Determinants of corporate governance disclosures by Australian listed companies subsequent to the introduction of ASX listing rule 4.10.3

This study has considered the incentives motivating listed mining and industrial companies to provide governance related disclosures in their annual reports. An examination is made of the impact of listing rule 4.10.3 that was applicable from 30 June 1996. Accordingly the years 1995, 1996 and 1997 are examined. A sample of 100 mining companies and 100 industrial companies was drawn primarily from the Connect 4 database of companies. Adopting political cost theory the study hypothesised that governance disclosures were positively related to the proportion of non-executive directors, gearing, ownership diffusion, Big 6 external auditor and firm size

Energy’s Role in the Extraversion (Dis)advantage: How Energy Ties and Task Conflict Help Clarify the Relationship Between Extraversion and Proactive Performance

While academic and practitioner literatures have proposed that extraverts are at an advantage in team-based work, it remains unclear exactly what that advantage might be, how extraverts attain such an advantage, and under which conditions. Theory highlighting the importance of energy in the coordination of team efforts helps to answer these questions. We propose that extraverted individuals are able to develop more energizing relationships with their teammates and as a result are seen as proactively contributing to their team. However, problems in coordination (i.e., team task conflict) can reverse this extraversion advantage. We studied 27 project-based teams at their formation, peak performance, and after disbandment. Results suggest that when team task conflict is low, extraverts energize their teammates and are viewed by others as proactively contributing to the team. However, when team task conflict is high, extraverts develop energizing relationships with fewer of their teammates and are not viewed as proactively contributing to the team. Our findings regarding energizing relationships and team task conflict clarify why extraversion is related to proactive performance and in what way, how, and when extraverts may be at a (dis)advantage in team-based work

Corporate social responsibility in Sri Lanka: The impact of government influence, societal expectations and the 2004 tsunami

This study examines government influence, changes in societal expectations and the 2004 tsunami on corporate social responsibility (CSR) in Sri Lanka, a developing country. Hypotheses are formulated based on legitimacy theory to examine the annual changes in total quantity and categories of CSR disclosures between 2004 and 2007. Four directional hypotheses are used to test the increase in CSR disclosures and the increase in category-specific CSR disclosures based on a disclosure classification system. A null hypothesis is used to test whether the change in CSR disclosures from 2004 to 2005 and from 2005 to 2006 remained relatively constant after 2006. The directional hypotheses and the null hypothesis on the extent of disclosure are supported but the category-specific hypotheses are rejcted. This result provides support for legitimacy theory

Ex vivo determination of bone tissue strains for an in vivo mouse tibial loading model

AbstractPrevious studies introduced the digital image correlation (DIC) as a viable technique for measuring bone strain during loading. In this study, we investigated the sensitivity of a DIC system in determining surface strains in a mouse tibia while loaded in compression through the knee joint. Specifically, we examined the effect of speckle distribution, facet size and overlap, initial vertical alignment of the bone into the loading cups, rotation with respect to cameras, and ex vivo loading configurations on the strain contour maps measured with a DIC system.We loaded tibiae of C57BL/6 mice (12 and 18 weeks old male) up to 12N at 8N/min. Images of speckles on the bone surface were recorded at 1N intervals and DIC was used to compute strains. Results showed that speckles must have the correct size and density with respect to the facet size of choice for the strain distribution to be computed and reproducible. Initial alignment of the bone within the loading cups does not influence the strain distribution measured during peak loading, but bones must be placed in front of the camera with the same orientation in order for strains to be comparable. Finally, the ex vivo loading configurations with the tibia attached to the entire mouse, or to the femur and foot, or only to the foot, showed different strain contour maps.This work provides a better understanding of parameters affecting full field strain measurements from DIC in ex vivo murine tibial loading tests

Changing physical conditions in star-forming galaxies between redshifts 0 < Z < 4: [O iii]/H beta evolution

We investigate the redshift evolution of the [O III]/H Β nebular emission line ratio for a sample of galaxies spanning the redshift range 0 < z < 4. We compare the observed evolution to a set of theoretical models which account for the independent evolution of chemical abundance, ionization parameter and interstellar medium (ISM) pressure in star-forming galaxies with redshift. Accounting for selection effects in the combined data sets, we show that the evolution to higher [O III]/H Β ratios with redshift is a real physical effect which is best accounted for by a model in which the ionization parameter is elevated from the average values typical of local star-forming galaxies, with a possible simultaneous increase in the ISM pressure. We rule out the possibility that the observed [O III]/H Β evolution is purely due to metallicity evolution. We discuss the implications of these results for using local empirical metallicity calibrations to measure metallicities at high redshift, and briefly discuss possible theoretical implications of our results

Radial Velocity Prospects Current and Future: A White Paper Report prepared by the Study Analysis Group 8 for the Exoplanet Program Analysis Group (ExoPAG)

[Abridged] The Study Analysis Group 8 of the NASA Exoplanet Analysis Group was convened to assess the current capabilities and the future potential of the precise radial velocity (PRV) method to advance the NASA goal to "search for planetary bodies and Earth-like planets in orbit around other stars.: (U.S. National Space Policy, June 28, 2010). PRVs complement other exoplanet detection methods, for example offering a direct path to obtaining the bulk density and thus the structure and composition of transiting exoplanets. Our analysis builds upon previous community input, including the ExoPlanet Community Report chapter on radial velocities in 2008, the 2010 Decadal Survey of Astronomy, the Penn State Precise Radial Velocities Workshop response to the Decadal Survey in 2010, and the NSF Portfolio Review in 2012. The radial-velocity detection of exoplanets is strongly endorsed by both the Astro 2010 Decadal Survey "New Worlds, New Horizons" and the NSF Portfolio Review, and the community has recommended robust investment in PRVs. The demands on telescope time for the above mission support, especially for systems of small planets, will exceed the number of nights available using instruments now in operation by a factor of at least several for TESS alone. Pushing down towards true Earth twins will require more photons (i.e. larger telescopes), more stable spectrographs than are currently available, better calibration, and better correction for stellar jitter. We outline four hypothetical situations for PRV work necessary to meet NASA mission exoplanet science objectives.Comment: ExoPAG SAG 8 final report, 112 pages, fixed author name onl

Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes.

BackgroundHuman papillomaviruses (HPV) cause over 500 000 cervical cancers each year, most of which occur in low-resource settings. Human papillomavirus genotyping is important to study natural history and vaccine efficacy. We evaluated TypeSeq, a novel, next-generation, sequencing-based assay that detects 51 HPV genotypes, in 2 large international epidemiologic studies.MethodsTypeSeq was evaluated in 2804 cervical specimens from the Study to Understand Cervical Cancer Endpoints and Early Determinants (SUCCEED) and in 2357 specimens from the Costa Rica Vaccine Trial (CVT). Positive agreement and risks of precancer for individual genotypes were calculated for TypeSeq in comparison to Linear Array (SUCCEED). In CVT, positive agreement and vaccine efficacy were calculated for TypeSeq and SPF10-LiPA.ResultsWe observed high overall and positive agreement for most genotypes between TypeSeq and Linear Array in SUCCEED and SPF10-LiPA in CVT. There was no significant difference in risk of precancer between TypeSeq and Linear Array in SUCCEED or in estimates of vaccine efficacy between TypeSeq and SPF10-LiPA in CVT.ConclusionsThe agreement of TypeSeq with Linear Array and SPF10-LiPA, 2 well established standards for HPV genotyping, demonstrates its high accuracy. TypeSeq provides high-throughput, affordable HPV genotyping for world-wide studies of cervical precancer risk and of HPV vaccine efficacy

Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2

Cardiac hypertrophy is a well-established risk factor for cardiovascular morbidity and mortality. Activation of $G_{q/11}$-mediated signaling is required for pressure overload-induced cardiomyocyte (CM) hypertrophy to develop. We previously showed that among Regulators of G protein Signaling, RGS2 selectively inhibits $G_{q/11}$ signaling and its hypertrophic effects in isolated CM. In this study, we generated transgenic mice with CM-specific, conditional RGS2 expression (dTG) to investigate whether RGS2 overexpression can be used to attenuate $G_{q/11}$-mediated signaling and hypertrophy in vivo. Transverse aortic constriction (TAC) induced a comparable rise in ventricular mass and ANF expression and corresponding hemodynamic changes in dTG compared to wild types (WT), regardless of the TAC duration (1-8 wks) and timing of RGS2 expression (from birth or adulthood). Inhibition of endothelin-1-induced $G_{q/11}$-mediated phospholipase C β activity in ventricles and atrial appendages indicated functionality of transgenic RGS2. However, the inhibitory effect of transgenic RGS2 on $G_{q/11}$-mediated PLCβ activation differed between ventricles and atria: (i) in sham-operated dTG mice the magnitude of the inhibitory effect was less pronounced in ventricles than in atria, and (ii) after TAC, negative regulation of $G_{q/11}$ signaling was absent in ventricles but fully preserved in atria. Neither difference could be explained by differences in expression levels, including marked RGS2 downregulation after TAC in left ventricle and atrium. Counter-regulatory changes in other $G_{q/11}$-regulating RGS proteins (RGS4, RGS5, RGS6) and random insertion were also excluded as potential causes. Taken together, despite ample evidence for a role of RGS2 in negatively regulating $G_{q/11}$ signaling and hypertrophy in CM, CM-specific RGS2 overexpression in transgenic mice in vivo did not lead to attenuate ventricular $G_{q/11}$-mediated signaling and hypertrophy in response to pressure overload. Furthermore, our study suggests chamber-specific differences in the regulation of RGS2 functionality and potential future utility of the new transgenic model in mitigating $G_{q/11}$ signaling in the atria in vivo

HIV prevalence and undiagnosed infection among a community sample of gay and bisexual men in Scotland, 2005-2011: implications for HIV testing policy and prevention

&lt;b&gt;Objective&lt;/b&gt;&lt;p&gt;&lt;/p&gt; To examine HIV prevalence, HIV testing behaviour, undiagnosed infection and risk factors for HIV positivity among a community sample of gay men in Scotland.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methods&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Cross-sectional survey of gay and bisexual men attending commercial gay venues in Glasgow and Edinburgh, Scotland with voluntary anonymous HIV testing of oral fluid samples in 2011. A response rate of 65.2% was achieved (1515 participants).&lt;p&gt;&lt;/p&gt; &lt;b&gt;Results&lt;/b&gt;&lt;p&gt;&lt;/p&gt; HIV prevalence (4.8%, 95% confidence interval, CI 3.8% to 6.2%) remained stable compared to previous survey years (2005 and 2008) and the proportion of undiagnosed infection among HIV-positive men (25.4%) remained similar to that recorded in 2008. Half of the participants who provided an oral fluid sample stated that they had had an HIV test in the previous 12 months; this proportion is significantly higher when compared to previous study years (50.7% versus 33.8% in 2005, p&#60;0.001). Older age (&#62;25 years) was associated with HIV positivity (1.8% in those &#60;25 versus 6.4% in older ages group) as was a sexually transmitted infection (STI) diagnosis within the previous 12 months (adjusted odds ratio 2.13, 95% CI 1.09–4.14). There was no significant association between age and having an STI or age and any of the sexual behaviours recorded.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusion&lt;/b&gt;&lt;p&gt;&lt;/p&gt; HIV transmission continues to occur among gay and bisexual men in Scotland. Despite evidence of recent testing within the previous six months, suggesting a willingness to test, the current opt-out policy may have reached its limit with regards to maximising HIV test uptake. Novel strategies are required to improve regular testing opportunities and more frequent testing as there are implications for the use of other biomedical HIV interventions.&lt;p&gt;&lt;/p&gt

ACOUSTIC CROSS-OVER BETWEEN THE EARS IN MICE (Mus musculus) DETERMINED USING A NOVEL ABR BASED BIO-ASSAY

ABSTRACT Closed-field stimulation of one ear, at high sound intensity, will activate both ears because of bone/soft tissue transmission of the acoustic signal across the skull. In human psychophysics and in clinical audiometry a knowledge of interaural attenuation values is important, particularly when assessing asymmetrical hearing loss or in studies of monaural hearing. Similarly, in testing monaural hearing in experimental animal studies, acoustic cross-over can result in erroneous conclusions about hearing function. The mouse has become a widely used animal model for various types of hearing loss, especially those relating to gene mutations, and also for age related deafness (presbycusis). In the present study we have measured acoustic cross-over in this species using a novel bio-assay technique based on auditory brainstem evoked responses (ABR). We report here for the mouse, an interaural attenuation of 37-45dB for click and 32kHz toneburst SOMMAIRE La stimulation de l&apos;oreille unique à haute intensité sonore, en sphère fermée, cause l&apos;activation des deux oreilles dù à la transmission du signal acoustique a travers les tissus mous et l&apos;os du crâne. En psychophysique de l&apos;homme et l&apos;audiométrie clinique, l&apos;atténuation interaural doit être connue dans les études d&apos;audience mono ou de la surdité asymétrique. De même, pour tester l&apos;audition monaurale dans les études expérimentales chez les animaux, la transmission trans-crânienne (aguillage acoustique) peut produire des conclusions erronées au sujet de la fonction auditive. La souris est devenue le modèle animal largement utilisé pour différents types de pertes auditives, en particulier celles qui ont a trait à des mutations géniques, et aussi de la surdité liée à l&apos;âge (presbyacousie). Dans l&apos;étude en question, nous avons mesuré la transmission trans-crânienne (aguillage acoustique) chez cette espèce en utilisant une technique de dosage biologique basée sur les potentiels évoqués auditifs (PEA). Nous rapportons ici chez la souris, une atténuation interaural de 37-45dB pour le clic et le 32kHz pip tonal