Expertise coordination in information systems development projects: Willingness, ability, and behavior

[[abstract]]Information systems development (ISD) projects are complex, requiring a variety of expertise. Coordinating such expertise helps manage complexity, increasing the likelihood of a project's success. Findings of past studies have been inconsistent regarding the benefits of expertise coordination—perhaps, in part, because three different forms of coordination have been used: willingness, ability, and behavior. We find that willingness and ability are antecedents of coordination behavior, and that coordination behavior fully mediates different forms of project success. Thus, successful expertise coordination requires team members who are both willing and able. The implications and limitations of this study are discussed.[[notice]]補正完

A common variant mapping to <i>CACNA1A </i>is associated with susceptibility to exfoliation syndrome

Author manuscript available from PMC http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605818/Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) of 1,484 cases and 1,188 controls from Japan and followed up the most significant findings in a further 6,901 cases and 20,727 controls from 17 countries across 6 continents. We discovered a genome-wide significant association between a new locus (CACNA1A rs4926244) and increased susceptibility to XFS (odds ratio (OR) = 1.16, P = 3.36 × 10−11). Although we also confirmed overwhelming association at the LOXL1 locus, the key SNP marker (LOXL1 rs4886776) demonstrated allelic reversal depending on the ancestry group (Japanese: ORA allele = 9.87, P = 2.13 × 10−217; non-Japanese: ORA allele = 0.49, P = 2.35 × 10−31). Our findings represent the first genetic locus outside of LOXL1 surpassing genome-wide significance for XFS and provide insight into the biology and pathogenesis of the disease