomics data showed good classification, with misclassifications primarily observed in treated groups. Characterization of metabolic changes enhances our understanding of these endocrinopathies. Further assessment of the recognized incomplete reversal of metabolic alterations during medical treatment may improve disease management

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

AbstractTransfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been mixed, potentially due to the heterogeneous nature of CP. Here we perform deep profiling of SARS-CoV-2-specific antibody titer, Fc-receptor binding, and Fc-mediated functional assays in CP units, as well as in plasma from hospitalized COVID-19 patients before and after CP administration. The profiling results show that, although all recipients exhibit expanded SARS-CoV-2-specific humoral immune responses, CP units contain more functional antibodies than recipient plasma. Meanwhile, CP functional profiles influence the evolution of recipient humoral immunity in conjuncture with the recipient’s pre-existing SARS-CoV2-specific antibody titers: CP-derived SARS-CoV-2 nucleocapsid-specific antibody functions are associated with muted humoral immune evolution in patients with high titer anti-spike IgG. Our data thus provide insights into the unexpected impact of CP-derived functional anti-spike and anti-nucleocapsid antibodies on the evolution of SARS-CoV-2-specific response following severe infection.</jats:p