A systematic review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations

<p>Abstract</p> <p>Background</p> <p>There is growing interest in the use of cognitive, behavioural, and organisational theories in implementation research. However, the extent of use of theory in implementation research is uncertain.</p> <p>Methods</p> <p>We conducted a systematic review of use of theory in 235 rigorous evaluations of guideline dissemination and implementation studies published between 1966 and 1998. Use of theory was classified according to type of use (explicitly theory based, some conceptual basis, and theoretical construct used) and stage of use (choice/design of intervention, process/mediators/moderators, and post hoc/explanation).</p> <p>Results</p> <p>Fifty-three of 235 studies (22.5%) were judged to have employed theories, including 14 studies that explicitly used theory. The majority of studies (n = 42) used only one theory; the maximum number of theories employed by any study was three. Twenty-five different theories were used. A small number of theories accounted for the majority of theory use including PRECEDE (Predisposing, Reinforcing, and Enabling Constructs in Educational Diagnosis and Evaluation), diffusion of innovations, information overload and social marketing (academic detailing).</p> <p>Conclusions</p> <p>There was poor justification of choice of intervention and use of theory in implementation research in the identified studies until at least 1998. Future research should explicitly identify the justification for the interventions. Greater use of explicit theory to understand barriers, design interventions, and explore mediating pathways and moderators is needed to advance the science of implementation research.</p

X-ray diffraction study of feline leukemia virus fusion peptide and lipid polymorphism

AbstractThe structural effects of the fusion peptide of feline leukemia virus (FeLV) on the lipid polymorphism of N-methylated dioleoylphosphatidylethanolamine were studied using a temperature ramp with sequential X-ray diffraction. This peptide, the hydrophobic amino-terminus of p15E, has been proven to be fusogenic and to promote the formation of highly curved, intermediate structures on the lamellar liquid-crystal to inverse hexagonal phase transition pathway. The FeLV peptide produces marked effects on the thermotropic mesomorphic behaviour of MeDOPE, a phospholipid with an intermediate spontaneous radius of curvature. The peptide is shown to reduce the lamellar repeat distance of the membrane prior to the onset of an inverted cubic phase. This suggests that membrane thinning may play a role in peptide-induced membrane fusion and strengthens the link between the fusion pathway and inverted cubic phase formation. The results of this study are interpreted in relation to models of the membrane fusion mechanism

Distribution of modern benthic foraminiferal assemblages across the Northeast Greenland continental shelf

Analysis of benthic foraminifera in surface samples from 23 sites on the Northeast Greenland continental shelf reveal key assemblage differences between sites. Cluster analysis creates two clear geographical faunal assemblage zones: the 1) inner shelf, and 2) mid and outer shelf sites. These assemblages differ significantly, with the inner shelf sites being characterised by a high percentage and concentration of calcareous species, whilst the mid and outer shelf sites are dominated by agglutinated taxa. At almost all sites, the calcareous assemblages are dominated by Cassidulina neoteretis and Cassidulina reniforme, suggesting that they thrive across the shelf. Stetsonia horvathi, Oridorsalis tener, as well as Glomulina oculus and other miliolid species are found to be key calcareous species at many sites in the inner shelf zone, but they are rare-to-absent on the mid and outer shelf. Canonical correspondence analysis shows that September sea-ice cover and bottom water oxygen content are positively correlated with benthic foraminiferal assemblages at inner shelf sites, whereas organic carbon content is correlated with those in the mid and outer shelf. The formation of seasonal sea-ice and the Northeast Water polynya rejects brine into surrounding waters and transports CO2 to the seafloor, creating a highly corrosive environment for calcium carbonate. These environments are also highly productive, as indicated by the high organic carbon content and low bottom water oxygen content. The oxidation of this organic material creates CO2. We propose that these processes are key drivers in the dissolution of calcareous tests. In contrast, extensive sea-ice, high bottom water oxygen content and low primary productivity in the glacier-proximal region facilitates carbonate preservation

Star Formation in Quasar Disk

Using a version of the ZEUS code, we carry out two-dimensional simulations of self-gravitating shearing sheets, with application to QSO accretion disks at a few thousand Schwarzschild radii, corresponding to a few hundredths of a parsec for a 10^8 solar-mass black hole. Radiation pressure and optically thick radiative cooling are implemented via vertical averages. We determine dimensionless versions of the maximum surface density, accretion rate, and effective viscosity that can be sustained by density-wave turbulence without fragmentation. Where fragments do form, we study the final masses that result. The maximum Shakura-Sunyaev viscosity parameter is approximately 0.4. Fragmentation occurs when the cooling time is less than about twice the shearing time, as found by Gammie and others, but can also occur at very long cooling times in sheets that are strongly radiation-pressure dominated. For accretion at the Eddington rate onto a 10^8 solar-mass black hole, fragmentation occurs beyond four thousand Schwarzschild radii, r_s. Near this radius, initial fragment masses are several hundred suns, consistent with estimates from linear stability; final masses after merging increase with the size of the sheet, reaching several thousand suns in our largest simulations. With increasing black-hole mass at a fixed Eddington ratio, self-gravity prevails to smaller multiples of r_s, where radiation pressure is more important and the cooling time is longer compared to the dynamical time; nevertheless, fragmentation can occur and produces larger initial fragment masses. We also find energy conservation is likely to be a challenge for all eulerian codes in self-gravitating regimes where radiation pressure dominates.Comment: 34 pages, 8 figures. Submitted to Ap