Rational antimicrobial therapy for sepsis in cattle in face of the new legislation on critically important antimicrobials

Sepsis is a life-threatening condition in cattle, as in humans. Successful sepsis treatment requires a fast initiation of antimicrobial therapy with a broad-spectrum, bactericidal drug, administered intravenously. However, the new legislation limits the use of critically important fluoroquinolones and cephalosporins in food animal medicine, drugs which are considered highly effective for sepsis treatment and were previously frequently used for this indication. This article aims at providing an overview of the current knowledge of sepsis in cattle to aid practitioners in adapting their decision making process to treat sepsis. Sepsis incidence in cattle is likely seriously underestimated. This disease is almost unexplored in cattle, which makes it particularly difficult to design species specific guidelines. Sepsis diagnosis by blood culture reaches sufficient accuracy with the current laboratory technology. When adapting this procedure to a field environment, difficulties might arise, and the availability of adapted incubators in veterinary laboratories may be limited. However, these difficulties are likely to be overcome. Severe sepsis and septic shock are likely the only indications where the 'urgency' criterion of the new legislation would apply, but it is important to realize that alternative antimicrobial treatments with possibly similar efficacy are available

Electrocardiography in horses, part 1: how to make a good recording

Upon auscultation, cardiac dysrhythmias can be suspected, but electrocardiography is the ultimate diagnostic tool. Electrocardiogram (ECG) recording used to be reserved to specialized centers, but nowadays relatively cheap and small recorders are available to the practitioner in the field. ECGs can therefore be recorded ambulatory and during prolonged periods at rest or even during exercise. The know-how of a good quality recording is mandatory for a correct diagnosis. The basic equipment consists of electrodes, a recorder and a way to display the trace. Self-adhesive electrodes should be used, and positioned along the mean electrical axis of the heart. Small recording devices offer the advantage of allowing recordings during exercise. As the electrical impulse spreads through the heart, the ECG trace shows successively a P wave, a QRS complex and a T wave. T-a waves are not always clearly visible in horses. The positioning of the electrodes may differ for ambulatory, exercise or long-term resting recordings. However, as long as the electrodes are positioned along the mean electrical axis, their exact position is not of crucial importance

Risk factors for antimicrobial use in food-producing animals : disease prevention and socio-economic factors as the main drivers?

The European Union requests an urgent decrease in antimicrobial use (AMU) in food producing animals to reduce antimicrobial resistance in animals and humans and safeguard the efficacy of antimicrobials for future generations. The identification of risk factors (RFs) for AMU is essential to obtain a rapid reduction. The aim of this review was to summarize the current knowledge of RFs for AMU in veal calves, pigs and poultry. Thirty-three observational studies were included. Well-identified RFs for an increased AMU are frequent purchase of animals, herd size (large or small depending on the animal species), and a lack of selected biosecurity measures. Also in beef breed calves, more antimicrobials are used than in Holstein calves. AMU is influenced by the farmer, the veterinarian and by the integration. In general, socio-economic RFs are largely unexplored. The causal factors for AMU are multiple and complex, with possible confounding factors and unidentified interactions. Additional knowledge of socio-economic drivers appears particularly urgent to create tailor-made guidelines and awareness campaigns for each sector