1,804 research outputs found
Chromosome location and characterization of genes for grain protein content in Triticum dicoccoides
Dissertação de Mestrado em História, apresentada à Faculdade de Letras da Universidade de Coimbra.No início do século XX, com a instalação da República portuguesa, surgiu a oportunidade de se construir um lar judaico num território português de além-mar. Angola foi uma forte possibilidade.
Vários fatores contribuíram para que tal oportunidade fosse possível. Os constantes massacres feitos ao povo judaico em variadíssimos países europeus, nomeadamente nos países de leste, e as dificuldades encontradas por Theodor Herzl, fundador do movimento sionista, para a edificação do desejado Estado judaico na Palestina, levou a que alguns líderes judaicos começassem a estudar outras hipóteses para o estabelecimento da comunidade judaica para além da Palestina. Era urgente encontrar uma solução para que o sofrimento dos judeus terminasse.
Por outro lado, é preciso não esquecer que Portugal se debatia com uma grande questão, a necessidade de ocupar efetivamente as suas colónias, a fim de contrariar as pretensões alemãs e inglesas. A hipótese de criar uma colónia judaica em Angola, como forma de enfrentar as aspirações alheias, e a necessidade de valorizar aquele território, faziam da colonização judaica uma boa solução para Portugal. Tendo em conta as dificuldades de um povoamento de Angola com elementos naturais da metrópole, devido à fraca capacidade financeira do Estado português e a razões sociais e mentais, a colonização judaica aparecia como uma alternativa viável.
No entanto, este projeto não se concretizaria. Serão identificados os fatores internos e externos que levaram a que este projeto não fosse posto em prática e tratar-se-á da posterior criação do Estado de Israel na Palestina, depois da Segunda Guerra Mundial.In the early XXth century, with the establishment of Portuguese Republic, arises
an opportunity of setting a jewish home in a portuguese land overseas. Angola was a
strong possibility.
Several factors contributed for the possibility of such opportunity. The constant
massacres the Jewish people suffered in numerous different European countries, mainly
in Eastern countries, and the difficulties encountered by Theodor Herlz, founder of the
Zionist movement, in order to build the desired Jewish State in Palestine, drove some of
jewish leaders to study other options to establish the home of Jewish people beyond
Palestine. It was urgent to find a solution for the suffering of the Jews to end.
On the other hand, it’s important not to forget that Portugal was struggling with
a big question, the necessity of effectively settling its colonies, in order to fight back the
German and English pretensions. The possibility of creating a jewish colony in Angola
as a way to prevent third-parties aspirations and the need of increase the value of
Angola land turned the jewish settlement into a good solution to Portugal. As the
colonization of Angola with natives from the metropolis appeared hard to reach, due to
a poor financial capacity of the portuguese State as well as social and mental factors, the
Jewish colonization appeared as a viable alternative.
However, this project wasn’t meant to achieve the goal. We’ll describe the
internal and external factors that caused the failure of this project and we’ll talk about
the creation, later on, of the Jewish State in Palestine, after Second World Wa
Chromosome location and characterization of genes for grain protein content in Triticum dicoccoides
Bayesian Best-Arm Identification for Selecting Influenza Mitigation Strategies
Pandemic influenza has the epidemic potential to kill millions of people.
While various preventive measures exist (i.a., vaccination and school
closures), deciding on strategies that lead to their most effective and
efficient use remains challenging. To this end, individual-based
epidemiological models are essential to assist decision makers in determining
the best strategy to curb epidemic spread. However, individual-based models are
computationally intensive and it is therefore pivotal to identify the optimal
strategy using a minimal amount of model evaluations. Additionally, as
epidemiological modeling experiments need to be planned, a computational budget
needs to be specified a priori. Consequently, we present a new sampling
technique to optimize the evaluation of preventive strategies using fixed
budget best-arm identification algorithms. We use epidemiological modeling
theory to derive knowledge about the reward distribution which we exploit using
Bayesian best-arm identification algorithms (i.e., Top-two Thompson sampling
and BayesGap). We evaluate these algorithms in a realistic experimental setting
and demonstrate that it is possible to identify the optimal strategy using only
a limited number of model evaluations, i.e., 2-to-3 times faster compared to
the uniform sampling method, the predominant technique used for epidemiological
decision making in the literature. Finally, we contribute and evaluate a
statistic for Top-two Thompson sampling to inform the decision makers about the
confidence of an arm recommendation
Effects of pathogen dependency in a multi-pathogen infectious disease system including population level heterogeneity – a simulation study
Prognosis of Sentinel Node Staged Patients with Primary Cutaneous Melanoma
Background: This study investigated survival probabilities and prognostic factors in sentinel lymph node biopsy (SLNB) staged patients with cutaneous melanoma (CM) with the aim of defining subgroups of patients who are at higher risk for recurrences and who should be considered for adjuvant clinical trials.\ud
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Methods: Patients with primary CM who underwent SLNB in the Department of Dermatology, University of Tuebingen, Germany, between 1996 and 2009 were included into this study. Survival probabilities and prognostic factors were evaluated by Kaplan-Meier and multivariate Cox proportional hazard models.\ud
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Results: 1909 SLNB staged patients were evaluated. Median follow-up time was 44 months. Median tumor thickness was 1.8 mm, ulceration was present in 31.8% of cases. The 5-year Overall Survival (OS) was 90.3% in SLNB negative patients (IB 96.2%, IIA 87.0%, IIB 78.1%, IIC 72.6%). Patients with micrometastases (stage IIIA/B) had a 5-year OS rate of 70.9% which was clearly less favorable than for stages I–II. Multivariate analysis revealed tumor thickness, ulceration, body site, histopathologic subtype and SLNB status as independent significant prognostic factors.\ud
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Conclusion: Survival rates of patients with primary CM in stages I–II were shown to be much more favorable than previously reported from non sentinel node staged collectives. For future clinical trials, sample size calculations should be adapted using survival probabilities based on sentinel node staging
Estimating Animal Abundance in Ground Beef Batches Assayed with Molecular Markers
Estimating animal abundance in industrial scale batches of ground meat is important for mapping meat products through the manufacturing process and for effectively tracing the finished product during a food safety recall. The processing of ground beef involves a potentially large number of animals from diverse sources in a single product batch, which produces a high heterogeneity in capture probability. In order to estimate animal abundance through DNA profiling of ground beef constituents, two parameter-based statistical models were developed for incidence data. Simulations were applied to evaluate the maximum likelihood estimate (MLE) of a joint likelihood function from multiple surveys, showing superiority in the presence of high capture heterogeneity with small sample sizes, or comparable estimation in the presence of low capture heterogeneity with a large sample size when compared to other existing models. Our model employs the full information on the pattern of the capture-recapture frequencies from multiple samples. We applied the proposed models to estimate animal abundance in six manufacturing beef batches, genotyped using 30 single nucleotide polymorphism (SNP) markers, from a large scale beef grinding facility. Results show that between 411∼1367 animals were present in six manufacturing beef batches. These estimates are informative as a reference for improving recall processes and tracing finished meat products back to source
A Unique Radiation Scheme for the Treatment of High-Grade Non-Metastatic Soft Tissue Sarcoma: The Detroit Medical Center Experience
Purpose:This is the initial report on the utilization of combined photon irradiation followed by a neutron boost irradiation
for the initial management of patients with high-grade non-metastatic soft tissue sarcoma (STS). We present data on local
control, complications, disease-free survival and overall survival in patients at high risk for local relapse
Autoimmune and autoinflammatory mechanisms in uveitis
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult; clinically, inflammation following such an insult is termed uveitis. The intra-ocular inflammation in uveitis may be clinically obvious as a result of infection (e.g. toxoplasma, herpes), but in the main infection, if any, remains covert. We now recognise that healthy tissues including the retina have regulatory mechanisms imparted by control of myeloid cells through receptors (e.g. CD200R) and soluble inhibitory factors (e.g. alpha-MSH), regulation of the blood retinal barrier, and active immune surveillance. Once homoeostasis has been disrupted and inflammation ensues, the mechanisms to regulate inflammation, including T cell apoptosis, generation of Treg cells, and myeloid cell suppression in situ, are less successful. Why inflammation becomes persistent remains unknown, but extrapolating from animal models, possibilities include differential trafficking of T cells from the retina, residency of CD8(+) T cells, and alterations of myeloid cell phenotype and function. Translating lessons learned from animal models to humans has been helped by system biology approaches and informatics, which suggest that diseased animals and people share similar changes in T cell phenotypes and monocyte function to date. Together the data infer a possible cryptic infectious drive in uveitis that unlocks and drives persistent autoimmune responses, or promotes further innate immune responses. Thus there may be many mechanisms in common with those observed in autoinflammatory disorders
The Pioneer Anomaly
Radio-metric Doppler tracking data received from the Pioneer 10 and 11
spacecraft from heliocentric distances of 20-70 AU has consistently indicated
the presence of a small, anomalous, blue-shifted frequency drift uniformly
changing with a rate of ~6 x 10^{-9} Hz/s. Ultimately, the drift was
interpreted as a constant sunward deceleration of each particular spacecraft at
the level of a_P = (8.74 +/- 1.33) x 10^{-10} m/s^2. This apparent violation of
the Newton's gravitational inverse-square law has become known as the Pioneer
anomaly; the nature of this anomaly remains unexplained. In this review, we
summarize the current knowledge of the physical properties of the anomaly and
the conditions that led to its detection and characterization. We review
various mechanisms proposed to explain the anomaly and discuss the current
state of efforts to determine its nature. A comprehensive new investigation of
the anomalous behavior of the two Pioneers has begun recently. The new efforts
rely on the much-extended set of radio-metric Doppler data for both spacecraft
in conjunction with the newly available complete record of their telemetry
files and a large archive of original project documentation. As the new study
is yet to report its findings, this review provides the necessary background
for the new results to appear in the near future. In particular, we provide a
significant amount of information on the design, operations and behavior of the
two Pioneers during their entire missions, including descriptions of various
data formats and techniques used for their navigation and radio-science data
analysis. As most of this information was recovered relatively recently, it was
not used in the previous studies of the Pioneer anomaly, but it is critical for
the new investigation.Comment: 165 pages, 40 figures, 16 tables; accepted for publication in Living
Reviews in Relativit
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