1,132 research outputs found
Impartiality, Objectivity, and Political Engagement in Nineteenth-Century French Historiography:Monod and the Dreyfus Affair
Impartiality, Objectivity, and Political Engagement in Nineteenth-Century French Historiography:Monod and the Dreyfus Affair
«Histoire, mémoire de l’humanité»: l’influence de Bergson sur la conception de l’histoire et celle de la mémoire de Charles Péguy
[Bespreking van: J. Tollebeek, H. te Velde (2009) Het geheugen van de Lage Landen; J. Tollebeek (2008) België, een parcours van herinnering. - 1: Plaatsen van geschiedenis en expansie; J. Tollebeek (2008) België, een parcours van herinnering. - 2: Plaatsen van tweedracht, crisis en nostalgie; W. van den Doel (2005) Nederland in de twintigste eeuw; J. Bank, M. Mathijsen (2006) Nederland in de negentiende eeuw; M. Prak (2006) Nederland in de zeventiende en achttiende eeuw; W. Blockmans, H. Pleij (2007) Nederland van prehistorie tot Beeldenstorm]
PLASMA-ENHANCED CHEMICAL VAPOUR DEPOSITION ON PARTICLES IN AN ATMOSPHERIC CIRCULATING FLUIDIZED BED
Plasma-enhanced chemical vapour deposition is an attractive technqiue to provide particles with a thin film. Applying a cold plasma enables us to work with temperature-sensitive materials. Using a CFB with an incorporated volume dielectric barrier discharge reactor we coated 20-30 m CuO particles with a thin SiOx layer
A RNA Interference Screen Identifies the Protein Phosphatase 2A Subunit PR55γ as a Stress-Sensitive Inhibitor of c-SRC
Protein Phosphatase type 2A (PP2A) represents a family of holoenzyme complexes with diverse biological activities. Specific holoenzyme complexes are thought to be deregulated during oncogenic transformation and oncogene-induced signaling. Since most studies on the role of this phosphatase family have relied on the use of generic PP2A inhibitors, the contribution of individual PP2A holoenzyme complexes in PP2A-controlled signaling pathways is largely unclear. To gain insight into this, we have constructed a set of shRNA vectors targeting the individual PP2A regulatory subunits for suppression by RNA interference. Here, we identify PR55γ and PR55δ as inhibitors of c-Jun NH2-terminal kinase (JNK) activation by UV irradiation. We show that PR55γ binds c-SRC and modulates the phosphorylation of serine 12 of c-SRC, a residue we demonstrate to be required for JNK activation by c-SRC. We also find that the physical interaction between PR55γ and c-SRC is sensitive to UV irradiation. Our data reveal a novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55γ
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