5 research outputs found
Simvastatin decreases hepatic ischaemia/reperfusion-induced liver and lung injury in rats
Liver failure is still a significant clinical problem after transplantation surgery,
tissue resections (the Pringle manoeuvre) and haemorrhagic shock. The restoration
of blood flow to an ischaemic region leads to tissue injury at a greater
rate than the original ischaemic insult, an event termed "ischaemia-reperfusion
injury" (I/R). Despite advances in surgical techniques, I/R still poses a problem
of clinical importance. In this research, we studied the effect of simvastatin
pretreatment on liver and lung injury induced by hepatic I/R.
Rats were subjected to 30 min of ischaemia followed by 24 h of reperfusion.
Simvastatin (10 mg/kg) was administered orally from three days before the
operation. After the reperfusion time, serum ALT, AST, LDH and TNF a levels
were studied and liver and lung tissues were stained with haematoxylin and
eosin and TUNEL to detect apoptotic cells.
Serum aminotransferase activity and LDH and TNFα levels were increased markedly
by hepatic I/R, and these were suppressed significantly by simvastatin. The
tissue injury index and the number of apoptotic cells via TUNEL staining in the
liver and lungs were higher in the I/R group than in the I/R + simvastatin group.
These results suggest that simvastatin ameliorates I/R-induced liver and lung tissue
damage by inhibiting the level of inflammation and the apoptotic pathways.
Simvastatin administration may therefore provide protection against the adverse
effects of I/R injury in liver transplantation
Expanded polytetrafluoroethylene as an auxetic material: effect of extension ratio on its structure and properties
Association of pre-transplant statin use with delayed graft function in kidney transplant recipients
Background: Administration of HMG-CoA reductase inhibitors (statins), prior to ischemia or prior to reperfusion has been shown to decrease ischemia-reperfusion renal injury in animal studies. It is unknown whether this protective effect is applicable to renal transplantation in humans. The aim of this study was to determine the relationship between prior statin use in renal transplant recipients and the subsequent risk of delayed graft function