The effect of attachment styles on attitude towards help seeking

The aim of the study is to determine whether there is a difference among university students’ attitudes towards help seeking in regard to their attachment styles. Participants of this study were composed of 572 university students (264 female, 308 male). The data was obtained by using the Attitudes toward Seeking Psychological Help – Shortened and Relationship Questionnaire. One way analysis of covariance (ANCOVA) was used to analyze the data. Dependent variable of the study was attitude towards help seeking, independent variable was attachment style and covariance was gender. The findings of the study indicated that students with secure attachment style was found to have more positive attitude towards psychological help seeking than preoccupied and fearful attachment styles

Gold(i)/Zn(ii) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles

The tandem hydroamination-annulation reaction of 4-pentyne-nitriles in the presence of amine nucleophiles and a cooperatively operating catalyst system, consisting of Ph3PAuCl and Zn(ClO4)2, provides an efficient route to 2-aminopyrroles. Two regioisomeric 2-aminopyrroles were formed in moderate to good yields. © 2010 The Royal Society of Chemistry.TÜBİTAK; TÜBA and MET

Effects of the ATP-dependent K (+)-channel effectors pinacidil and glibenclamide on liver tissue in an experimental model of epilepsy: A histopathological study

Aim: It is known that most of the antiepileptic drugs have negative effects on the liver. Pinacidil is a nonselective opener of KATP channels, including the plasma membrane and mitochondria.  Glibenclamide is an ATP -dependent K channel blocker ensuring the intake of calcium. Our aim in this experimental study was to examine the effects of pinacidil and glibenclamide on the liver tissue of rats with focal epilepsy. Method: Sixty male Sprague Dawley rats (2-4 months old, 200-250 gr) were used in the study. The rats were divided into 4 groups, 15 in each group. The groups were divided into control group, penicillin group, penicillin + pinacidil group and penicillin + glibenclamide group. The craniums of the rats in the control group were opened and normal saline was given; Penicillin (2 µl 500 IU) was intracortically administered to other groups and an experimental epilepsy model was created. At the end of the study, liver tissue of rats was taken and evaluated in terms of vacuolar degeneration, lymphocyte infiltration, vascular congestion, sinusoidal dilatation, necrosis, and Kupffer cell proliferation, radial alignment of hepatic cords, central vein and portal vein dilatation in hepatocytes. Results: Venous congestion, cytoplasmic vacuolization, Kupffer cell proliferation, portal vein dilatation and necrosis were distinct in the group to which pinacidil was administered, and distortion was present in the radial sequence (p<0.001).  In addition, inflammation, venous congestion and hepatocyte necrosis were found to be lower in the glibenclamide given group compared to the control group (p<0.001). Conclusion: It can be suggested that pinacidil treatment caused negative results in liver histopathological parameters, whereas glibenclamide was more protective by reducing inflammation, venous congestion and hepatocyte necrosis

Growth of Children with Type 1 Diabetes Mellitus

Objective: To retrospectively evaluate the effect of type 1 diabetes on growth

Fine−Needle Aspiration Biopsy in the Diagnosis and Follow−Up of Thyroid Nodules in Childhood

Objective: To assess the role of fine−needle aspiration biopsy (FNAB) in the management of pediatric thyroid nodules

Oligonucleotide Delivery Systems for Camptothecins

Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy

The effects of treadmill exercise on oxidative stress in Mongolian gerbils with penicillin-induced epilepsy

Aim: To evaluate the role of treadmill exercise on the oxidative stress in Mongolian gerbils with penicillin-induced epilepsy. Methods: This experimental study included 18 male Mongolian gerbils which were divided into three groups; sham-control group, penicillin group (500 units) and exercise + penicillin (500 units) group. Each animal group was composed of six Mongolian gerbils. The epileptiform activity was verified by electrocorticographic recordings.  Results: The latency of the penicillin+exercise group was longer than the penicillin group, but this difference was not statistically significant. Following the penicillin administration, spike wave frequencies of epileptiform activity in the 10, 30, and 35 minutes were significantly lower in the penicillin+exercise group, compared with the penicillin group. There were generally significant decreases in the spike wave amplitude medians in the penicillin+exercise groups compared with the penicillin group in all time periods between 0 and 5 minutes. The serum superoxide dismutase, catalase and glutathione peroxidase levels increased in the penicillin+exercise group compared with those in the penicillin group.  Conclusion: The results of present study indicate that regular exercise may contribute to the amelioration of epileptic activity by increasing the antioxidant effect. Keywords: Penicillin-induced epilepsy; treadmill exercise; oxidative stress; Mongolian gerbils.                  &nbsp

Investigation of mixed mode-I/II fracture problems - Part 2: evaluation and development of mixed mode-I/II fracture criteria

In this study, experimental and numerical results of compact tension shear (CTS) specimen and a new specimen type under in-plane mixed mode (Mode-I/II) loading conditions are compared with existing inplane mixed mode fracture criteria to investigate and understand the nature of fracture behavior properly. The material used in numerical and experimental analyses is Al 7075-T651 aluminum machined from rolled plates in the L-T rolling direction (crack plane is perpendicular to the rolling direction). In Part 1 of the study, results from numerical and experimental analyses are given. Having computed the mixed mode stress intensity factors from the numerical analyses, fracture loads are predicted and compared with different mixed mode-I/II fracture criteria. The experimental and numerical results show that many criteria are in good agreement with each other for predominately mode I to moderate mixed mode conditions. However, existing criteria increasingly differ from the experimental measurements for highly mode-II conditions. Using the computational and experimental results obtained, improved empirical mixed mode I/II fracture criteria for fracture condition and angle are also proposed

Water Soluble Derivatives of Camptothecin/Homocamptothecin

Camptothecin and homocamptothecin analogs and derivatives are provided incorporating alkylamine and polyalkylamine moieties