Community In Liberalism: Language Rights In Quebec

To what extent can liberal theory account for community without compromising its core value, that of autonomy? And, by extension, can a liberal framework of rights properly integrate claims to the promotion of community, say a linguistic community? Part of the answer rests on an interpretation of liberalism which would accommodate community and valid claims to communal goods such as language. Various attempts to offer such an interpretation, however, are constrained by normative claims about the primacy of autonomy, or yet are founded on shaky propositions about the moral status of community. These difficulties are apparent in rights-discourse, namely in debates concerning collective rights. This thesis examines how this problem manifests itself in issues concerning language rights in Quebec, and proposes elements of a conceptual approach that could account for strong language rights such as Bill 101. It involves construing identity as a substantive value on which such communal rights can be founded, and from which we can manage the inevitable tension with more traditional individual rights based on the value of autonomy

Hermetic Imagination: The Effect of The Golden Dawn on Fantasy Literature

The Hermetic Order of the Golden Dawn was an English expression of the Nineteenth-Century occult revival in Europe. Dedicated to such practices as ceremonial magic and divination, it valued these more as gateways to true understanding of reality than for their intrinsic merit. The Golden Dawn’s essentially Neoplatonic world-view is reflected in the writings of such some-time members as W.B. Yeats, Arthur Machen and Charles Williams

Biological Action of Mycotoxins

Mycotoxins are ubiquitous, mold-produced toxins that contaminate a wide variety of foods and feeds. Ingestion of mycotoxins cause a range of toxic responses, from acute toxicity to long-term or chronic health disorders. Some mycotoxins have caused outbreaks of human toxicoses, and at least one mycotoxin, aflatoxin B1, is a presumed human hepatocarcinogen. As part of a comprehensive effort to curtail the adverse health effects posed by mycotoxins, substantial research has been conducted to determine the mechanism of action of mycotoxins in animals. This review presents some of the current knowledge on the biological action of four diverse classes of mycotoxins—aflatoxin B1, tricothecenes, zearalenone, and fumonisin B1—with particular emphasis on mechanisms of action

SKPing a Hurdle: Sox2 and Adult Dermal Stem Cells

In this issue of Cell Stem Cell, Biernaskie et al. (2009) demonstrate that a specific subpopulation of dermal papilla fibroblasts, marked by Sox2 expression, displays properties of adult stem cells, including serial hair follicle initiation, dermal cell differentiation, and skin-derived precursor production

Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair

The ability to heal wounds is vital to all organisms. In mammalian tissues, alterations in intermediate filament (IF) gene expression represent an early reaction of cells surviving injury. We investigated the role of keratin IFs during the epithelialization of skin wounds using a keratin 6α and 6β (K6α/K6β)-null mouse model. In skin explant culture, null keratinocytes exhibit an enhanced epithelialization potential due to increased migration. The extent of the phenotype is strain dependent, and is accompanied by alterations in keratin IF and F-actin organization. However, in wounded skin in vivo, null keratinocytes rupture as they attempt to migrate under the blood clot. Fragility of the K6α/K6β-null epidermis is confirmed when applying trauma to chemically treated skin. We propose that the alterations in IF gene expression after tissue injury foster a compromise between the need to display the cellular pliability necessary for timely migration and the requirement for resilience sufficient to withstand the rigors of a wound site

Effects of chloride ion substitutes and chloride channel blockers on the transient outward current in rat ventricular myocytes

AbstractThe Cai2-insensitive transient outward current, ilo was studied at 20–24°C in rat ventricular myocytes with the whole cell recording patch-clamp technique. The current was recorded before and after replacement of chloride by methanesulfonate or aspartate or in the absence and the presence of chloride channel blockers, SITS or 9-anthracene carboxylic acid. In control conditions (in the presence of external divalent cations, Ca2+ and Cd2+, Cd2+ being used to suppress Ca2+ current), ilo inactivation was composed of a fast and a slow component. When methanesulfonate was substituted for external Cl− the peak current decreased to a variable extent, but the inactivation of the remaining current was still composed of a fast and a slow component. In contrast, the inactivation of the difference current was well fitted by a single exponential. The time to peak of the difference current was shorter than that of the current recorded either in the absence or the presence of methanesulfonate. Both activation- and steady-state inactivation-voltage curves were either unchanged (n = 4) or shifted by a few mV (5.5 mV, n = 14) towards positive potentials when methanesulfonate was substituted for Cl− The current remaining in methanesulfonate reversed at potentials closed to EK. The difference current was composed of a peak and a steady-state component. The peak was suppressed by 4-aminopyridine whereas the steady-state component was not. The peak was also suppressed when pipette solution contained Cs+ instead of K+ but was still present when the Hepes concentration in both external and pipette media was increased 5-fold (50 mM vs. 10 mM). When aspartate was substituted for Cl− or when 2 mM SITS was added to the external solution (in the absence of Ca2+ and Cd2+ because aspartate is known to chelate Ca2+ ions and possibly other divalent cations), ilo was reduced to a similar extent in the two cases and the difference current was composed of a peak (inactivation fitted by a single exponential) and a steady-state component. The SITS-sensitive transient current reversed at a potential close to ECl When 5 mM 9-anthracene carboxylic acid was added to external solution (in the presence of Ca2+ and Cd2+), the peak of the difference current was similar to that observed when Cl− was substituted by methanesulfonate. The difference current resulting from the substitution of methanesulfonate for chloride was not changed when the pipette solution contained either 50 mM EGTA (instead of 5 mM) or 10 mM EGTA and 10 mM BAPTA. The nature of Cs+- and 4-aminopyridine-sensitive transient outward current suppressed by chloride ion substitutes or chloride channel blockers is discussed