Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Frutas como fuentes de moléculas bioactivas

La naturaleza nos proporciona una gran cantidad de especiesvegetales frutales con interesantes propiedades biológicas,las cuales son una fuente importante de nuevas moléculasbioactivas, que pueden reemplazar a los químicos sintéticos,ya que son amigables con el medio ambiente y son menostóxicos. Actualmente existen más de 30.000 publicacionesen las que las frutas están relacionadas con alguna actividadbiológica, según la búsqueda realizada en diferentes basesde datos hasta julio de 2019. Esto confirma la amplia utilidadde las frutas como principal fuente de metabolitos bioactivos,que pueden ser utilizados como principios activos en diferentesproductos de gran utilidad para la humanidad

Frutas como fuentes de moléculas bioactivas

La naturaleza nos proporciona una gran cantidad de especiesvegetales frutales con interesantes propiedades biológicas,las cuales son una fuente importante de nuevas moléculasbioactivas, que pueden reemplazar a los químicos sintéticos,ya que son amigables con el medio ambiente y son menostóxicos. Actualmente existen más de 30.000 publicacionesen las que las frutas están relacionadas con alguna actividadbiológica, según la búsqueda realizada en diferentes basesde datos hasta julio de 2019. Esto confirma la amplia utilidadde las frutas como principal fuente de metabolitos bioactivos,que pueden ser utilizados como principios activos en diferentesproductos de gran utilidad para la humanidad