152 research outputs found
Recommended from our members
Spring 1969
Design Features the Golfer Wants by Geoffrey S. Cornish & William G. Robinson (page 3) How Water Moves in the Soil by Walter H. Gardner (6) Course Care in Winter (8) Spray-on Protein Boosters by S. K. Ries (9) 1969 Turf Conference Program (12) How to Get More Benefits from Our Next Conference (13) Budget Control by Ken Voorhies (15) Turf Analysis Test by Dale Kern (18) Tolerance of Various Turfgrasses to Foliar Applications of Road Salt by W.E. Cordukes (22) He \u27Fitz\u27 the Bill by Gerry Finn (24
Recommended from our members
March 1965
Turf and Lawn Grass Association
Better turf through research and Educatio
Recommended from our members
Summer 1967
Massachusetts Turf and Lawn Grass CouncilBetter Turf Through Research and Educatio
Recommended from our members
1961
My Ideal Course, Underwater, U.S.A. (page 1) From the Editor (3) Turf Management Club News (3) Quotes from 1961 Seniors (4) The United States Most Western Owned Golf Course: Armed Forces Golf Course, Guam (5) Turf Majors Participate in Horticultural Show (7) Picture - G.C.S.A Scholarships Awarded to Three Turf Seniors (8) Picture - Stockbridge - Majors in turf Management (9) Opportunity and Education (10) The Most Outstanding Turf Senior for the Year - 1961 (11) How We Prepare Our Greens Before Topdressing (12) An Inexpensive Cure for Weeds and Poa Annua (13) Watering (14) Picture - Honorary Members of the Turf Management Club (16) Picture - Graduates of Winter School for Turf Managers - 1961 (17) Welcome Speech by Narry Sperandio (A-1) Handle with Care by Dr. Ellsworth H. Wheeler (A-2) Current Ideas on Green Construction - Panel Discussion (A-4) Automatic Systems for Watering by Robert F. Harper (A-14) History of Golf Course Architecture by Geoffrey S. Cornish (A-22) Effect of Nutrition on Turf Diseases by Dr. Houston B. Couch Turf Disease Control and Use of Fungicides by Dr. R. J. Lukens Trees and Tree Care by Gordon S. King (A-38) Arsenical Toxicity by Dr. C. R. Skogley (A-41) Soil Reaction to Arsenical Compounds by Joseph E. Steckel Brush Control For the Golf Course by Dr. William I. Boyd (A-51) Massachusetts Highway Herbicide Program by Joseph L. Beasley (A-54) General Turf (Alternate Session): Observations on Highway Turf Establishment & Maintenance by E.F. Button (A-62) Pre-emerge Chemicals for the Control of Crabgrass by Dr. John R. Havis, John M. Zak & Joseph Troll (A-70) Root Growth of Turf Grasses as Affected by Different heights of Cut and Nutrient Levels by Evangel J. Bredakis (A-71) The Use of Sod by Daniel Pellegrino (A-72
Recommended from our members
1962
Turf on the Launching Pad (page 1) Turf management Club News (3) Education, Experience and Attitude (4) A Blade of Grass (5) Picture - Professor Lawrence S. Dickinson (6) Picture - Thomas Mascaro - Banquet Speaker (7) Planting Trees on the Golf Course (8) Two-Way Radios (8) Greens Mowing Procedure (9) Watering and Topdressing as Related to Poa annua Infestations (10) Picture - Stockbridge Majors in Turf Management (12) Picture - Graduates of Winter School for Turf Managers - 1962 (13) Review of Season\u27s Pests by Joseph Troll (A-1) Today\u27s Trends in Golf Course Development by Col. Harry C. Eckoff (A-3) Breeding and Selection of Fine Turf Grasses by Dr. B. R. Anderson Penncross Bentgrass by J. Dutch(A-13) Poa annua by Alexander Radko (A-16) Velvet Bent by Jesse DeFrance (A-19) Vegetative Creeping Bentgrasses by Fred Grau (A-21) Modification of SOils for Green Construction & Top Dressing by Prof. H. B. Musser (A-27) Soil COmpaction by Donald Waddington (A-32) Irrigation Practices and the Need of Basic Research by Prof. Edward PIra (A-36) Water Sources by Z. Mills (A-39) Athletic Field Maintenance by Thomas Mascaro (A-41) Planning the Landscape Around the House by Prof. Harold Mosher (A-43
Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2
The Omicron strains of SARS-CoV-2 pose a significant challenge to the development of effective antibody-based treatments as immune evasion has compromised most available immune therapeutics. Therefore, in the ‘arms race’ with the virus, there is a continuing need to identify new biologics for the prevention or treatment of SARS-CoV-2 infections. Here, we report the isolation of nanobodies that bind to the Omicron BA.1 spike protein by screening nanobody phage display libraries previously generated from llamas immunized with either the Wuhan or Beta spike proteins. The structure and binding properties of three of these nanobodies (A8, H6 and B5-5) have been characterized in detail providing insight into their binding epitopes on the Omicron spike protein. Trimeric versions of H6 and B5-5 neutralized the SARS-CoV-2 variant of concern BA.5 both in vitro and in the hamster model of COVID-19 following nasal administration. Thus, either alone or in combination could serve as starting points for the development of new anti-viral immunotherapeutics
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