22 research outputs found
Safety and Benefit of Discontinuing Statin Therapy in the Setting of Advanced, Life-Limiting Illness: A Randomized Clinical Trial
For patients with limited prognosis, some medication risks may outweigh the benefits, particularly when benefits take years to accrue; statins are one example. Data are lacking regarding the risks and benefits of discontinuing statin therapy for patients with limited life expectancy
Dry, hydrophobic microfibrillated cellulose powder obtained in a simple procedure using alkyl ketene dimer
Convenience of immobilizedBacillus licheniformis α-amylase as time—temperature-integrator (TTI)
X-ray structural analysis of trans-1-Ethyl-2-(1-ethyl-2-adamantylidene)-adamantane. Comparison with force field calculations
Polyphenoloxidase Activity and Color of Blanched and High Hydrostatic Pressure Treated Banana Puree
THEORETICAL CONSIDERATIONS ON DESIGN of MULTICOMPONENT TIME TEMPERATURE INTEGRATORS IN EVALUATION of THERMAL PROCESSES
Industrially Relevant Canning Trials with a Sterilisation Time–Temperature Integrator
Food sterilisation, i.e. heating to above 120 °C for several min, still remains a primary method of food preservation. Current time-temperature integrators (TTIs), used to assess the thermal impact, only work at pasteurisation temperatures (below 100 °C). The aim of this work was to develop and validate a sterilisation TTI using an α-amylase from the hyperthermophile Pyrococcus furiosus. Previous experiments have found that this α-amylase has a z value similar to that of Clostridium botulinum spores and the enzyme is sufficiently heat resistant to show a measurable residual activity after 30 min at 121 °C. Analysis found a D value of 24 min and a slightly variable z value of around 11 °C. The decrease in enzymatic activity from thermal processing was found after a F121°C process of 5 min to be 67 %, and for a F121°C of 30 min it was 12 %, thus making P. furiosus α-amylase a strong and relevant candidate for a sterilisation TTI. Trials with canned water and mango chutney as test materials have confirmed the potential application of the enzyme within an industrially relevant setting of a model reel and spiral retort. The thermal data showed that at low or marginal F121°C values, of less than 15 min, the correlation between the TTI and thermocouple data was closely comparable (R 2 = 0.96). The applicability of these TTIs over the range of industrial processes is also shown.</p