A 4-D dataset for validation of crystal growth in a complex three-phase material, ice cream

Four dimensional (4D, or 3D plus time) X-ray tomographic imaging of phase changes in materials is quickly becoming an accepted tool for quantifying the development of microstructures to both inform and validate models. However, most of the systems studied have been relatively simple binary compositions with only two phases. In this study we present a quantitative dataset of the phase evolution in a complex three-phase material, ice cream. The microstructure of ice cream is an important parameter in terms of sensorial perception, and therefore quantification and modelling of the evolution of the microstructure with time and temperature is key to understanding its fabrication and storage. The microstructure consists of three phases, air cells, ice crystals, and unfrozen matrix. We perform in situ synchrotron X-ray imaging of ice cream samples using in-line phase contrast tomography, housed within a purpose built cold-stage (-40 to +20oC) with finely controlled variation in specimen temperature. The size and distribution of ice crystals and air cells during programmed temperature cycling are determined using 3D quantification. The microstructural evolution of three-phase materials has many other important applications ranging from biological to structural and functional material, hence this dataset can act as a validation case for numerical investigations on faceted and non-faceted crystal growth in a range of materials

Managing the complexity of doing it all : an exploratory study on students' experiences when trained stepwise in conducting consultations

Background: At most medical schools the components required to conduct a consultation, medical knowledge, communication, clinical reasoning and physical examination skills, are trained separately. Afterwards, all the knowledge and skills students acquired must be integrated into complete consultations, an art that lies at the heart of the medical profession. Inevitably, students experience conducting consultations as complex and challenging. Literature emphasizes the importance of three didactic course principles: moving from partial tasks to whole task learning, diminishing supervisors' support and gradually increasing students' responsibility. This study explores students' experiences of an integrated consultation course using these three didactic principles to support them in this difficult task. Methods: Six focus groups were conducted with 20 pre-clerkship and 19 clerkship students in total. Discussions were audiotaped, transcribed and analysed by Nvivo using the constant comparative strategy within a thematic analysis. Results: Conducting complete consultations motivated students in their learning process as future physician. Initially, students were very much focused on medical problem solving. Completing the whole task of a consultation obligated them to transfer their theoretical medical knowledge into applicable clinical knowledge on the spot. Furthermore, diminishing the support of a supervisor triggered students to reflect on their own actions but contrasted with their increased appreciation of critical feedback. Increasing students' responsibility stimulated their active learning but made some students feel overloaded. These students were anxious to miss patient information or not being able to take the right decisions or to answer patients' questions, which sometimes resulted in evasive coping techniques, such as talking faster to prevent the patient asking questions. Conclusion: The complex task of conducting complete consultations should be implemented early within medical curricula because students need time to organize their medical knowledge into applicable clinical knowledge. An integrated consultation course should comprise a step-by-step teaching strategy with a variety of supervisors' feedback modi, adapted to students' competence. Finally, students should be guided in formulating achievable standards to prevent them from feeling overloaded in practicing complete consultations with simulated or real patients

Radiative Seesaw Mechanism at Weak Scale

We investigate an alternative seesaw mechanism for neutrino mass generation. Neutrino mass is generated at loop level but the basic concept of usual seesaw mechanism is kept. One simple model is constructed to show how this mechanism is realized. The applications of this seesaw mechanism at weak scale to cosmology and neutrino physics are discussed.Comment: 12 Pages, latex, no figure

Patient-tailored risk assessment of obstructive coronary artery disease using Rubidium-82 PET-based myocardial flow quantification with visual interpretation

Introduction: Our aim was to estimate the probability of obstructive CAD (oCAD) for an individual patient as a function of the myocardial flow reserve (MFR) measured with Rubidium-82 (Rb-82) PET in patients with a visually normal or abnormal scan. Materials and Methods: We included 1519 consecutive patients without a prior history of CAD referred for rest-stress Rb-82 PET/CT. All images were visually assessed by two experts and classified as normal or abnormal. We estimated the probability of oCAD for visually normal scans and scans with small (5%–10%) or larger defects (&gt; 10%) as function of MFR. The primary endpoint was oCAD on invasive coronary angiography, when available. Results: 1259 scans were classified as normal, 136 with a small defect and 136 with a larger defect. For the normal scans, the probability of oCAD increased exponentially from 1% to 10% when segmental MFR decreased from 2.1 to 1.3. For scans with small defects, the probability increased from 13% to 40% and for larger defects from 45% to &gt; 70% when segmental MFR decreased from 2.1 to 0.7. Conclusion: Patients with &gt; 10% risk of oCAD can be distinguished from patients with &lt; 10% risk based on visual PET interpretation only. However, there is a strong dependence of MFR on patient’s individual risk of oCAD. Hence, combining both visual interpretation and MFR results in a better individual risk assessment which may impact treatment strategy.</p

Impact of age norms and stereotypes on managers' hiring decisions of retirees

Purpose -Our study investigates the role of managers in the re-employment of early retirees and asks what the effect is of managers’ age norms and stereotypes on managers’ employment decisions. Design/methodology/approach- A combination of a factorial study and a survey was conducted. First, information on the age norms and stereotypes was collected. Secondly, profiles of hypothetical retired job applicants were presented to the employers, who were asked to make a specific hiring decision. The information collected during both studies was combined in the analysis and multilevel models were estimated. Findings -The results indicate that higher age norms result in a higher propensity to hire an early retiree. Stereotypes, by contrast, do not influence managers’ decisions. Early retirees’ chances for re-employment are also related to their own circumstances (physical appearance and relevant experience) and organisational forces, as they are hired when organisations face labour force shortages. Research limitation / implications – with the use of vignettes study we deal with hypothetical hiring situation. Originality value- Although the effect of age norms and age stereotypes has been often suggested, not much empirical evidence was presented to support this notion. Our study estimates the effect of age norms and stereotypes on hiring decision. key words: bridge employment; early retirees; age norms; age stereotypes; multilevel models.

Tumor markers in breast cancer - European Group on Tumor Markers recommendations

Recommendations are presented for the routine clinical use of serum and tissue-based markers in the diagnosis and management of patients with breast cancer. Their low sensitivity and specificity preclude the use of serum markers such as the MUC-1 mucin glycoproteins ( CA 15.3, BR 27.29) and carcinoembryonic antigen in the diagnosis of early breast cancer. However, serial measurement of these markers can result in the early detection of recurrent disease as well as indicate the efficacy of therapy. Of the tissue-based markers, measurement of estrogen and progesterone receptors is mandatory in the selection of patients for treatment with hormone therapy, while HER-2 is essential in selecting patients with advanced breast cancer for treatment with Herceptin ( trastuzumab). Urokinase plasminogen activator and plasminogen activator inhibitor 1 are recently validated prognostic markers for lymph node-negative breast cancer patients and thus may be of value in selecting node-negative patients that do not require adjuvant chemotherapy. Copyright (C) 2005 S. Karger AG, Basel

The added value of immediate breast reconstruction to health-related quality of life of breast cancer patients

Background: Postmastectomy immediate breast reconstruction (IBR) may improve the quality of life (QoL) of breast cancer patients. Guidelines recommend to discuss the option IBR with all patients undergoing mastectomy. However, substantial hospital variation in IBR-rates was previously observed in the Netherlands, influenced by patient, tumour and hospital factors and clinicians’ believes. Information provision about IBR may have a positive effect on receiving IBR and therefore QoL. This study investigated patient-reported QoL of patients treated with mastectomy with and without IBR. Methods: An online survey, encompassing the validated BREAST-Q questionnaire, was distributed to a representative sample of 1218 breast cancer patients treated with mastectomy. BREAST-Q scores were compared between patients who had undergone mastectomy either with or without IBR. Results: A total of 445 patients were included for analyses: 281 patients with and 164 without IBR. Patients who had received IBR showed significantly higher BREAST-Q scores on “psychosocial well-being” (75 versus 67, p < 0.001), “sexual well-being” (62 versus 52, p < 0.001) and “physical well-being” (77 versus 74, p = 0.021) compared to patients without IBR. No statistically significant difference was found for “satisfaction with breasts” (64 versus 62, p = 0.21). Similar results were found after multivariate regression analyses, revealing IBR to be an independent factor for a better patient-reported QoL. Conclusions: Patients diagnosed with breast cancer with IBR following mastectomy report a better QoL on important psychosocial, sexual and physical well-being domains. This further supports the recommendation to discuss the option of IBR with all patients with an indication for mastectomy and to enable shared decision-making

Minimal Cooling of Neutron Stars: A New Paradigm

A new classification of neutron star cooling scenarios, involving either ``minimal'' cooling or ``enhanced'' cooling is proposed. The minimal cooling scenario replaces and extends the so-called standard cooling scenario to include neutrino emission from the Cooper pair breaking and formation process. This emission dominates that due to the modified Urca process for temperatures close to the critical temperature for superfluid pairing. Minimal cooling is distinguished from enhanced cooling by the absence of neutrino emission from any direct Urca process, due either to nucleons or to exotica. Within the minimal cooling scenario, theoretical cooling models can be considered to be a four parameter family involving the equation of state of dense matter, superfluid properties of dense matter, the composition of the neutron star envelope, and the mass of the neutron star. Consequences of minimal cooling are explored through extensive variations of these parameters. Results are compared with the inferred properties of thermally-emitting neutron stars in order to ascertain if enhanced cooling occurs in any of them. All stars for which thermal emissions have been clearly detected are at least marginally consistent with the lack of enhanced cooling. The two pulsars PSR 0833-45 (Vela) and PSR 1706-44 would require enhanced cooling in case their ages and/or temperatures are on the lower side of their estimated values whereas the four stars PSR 0656+14, PSR 1055-52, Geminga, and RX J0720.4-3125 may require some source of internal heating in case their age and/or luminosity are on the upper side of their estimated values. The new upper limits on the thermal luminosity of PSR J0205+6449 and RX J0007.0+7302 are indicative of the occurrence of some enhanced neutrino emission beyond the minimal scenario.Comment: Version to appear in ApJ Supplements. Minor modifications in text and discussion of updated data with new figure

A phenomenological equation of state for isospin asymmetric nuclear matter

A phenomenological momentum-independent (MID) model is constructed to describe the equation of state (EOS) for isospin asymmetric nuclear matter, especially the density dependence of the nuclear symmetry energy $E_{\text{\textrm{sym}}}(\rho)$. This model can reasonably describe the general properties of the EOS for symmetric nuclear matter and the symmetry energy predicted by both the sophisticated isospin and momentum dependent MDI model and the Skyrme-Hartree-Fock approach. We find that there exists a nicely linear correlation between $K_{\mathrm{sym}}$ and $L$ as well as between $J_{0}/K_{0}$ and $K_{0}$, where $L$ and $K_{\mathrm{sym}}$ represent, respectively, the slope and curvature parameters of the symmetry energy at the normal nuclear density $\rho_{0}$ while $K_{0}$ and $J_{0}$ are, respectively, the incompressibility and the third-order derivative parameter of symmetric nuclear matter at $\rho_{0}$. These correlations together with the empirical constraints on $K_{0}$, $L$ and $E_{\text{\textrm{sym}}}(\rho_{0})$ lead to an estimation of -477 MeV $\leq K_{\mathrm{sat,2}}\leq -241$ MeV for the second-order isospin asymmetry expansion coefficient for the incompressibility of asymmetric nuclear matter at the saturation point.Comment: 9 pages, 4 figures, contribution to Special Topic on Large-Scale Scientific Facilities (LSSF) in Science in China Series G: Physics, Mechanics & Astronom