Erotisierte Vaterliebe?: Analyse der BOLD-Antwort auf Kindchenschema-Reize bei teleiophilen und pädophilen Männern

Previous research found increased brain responses of men with sexual interest in children (i.e. pedophiles) not only to pictures of naked children but also to pictures of child faces. This opens the possibly that pedophilia is linked (in addition to or instead of an aberrant sexual system) to an over-active nurturing system. To test this hypothesis we exposed pedophiles and healthy controls to pictures of infant and adult animals during functional magnetic resonance imaging of the brain. By using pictures of infant animals (instead of human infants) we aimed to elicit nurturing processing without triggering sexual processing. We hypothesized that elevated brain responses to nurturing stimuli will be found – in addition to other brain areas – in the anterior insula of pedophiles because this area was repeatedly found to be activated when adults see pictures of babies. Behavioral ratings confirmed that pictures of infant or adult animals were not perceived as sexually arousing neither by the pedophilic participants nor by the healthy controls. Statistical analysis was applied to the whole brain as well as to the anterior insula as region of interest. Only in pedophiles did infants relative to adult animals increase brain activity in the anterior insula, supplementary motor cortex, and dorsolateral prefrontal areas. Within-group analysis revealed an increased brain response to infant animals in the left anterior insular cortex of the pedophilic participants. Currently, pedophilia is considered the consequence of disturbed sexual or executive brain processing, but details are far from known. The present findings raise the question whether there is also an over-responsive nurturing system in pedophilia

Challenges to estimating vaccine impact using hospitalization data.

Because the real-world impact of new vaccines cannot be known before they are implemented in national programs, post-implementation studies at the population level are critical. Studies based on analysis of hospitalization rates of vaccine-preventable outcomes are typically used for this purpose. However, estimates of vaccine impact based on hospitalization data are particularly prone to confounding, as hospitalization rates are tightly linked to changes in the quality, access and use of the healthcare system, which often occur simultaneously with introduction of new vaccines. Here we illustrate how changes in healthcare delivery coincident with vaccine introduction can influence estimates of vaccine impact, using as an example reductions in infant pneumonia hospitalizations after introduction of the 10-valent pneumococcal conjugate vaccine (PCV10) in Brazil. To this end, we explore the effect of changes in several metrics of quality and access to public healthcare on trends in hospitalization rates before (2008-09) and after (2011-12) PCV10 introduction in 2010. Changes in infant pneumonia hospitalization rates following vaccine introduction were significantly associated with concomitant changes in hospital capacity and the fraction of the population using public hospitals. Importantly, reduction of pneumonia hospitalization rates after PCV10 were also associated with the expansion of outpatient services in several Brazilian states, falling more sharply where primary care coverage and the number of health units offering basic and emergency care increased more. We show that adjustments for unrelated (non-vaccine) trends commonly employed by impact studies, such as use of single control outcomes, are not always sufficient for accurate impact assessment. We discuss several ways to identify and overcome such biases, including sensitivity analyses using different denominators to calculate hospitalizations rates and methods that track changes in the outpatient setting. Employing these practices can improve the accuracy of vaccine impact estimates, particularly in evolving healthcare settings typical of low- and middle-income countries

Effects of Cutting Planes on Filter Performance of FDM 3D-Printed X-Band Waveguide Filters

In this paper, the impact of E-plane and H-plane cuts on filter performance of 3D-printed waveguide filters manufactured with fused deposition modeling (FDM) is examined. The employed manufacturing procedure consists of FDM 3D-printing and the subsequent electroplating process. A number of samples in both configurations are fabricated and surveyed. The measurement results are quantified and a comparison is conducted. Finally, the differing filter behaviors are discussed

Technical Report on Visual Quality Assessment for Frame Interpolation

Current benchmarks for optical flow algorithms evaluate the estimation quality by comparing their predicted flow field with the ground truth, and additionally may compare interpolated frames, based on these predictions, with the correct frames from the actual image sequences. For the latter comparisons, objective measures such as mean square errors are applied. However, for applications like image interpolation, the expected user's quality of experience cannot be fully deduced from such simple quality measures. Therefore, we conducted a subjective quality assessment study by crowdsourcing for the interpolated images provided in one of the optical flow benchmarks, the Middlebury benchmark. We used paired comparisons with forced choice and reconstructed absolute quality scale values according to Thurstone's model using the classical least squares method. The results give rise to a re-ranking of 141 participating algorithms w.r.t. visual quality of interpolated frames mostly based on optical flow estimation. Our re-ranking result shows the necessity of visual quality assessment as another evaluation metric for optical flow and frame interpolation benchmarks.Comment: 11 pages, 6 figure

Transkulturelle deutschsprachige Übersetzung des Fragebogens Reflux Symptom Score-12

Bei der Diagnostik des laryngopharyngealen Refluxes (LPR) spielen neben einer anamnestischen und klinischen bzw. apparativen Beurteilung auch Fragebögen zur detaillierten Erfassung der Symptomatik eine wesentliche Rolle. Neben dem Reflux Symptom Index (RSI), dem bekanntesten LPR-Symptomfragebogen, wurde kürzlich auch ein neuer Fragebogen, „Reflux Symptom Score“ (RSS), sowie eine kürzere Version, der Reflux Symptom Score 12 (RSS-12), veröffentlicht. Letzterer ist allerdings nur in englischer, französischer und portugiesischer Sprache verfügbar, ermöglicht jedoch eine wesentlich genauere Differenzierung der Symptomatik unter Einbeziehung von Symptomstärke, Häufigkeit des Auftretens von Beschwerden sowie der refluxbezogenen Beeinträchtigung der Lebensqualität. Das Ziel dieser Arbeit ist daher, eine entsprechende transkulturelle deutschsprachige Übersetzung des RSS-12 (aktuell nun als G‑RSS-12 bezeichnet) mit Verständlichkeitstestung vorzustellen, um den klinischen und wissenschaftlichen Einsatz dieses Fragebogens auch im deutschsprachigen Raum zu ermöglichen

Helimeric porphyrinoids: Stereostructure and chiral resolution of meso -tetraarylmorpholinochlorins

The synthesis and chiral resolution of free-base and Ni(II) complexes of a number of derivatives of meso-tetraphenylmorpholinochlorins, with and without direct β-carbon-to-o-phenyl linkages to the flanking phenyl groups, is described. The morpholinochlorins, a class of stable chlorin analogues, were synthesized in two to three steps from meso-tetraphenylporphyrin. The conformations and the relative stereostructures of a variety of free-base and Ni(II) complexes of these morpholinochlorins were elucidated by X-ray diffractometry. Steric and stereoelectronic arguments explain the relative stereoarray of the morpholino-substituents, which differ in the free-base and Ni(II) complexes, and in the monoalkoxy, β-carbon-to-o-phenyl linked morpholinochlorins, and the dialkoxy derivatives. The Ni(II) complexes were all found to be severely ruffled whereas the free-base chromophores are more planar. As a result of the helimeric distortion of their porphyrinoid chromophores, the ruffled macrocycles possess a stable inherent element of chirality. Most significantly, resolution of the racemic mixtures was achieved, both by classical methods via diastereomers and by HPLC on a chiral phase. Full CD spectra were recorded and modeled using quantum-chemical computational methods, permitting, for the first time, an assignment of the absolute configurations of the chromophores. The report expands the range of known pyrrole-modified porphyrins. Beyond this, it introduces large chiral porphyrinoid π-systems that exist in the form of two enantiomeric, stereochemically stable helimers that can be resolved. This forms the basis for possible future applications, for example, in molecular-recognition systems or in materials with chiroptic properties. © 2011 American Chemical Society

Functionality of Two Origins of Replication in Vibrio cholerae Strains With a Single Chromosome

Chromosomal inheritance in bacteria usually entails bidirectional replication of a single chromosome from a single origin into two copies and subsequent partitioning of one copy each into daughter cells upon cell division. However, the human pathogen Vibrio cholerae and other Vibrionaceae harbor two chromosomes, a large Chr1 and a small Chr2. Chr1 and Chr2 have different origins, an oriC-type origin and a P1 plasmid-type origin, respectively, driving the replication of respective chromosomes. Recently, we described naturally occurring exceptions to the two-chromosome rule of Vibrionaceae: i.e., Chr1 and Chr2 fused single chromosome V. cholerae strains, NSCV1 and NSCV2, in which both origins of replication are present. Using NSCV1 and NSCV2, here we tested whether two types of origins of replication can function simultaneously on the same chromosome or one or the other origin is silenced. We found that in NSCV1, both origins are active whereas in NSCV2 ori2 is silenced despite the fact that it is functional in an isolated context. The ori2 activity appears to be primarily determined by the copy number of the triggering site, crtS, which in turn is determined by its location with respect to ori1 and ori2 on the fused chromosome