Changes in travel behavior during the transition from secondary to higher education : a case study from Ghent, Belgium

Over the past few decades, the number of students attending universities and university colleges in Belgium has increased considerably. In many Western countries, this trend is accompanied by a decline in car use among young adults. Therefore, it is important to have better insights into how travel behavior changes during the transition from secondary to higher education. This research fits into the larger framework of mobility biographies, where travel behavior is analyzed over a life course, taking into account certain life events. Hierarchical logistic regressions are used to analyze car use data for mandatory activities (going to school and grocery shopping) and leisure activities (fun shopping) of 404 first-year university and university college students in Ghent (Belgium). The results indicate that holding a driver’s license or owning a car facilitates car use irrespective of students’ residential location and lifestyle, and this is true for all activities. The built environment only seems to become an important factor explaining car use when students are attending university or university college. The influence of lifestyles appears to become somewhat more important for leisure activities, such as fun shopping. The emerging lifestyle of students appears to become more individual and more independent from the lifestyle of others, especially the parents. This is supported by the declining influence of social networks, notably the family

Draft genome sequence of Pseudomonas moraviensis R28-S

We report the draft genome sequence of Pseudomonas moraviensis R28-S, isolated from the municipal wastewater treatment plant of Moscow, ID. The strain carries a native mercury resistance plasmid, poorly maintains introduced IncP-1 antibiotic resistance plasmids, and has been useful for studying the evolution of plasmid host range and stability

Treatment of a malignant peripheral nerve sheath tumor by intravenous administration of combretastatin A4-phosphate in a dog

A fifteen-year-old, male, castrated American Staffordshire terrier was presented with a subcutaneous, ulcerated mass on the right carpal joint. Thoracic radiographs and abdominal ultrasound were both negative for metastatic disease. Punch biopsies revealed the histopathological diagnosis of a malignant peripheral nerve sheath tumor. Due to the extent of the primary mass, local excision was not possible, and amputation of the limb was not an option for the owner. The dog was treated with intravenous administration of combretastatin A4-phosphate, a vascular disrupting agent. A biopsy was taken before and after treatment and power-Doppler ultrasound and contrast-enhanced ultrasound were performed to assess pre- and posttreatment evaluation of the tumor vasculature. The treatment resulted in massive necrosis of the tumor

Growth differentiation factor 15 : a novel biomarker with high clinical potential

Initially considered as a macrophage inhibitor (macrophage inhibitory cytokine-1), growth differentiation factor 15 (GDF-15) has been identified as a pleiotropic protein that plays key roles in prenatal development, in inflammation, in the regulation of cellular responses to stress signals, and in tissue repair after acute injuries in adult life. Multiple studies have revealed that GDF-15, a distant member of the transforming growth factor beta (TGF-beta) family, acts as a critical hormone to regulate lipid and carbohydrate metabolism. Besides its role in the tumorigenesis and diagnosis of cancer, serum GDF-15 concentrations reflect a systemic response and are predictive of all-cause mortality. Based on the knowledge from animal studies of its involvement in multiple inflammatory processes, we will focus in this review on the current clinical data on GDF-15 as a biomarker for cardiovascular disease, kidney disease, liver disease, the metabolic syndrome, diabetes mellitus, and sepsis

Quantification of measurement and model effects in monopile foundation scour protection experiments

The present work introduces an analysis of the measurement and model effects that exist in monopile scour protection experiments with repeated small scale tests. The damage erosion is calculated using the three dimensional global damage number S3D and subarea damage number S3D,i. Results show that the standard deviation of the global damage number σ(S3D)=0.257 and is approximately 20% of the mean S3D, and the standard deviation of the subarea damage number σ(S3D,i)=0.42 which can be up to 33% of the mean S3D. The irreproducible maximum wave height, chaotic flow field and non-repeatable armour layer construction are regarded as the main reasons for the occurrence of strong model effects. The measurement effects are limited to σ(S3D)=0.039 and σ(S3D,i)=0.083, which are minor compared to the model effects

Comparison of the sensitivity of culture, PCR and quantitative real-time PCR for the detection of Pseudomonas aeruginosa in sputum of cystic fibrosis patients

Background: Pseudomonas aeruginosa is the major pathogen involved in the decline of lung function in cystic fibrosis (CF) patients. Early aggressive antibiotic therapy has been shown to be effective in preventing chronic colonization. Therefore, early detection is important and sensitive detection methods are warranted. In this study, we used a dilution series of P. aeruginosa positive sputa, diluted in a pool of P. aeruginosa negative sputa, all from CF patients-to mimick as closely as possible the sputa sent to routine laboratories-to compare the sensitivity of three culture techniques versus that of two conventional PCR formats and four real-time PCR formats, each targeting the P. aeruginosa oprL gene. In addition, we compared five DNA-extraction protocols. Results: In our hands, all three culture methods and the bioMerieux easyMAG Nuclisens protocol Generic 2.0.1, preceded by proteinase K pretreatment and followed by any of the 3 real-time PCR formats with probes were most sensitive and able to detect P. aeruginosa up to 50 cfu/ml, i.e. the theoretical minimum of one cell per PCR mixture, when taking into account the volumes used in this study of sample for DNA-extraction, of DNA-elution and of DNA-extract in the PCR mixture. Conclusion: In this study, no difference in sensitivity could be found for the detection of P. aeruginosa from sputum between microbiological culture and optimized DNA-extraction and real-time PCR. The results also indicate the importance of the optimization of the DNA-extraction protocol and the PCR format