PLPMDB: Pyridoxal-5'-phosphate dependent enzymes mutants database

Abstract Summary: The searchable mutant database PLPMDB has been developed to provide rapid and simple access to relevant mutant information on pyridoxal-5′-phosphate dependent enzymes. All data have been extracted from publications and publicly available databases, then organized in a relational database to enable searching via a web-based search form. The current version of PLPMDB contains 688 mutants described in 220 research papers. The database is a useful tool for planning mutant experiments and for interpretation of information from such experiments. Availability: PLPMDB is freely accessible from http://www.studiofmp.com/plpmdb/index.ht

Raffaella Bombi e Fabiana Fusco (a cura di)

Quando, poco prima dell'estate, mi fu rivolto l'invito a presentare un volume di saggi in onore di Vincenzo Orioles, in occasione del suo sessantesimo compleanno, non ho avuto alcuna esitazione ad accogliere la proposta, e con grande piacere, misto a una nota malinconica, di cui pure dirò. La soddisfazione è certo suggerita da motivi scientifici, perché è sempre un grande onore poter festeggiare uno studioso largamente noto nel panorama della linguistica in Italia e all'estero, distintosi per una notevole varietà di interessi, ma nasce anche da ragioni personali, in quanto condivido con l'amico Orioles un lungo sodalizio, nato nei tempi ormai lontani - più di due decenni- del concorso che ci vide accomunati in un esito felice (e in ripetute visite a Viale Trastevere, aggiungerei, per far fronte ai continui intoppi burocratici che l'iter del decreto incontrava). Il rammarico, anch'esso di natura personale, deriva dal fatto che quando si è invitati a presentare un volume miscellaneo significa che sono irrimediabilmente trascorsi gli anni della ricerca spensierata - si fa per dire, ovviamente -, e che sono arrivati tempi di più gravose responsabilità. Dato che si tratta, però, di un evento pressoché fisiologico, temo proprio che ci si debba rassegnare di buon animo

Un millennio di storia linguistica albanese: l’influsso lessicale della lingua italiana

L'ampio saggio delinea analiticamente l'influsso lessicale dell'italiano sull'albanese, sia in una scansione cronologica, sia secondo un ordinamento per campi lessicali, con particolare attenzione alle modalità di integrazione fonologica, morfologica e semantica nella lingua albanese.The broad essay outlines in detail the Italian lexical influence on the Albanian language, both in a chronological order, and according to lexical fields, with a focus on the way how a phonological, morphological and semantic integration took place in Albanian

Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

Binding of herpes simplex virus (HSV) glycoprotein D (gD) to a cell surface receptor is required to trigger membrane fusion during entry into host cells. Nectin-1 is a cell adhesion molecule and the main HSV receptor in neurons and epithelial cells. We report the structure of gD bound to nectin-1 determined by x-ray crystallography to 4.0 Å resolution. The structure reveals that the nectin-1 binding site on gD differs from the binding site of the HVEM receptor. A surface on the first Ig-domain of nectin-1, which mediates homophilic interactions of Ig-like cell adhesion molecules, buries an area composed by residues from both the gD N- and C-terminal extensions. Phenylalanine 129, at the tip of the loop connecting β-strands F and G of nectin-1, protrudes into a groove on gD, which is otherwise occupied by C-terminal residues in the unliganded gD and by N-terminal residues in the gD/HVEM complex. Notably, mutation of Phe129 to alanine prevents nectin-1 binding to gD and HSV entry. Together these data are consistent with previous studies showing that gD disrupts the normal nectin-1 homophilic interactions. Furthermore, the structure of the complex supports a model in which gD-receptor binding triggers HSV entry through receptor-mediated displacement of the gD C-terminal region

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Marco Forni, Dizionario italiano-ladino gardenese. Dizioner ladin de gherdëina-talian (recensione)

In un articolo-recensione sono indicati i contributi e gli spunti di riflessione offerti dal fondamentale dizionario curato da Marco ForniA review-article shows the important contribution - as well as an incredible cue for reflection - that Marco Forni offers with his Dictionar

Gardenese zapadascia "piccolo atout"

Il saggio rintraccia l'origine di un vocabolo gardenese del giuoco di carte.The study traces back the origin of a Gard. word pertaining to card-games

Gli Aśvin sul far dell'alba (RV, X, 40, 2b).

Nel saggio si analizza una strofa di un inno del X libro del Rigveda e, sulla base di considerazioni linguistiche, filologiche ed ermeneutiche, si propone una diversa interpretazione di una forma di perfetto che vi compare (da riportare al verbo che indica il "portar luce" e non alla radice omofona "abitare").In the paper we analyze a stanza of a hymn of the tenth book of the Rigveda and, based on linguistic considerations, philological and hermeneutic, we propose a different interpretation of a form of perfect that there appears (to be reported to the verb meaning "" Take light "" and not the root homophonic "" live "")

Recensione a: E. Crespo y J. L. García Ramón, Berthold Delbrück y la sintaxis indoeuropea hoy, Actas del Coloquio de la Indogermanische Gesellschaft (Madrid, 21-24 de sept. de 1994), Madrid-Wiesbaden 1997

La recensione passa in rassegna i contributi pubblicati negli atti del convegno della Indogermanische Gesellschaft sullo stato attuale degli studi sulla sintassi indoeuropea; vengono proposte osservazioni critiche e integrazioni ad alcuni dei contributi pubblicati.The review provides an overview of the contributions published in the proceedings of the conference of the Indogermanische Gesellschaft on the current state of studies in the field of the Indo-European syntax. Both critical remarks and brief supplements are suggested as far as concerns some of the contributions in the volume

Declino di una categoria flessionale: l'intensivo in greco antico

Nel saggio si individuano due serie di forme flessionali del greco antico, presenti a raddoppiamento sillabico o lungo e perfetti cosiddetti intensivi, che a un'attenta analisi si rivelano essere relitti dell'antica categoria flessionale indoeuropea dell'intensivo, eliminata in greco - al pari delle altre categorie azionali - con conguagliamenti analogici a presente e perfetto.In this essay, we identify two sets of inflectional forms of Ancient Greek – present stems with either syllabic or long doubling and the so-called "intensive perfect stems" – that a careful analysis discloses as relics of the ancient Indo-European inflectional category of intensive. This category was rubbed out in Greek – as well as the other actional categories – through analogical adjustments to either present or perfect stems