Behaviour and stress in three breeds of laying hens kept in the same environment

The aim of the study was to determine whether birds of different breeds, with different preferences for environmental elements and kept in identical conditions, would exhibit different behaviour and stress levels. The research material consisted of 50 laying hens of the Green-legged partridge (Zk), Polbar (Pb), and Leghorn (Lg) breeds. The birds were provided with identical environmental conditions. They were kept on litter in separate boxes, with 25 individuals of one breed per box, in the same building. An open field test was used in determining the behaviour of the birds. Levels of cortisol in serum and corticosterone in feathers were evaluated, and haematological and biochemical analyses of blood were performed. Leghorns proved to be a highly excitable and active breed whose needs cannot be fully satisfied in the standard conditions of large farms. Based on a differential leukocyte count, their hyperactivity was associated with increased stress. The Green-legged partridge exhibited the lowest stress levels. Birds kept in the same environmental conditions were found to differ significantly in the level of stress, probably because of differences in their behavioural needs and the possibilities of satisfying them. To reduce stress levels and improve the welfare of hens, it is necessary to verify their preferences first. Stress indicators are elevated in highly excitable birds, and the conditions on large farms are not conducive to meeting their behavioural needs. Keywords: behavioural test, blood indices, corticosterone, laying hen

26 Ocena wyników pooperacyjnej radioterapii skojarzonej z 5-fluorouracylem u chorych na raka odbytnicy

Celem pracy była ocena wyników leczenia uzupełniającego z udziałem chemio- i radioterapii chorych po radykalnym zabiegu operacyjnym z powodu raka odbytnicy, ze szczególnym uwzględnieniem tolerancji leczenia. Materiał obejmuje 64 chorych leczonych w Klinice Onkologii i Radioterapii w Iatach1991–1995. Głównymi powikłaniami w czasie leczenia były biegunki (58%), nudności i wymioty (15%), objawy dyżuryczne (6%), leukopenia (33%) i niedokrwistość (5%). Do ostrych powikłań doszło ogółem 43 chorych (66%) w tym u 15 (23%) miały one charakter ciężki (stopień III i IV). Troje chorych nie ukończyło leczenia z powodu znacznego nasilenia objawów niepożądanych leczenia i pogorszenia stanu ogólnego.Późne powikłania, przede wszystkim w obrębie jelit i dróg moczowych, wystąpiły ogółem u 22 chorych (34%) w tym u 6 (9%)- w stopniu ciężkim. Spośród ocenionych 64 chorych dotychczas zmarło 19 (30%). Mediana czasu przeżycia w całej grupie wynosiła 37 miesięcy (11–60 miesięcy). Do wznowy miejscowej doszło u 15 chorych (23%) natomiast przerzuty odległe wystąpiły u 18 chorych (28%). Przedstawione wyniki, wskazujące na wysoki odsetek nawrotów oraz dużą liczbę powikłań popromiennych, skłoniły nas do zmiany techniki napromieniania. Efekty tych modyfikacji będzie można ocenić dopiero za kilka lat

A Theory of a Spot

We present a simple inflationary scenario that can produce arbitrarily large spherical underdense or overdense regions embedded in a standard Lambda cold dark matter paradigm, which we refer to as bubbles. We analyze the effect such bubbles would have on the Cosmic Microwave Background (CMB). For super-horizon sized bubble in the vicinity of the last scattering surface, a signal is imprinted onto CMB via a combination of Sach-Wolfe and an early integrated Sach-Wolfe (ISW) effects. Smaller, sub-horizon sized bubbles at lower redshifts (during matter domination and later) can imprint secondary anisotropies on the CMB via Rees-Sciama, late-time ISW and Ostriker-Vishniac effects. Our scenario, and arguably most similar inflationary models, produce bubbles which are over/underdense in potential: in density such bubbles are characterized by having a distinct wall with the interior staying at the cosmic mean density. We show that such models can potentially, with only moderate fine tuning, explain the \emph{cold spot}, a non-Gaussian feature identified in the Wilkinson Microwave Anisotropy Probe (WMAP) data by several authors. However, more detailed comparisons with current and future CMB data are necessary to confirm (or rule out) this scenario.Comment: 19 pages, 19 figures, added references and explanations, JCAP in pres

Media exposure, behavioural risk factors and HIV testing among women of reproductive age in Papua New Guinea: a cross-sectional study

Background: Reproductive health remains a major health concern in developing countries such as Papua New Guinea (PNG). The prevalence of human immunodeficiency virus (HIV) in PNG is the highest in the Southern Pacific region, with women having a higher risk of contracting the infection. Hence, there have been several policies aimed at mitigating the spread of the disease. One of these policies include the use of mass media as a health promotion tool to educate the population on the risk of the disease. Therefore, this study aimed at investigating the association of mass media to HIV testing among women. Methods: Data were obtained from the PNG Demographic and Health Survey (DHS) of 2019. A total of 15,005 reproductive-age women was included in this analysis. Results: The results showed that women with low (aOR = 1.63, 95% CI: 1.39, 1.90) and high (aOR = 1.53, 95% CI: 1.36, 1.72) media exposure were more likely to undertake HIV testing compared to those with no media exposure. Compared to no education, women with incomplete primary (aOR = 1.22, 95% CI: 1.06, 1.40), complete primary (aOR = 1.56, 95% CI: 1.30, 1.87), incomplete secondary (aOR = 2.18, 95% CI: 1.85, 2.58), complete secondary (aOR= 2.33, 95% CI: 1.77, 3.09) and higher (aOR = 3.38, 95% CI: 2.57, 4.46) education were more likely to undertake HIV testing. Compared to women with the poorest wealth index, women with richer indexes were more likely to undertake HIV testing. Women living in rural areas were less likely to undertake HIV testing (aOR = 0.72, 95% CI: 0.63, 0.82). However, marital status, knowledge of transmission and religion were not associated with HIV testing. Conclusion: In conclusion, this study provides strong evidence that mass media exposure increases the likelihood of HIV testing in women of reproductive age in PNG. Mass media campaigns would serve as a cost-effective health promotion tool against the spread of disease

Quantum geometry and gravitational entropy

Most quantum states have wavefunctions that are widely spread over the accessible Hilbert space and hence do not have a good description in terms of a single classical geometry. In order to understand when geometric descriptions are possible, we exploit the AdS/CFT correspondence in the half-BPS sector of asymptotically AdS_5 x S^5 universes. In this sector we devise a "coarse-grained metric operator" whose eigenstates are well described by a single spacetime topology and geometry. We show that such half-BPS universes have a non-vanishing entropy if and only if the metric is singular, and that the entropy arises from coarse-graining the geometry. Finally, we use our entropy formula to find the most entropic spacetimes with fixed asymptotic moments beyond the global charges.Comment: 29 pages, 2 figures; references adde

Adjuvant treatment of patients with rectal cancer

Adjuvant postoperative radiotherapy combined with chemotherapy is considered a standard management of rectal cancer patients with increased risk of local recurrence. In this study we evaluated the results of adjuvant chemo- and radiotherapy after radical surgery in 64 patients with rectal carcinoma with special reference to tolerance of treatment. All patients underwent radical surgery: anterior abdominal resection in 26, abdominoperineal resection in 19 and Hartman resection in one. Thirty three patients were postoperatively staged as Dukes B2 and 31 patients – as Dukes C. All patients received postoperative chemo-radiotherapy. Treatment included megavoltage irradiation with two parallel opposed fields to small pelvis at a dose of 45 Gy in 23–25 fractions and concomitant chemotherapy with 5-Fluorouracil during first three and last three days of irradiation.Main early complications from chemoradiation included diarrhea (58%), nausea and vomiting (15%), dysuria (6%), leukopenia (31%) and anaemia (4%). In total, acute side effects occured in 42 patients (66%) and in 16 of them (25%) were of grade 3 or 4. Three patients did not complete the treatment due to exacerbation of side effects and/or serious deterioration of performance status. Late complications, mainly from bowels and urinary bladder, occured in 19 patients (30%) and six of then (9%) were severe.Nineteen of the 64 evaluated patients have deceased ill now. Median survival was 29 months (4 to 50 months). Local recurrence was seen in 14 patients (22%) and distant metastases – in 18 (28%).Results of our study show that postoperative radiochemotherapy in rectal cancer patients is accompanied by a large number of acute and late complications. Literature data demonstrate that better tolerance of treatment may be achieved with the use of special surgical techniques preventing the replacement of small intestines to the pelvis after rectal amputation. Further improvement may be achieved with the use of multiple radiation fields, computerized treatment planning and customized blocking. Another option is an application of preoperative radiotherapy – the approach becoming recently more commonly used