Trilateral tumors in four different lines of transgenic mice expressing SV40 T-antigen

Journal ArticlePURPOSE. A line of transgenic mice containing the simian virus (SV) 40 T-antigen (T-ag) gene driven by the beta-luteinizing hormone (BLH) promoter developed bilateral retinoblastoma and primitive neuroectodermal tumors (PNET) of the midbrain. Midbrain tumors arose from the subependymal layer of the cerebral aqueduct. Bilateral ocular and brain tumors ("trilateral") were found in three other SV40 T-ag transgenic murine lines containing different promoters (murine interphotoreceptor retinoid-binding protein (IRBP), human IRBP, and alpha A-crystallin). To gain insight into the regulatory mechanisms involved in central nervous system tumorigenesis, the authors examined brain tumors from four lines of SV40 T-ag mice with different promoters. METHODS. Formalin-fixed brain tumors were examined from four lines of transgenic mice containing different promoters linked to the protein coding region of the enhancerless SV40 T-ag oncogene. Transgenes contained the following promoters: BLH, mouse 1.8-kb IRBP, human 1.3-kb IRBP, and alpha A-crystallin. RESULTS. Mice with a 1.8-kb IRBP promoter develop retinal photoreceptor and pineal tumors. Intracranial tumors arising from the subependymal layer of the third ventricle also were observed. Mice with a 1.3-kb IRBP promoter exhibit bilateral retinal PNET and PNET originating from the subependymal layer of the third ventricle. Mice with the alpha A-crystallin promoter exhibit bilateral lens tumors and PNET of the midbrain. CONCLUSIONS. Ocular tumors in these mice may be ascribed to the promoter-driven, tissue-specific expression of SV40 T-ag. The common finding of PNET arising from the subependymal layer of the diencephalon is unlikely to be promoter related. These findings indicate that a regulatory region specific to the subependymal layer of the cerebral aqueduct and third ventricle resides in the structural region of the SV40 T-ag gene

On the origin of discrepancies between observed and simulated memory of Arctic Sea ice

To investigate the inherent predictability of sea ice and its representation in climate models, we compare the seasonal-to-interannual memory of Arctic sea ice as given by lagged correlations of sea-ice area anomalies in large model ensembles (Max Planck Institute Grand Ensemble and Coupled Model Intercomparison Project phase 6) and multiple observational products. We find that state-of-the-art climate models significantly overestimate the memory of pan-Arctic sea-ice area from the summer months into the following year. This cannot be explained by internal variability. We further show that the observed summer memory can be disentangled regionally into a reemergence of positive correlations in the perennial ice zone and negative correlations in the seasonal ice zone; the latter giving rise to the discrepancy between observations and model simulations. These findings could explain some of the predictability gap between potential and operational forecast skill of Arctic sea-ice area identified in previous studies

Integrable Discretizations of Chiral Models

A construction of conservation laws for chiral models (generalized sigma-models on a two-dimensional space-time continuum using differential forms is extended in such a way that it also comprises corresponding discrete versions. This is achieved via a deformation of the ordinary differential calculus. In particular, the nonlinear Toda lattice results in this way from the linear (continuum) wave equation. The method is applied to several further examples. We also construct Lax pairs and B\"acklund transformations for the class of models considered in this work.Comment: 14 pages, Late

Nonlocal and local wind forcing dependence of the Atlantic meridional overturning circulation and its depth scale

We use wind sensitivity experiments to understand the wind forcing dependencies of the level of no motion and the e-folding pycnocline scale as well as their relationship to northward transport of the mid-depth Atlantic meridional overturning circulation (AMOC) south and north of the equator. In contrast to previous studies, we investigate the interplay of nonlocal and local wind effects on a decadal timescale. We use 30-year simulations with a high-resolution ocean general circulation model (OGCM) which is an eddy-resolving version of the Max Planck Institute Ocean Model (MPIOM). Our findings deviate from the common perspective that the AMOC is a nonlocal phenomenon only, because northward transport in the inter-hemispheric cell can only be understood by analyzing nonlocal Southern Ocean wind effects and local wind effects in the northern hemisphere downwelling region where Ekman pumping takes place. Southern Ocean wind forcing predominantly determines the magnitude of the pycnocline scale throughout the basin, whereas northern hemisphere winds additionally influence the level of no motion locally. In that respect, the level of no motion is a better proxy for northward transport and mid-depth velocity profiles despite the Ekman return flow which is found to be baroclinic. We compare our results inferred from the wind experiments and a 100-year global warming experiment in which the atmospheric CO2 concentration is quadrupled, using MPIOM coupled to an atmospheric model. We find that the evolution of the level of no motion in response to global warming represents changes in vertical velocity profiles or northward transport, whereas the changes of the pycnocline scale are opposite to the changes of the level of no motion over time. Using the level of no motion as depth scale, the analysis of the wind experiments and the warming experiment suggests a hemisphere-dependent scaling of the strength of AMOC. Furthermore, we put forward the idea that the ability of numerical models to capture the spatial and temporal variations of the level of no motion is crucial to reproduce the mid-depth cell in an appropriate wa

Flow Phase Diagram for the Helium Superfluids

The flow phase diagram for He II and $^3$He-B is established and discussed based on available experimental data and the theory of Volovik [JETP Letters {\bf{78}} (2003) 553]. The effective temperature - dependent but scale - independent Reynolds number $Re_{eff}=1/q=(1+\alpha')/\alpha$, where $\alpha$ and $\alpha'$ are the mutual friction parameters and the superfluid Reynolds number characterizing the circulation of the superfluid component in units of the circulation quantum are used as the dynamic parameters. In particular, the flow diagram allows identification of experimentally observed turbulent states I and II in counterflowing He II with the turbulent regimes suggested by Volovik.Comment: 2 figure

Oceanic Rossby waves drive inter-annual predictability of net primary production in the central tropical Pacific

In the Pacific Ocean, off-equatorial Rossby waves (RWs), initiated by atmosphere-ocean interaction, modulate the inter-annual variability of the thermocline. In this study, we explore the resulting potential gain in predictability of central tropical Pacific primary production, which in this region strongly depends on the supply of macronutrients from below the thermocline. We use a decadal prediction system based on the Max Planck Institute Earth system model to demonstrate that for the time period 1998-2014 properly initialized RWs explain an increase in predictability of net primary productivity (NPP) in the off-equatorial central tropical Pacific. We show that, for up to 5 years in advance, predictability of NPP derived from the decadal prediction system is significantly larger than that derived from persistence alone, or an uninitialized historical simulation. The predicted signal can be explained by the following mechanism: off-equatorial RWs are initiated in the eastern Pacific and travel towards the central tropical Pacific on a time scale of 2-6 years. On their arrival the RWs modify the depths of both thermocline and nutricline, which is fundamental to the availability of nutrients in the euphotic layer. Local upwelling transports nutrients from below the nutricline into the euphotic zone, effectively transferring the RW signal to the near-surface ocean. While we show that skillful prediction of central off-equatorial tropical Pacific NPP is possible, we open the door for establishing predictive systems for food web and ecosystem services in that region