Methods for the analysis of quality-of-life and survival data in health technology assessment

Methods for the analysis of quality-of-life and survival data in health technology assessmen

Bayesian methods in health technology assessment: a review

Bayesian methods in health technology assessment: a revie

Leatherbacks thermoregulate by controlling both heat loss and heat gain.

<p>A 3D image showing how activity (heat production) and thermal admittance (heat loss) affect the thermal gradient (<i>T_B-T_W</i>) held by juvenile leatherbacks. In cold water heat loss was minimized and activity was proportional to the thermal gradient held. In warm water activity was very low and thermal gradient was due to varying heat loss.</p

Methods in health service research: An introduction to bayesian methods in health technology and assessment

Methods in health service research: An introduction to bayesian methods in health technology and assessmen

Recorded and calculated values at each water temperature for the 16 kg leatherback.

<p>Recorded and calculated values at each water temperature for the 16 kg leatherback.</p

Flexible parametric models for relative survival, with application in coronary heart disease

Relative survival is frequently used in population-based studies as a method for estimating disease-related mortality without the need for information on cause of death. We propose an extension to relative survival of a flexible parametric model proposed by Royston and Parmar for censored survival data. The model provides smooth estimates of the relative survival and excess mortality rates by using restricted cubic splines on the log cumulative excess hazard scale. The approach has several advantages over some of the more standard relative survival models, which adopt a piecewise approach, the main being the ability to model time on a continuous scale, the survival and hazard functions are obtained analytically and it does not use split-time data

The leatherbacks were exposed to stepwise changes in water temperature.

<p>The complete water temperature profile for the experiment performed on the 37 kg leatherback.</p

Assessing the costs of healthcare technologies in clinical trials

Assessing the costs of healthcare technologies in clinical trial

A leatherback's rate of heat production and heat loss depend on water temperature.

<p>Recorded and calculated values at each water temperature for the 37 kg leatherback.</p

Evaluating patient-based outcome measures for use in clinical trials

Evaluating patient-based outcome measures for use in clinical trial