Ejection Forces and Friction Coefficients from Injection Molding Experiments Using Rapid Tooling Inserts

Experiments have been performed with injection mold inserts made using solid freeform fabrication processes in an effort to further study such applications for economic production of small quantities of parts. Static friction coefficients were determined for HDPE and HIPS against P-20 steel, sintered LaserForm ST-100, and stereolithography SL 5170 using the ASTM D 1894 standard. Injection mold inserts were constructed of the same three materials and were used to inject cylindrical parts using HDPE and HIPS. Ejection forces were measured, and a model was used to calculate ejection forces and apparent coefficients of static friction. Statistical analyses were used to determine the effects of packing time, cooling time and packing pressure on ejection force for the three insert types. This paper compares experimental and calculated ejection forces, compares standard friction test results to calculated apparent coefficients of friction, summarizes the statistical results, and comments on the feasibility of using rapid tooled inserts for injection molding.Mechanical Engineerin

Operation of a forced circulation, croloy 9 m, mercury loop to study corrosion product separation techniques

Forced circulation, Croloy 9M mercury loop designed to investigate corrosion product separation technique

Observation of narrow-band noise accompanying the breakdown of insulating states in high Landau levels

Recent magnetotransport experiments on high mobility two-dimensional electron systems have revealed many-body electron states unique to high Landau levels. Among these are re-entrant integer quantum Hall states which undergo sharp transitions to conduction above some threshold field. Here we report that these transitions are often accompanied by narrow- and broad-band noise with frequencies which are strongly dependent on the magnitude of the applied dc current.Comment: 4 pages, 3 figure

Preliminary evidence supports circulating microRNAs as prognostic biomarkers for type 2 diabetes.

Background:Circulating microRNAs are emerging as potential prognostic biomarkers for the development of type 2 diabetes. However, microRNAs are also associated with complications from impaired glucose metabolism (e.g. endothelial cell function). Prior studies have not evaluated for associations between trajectories of circulating microRNAs with trajectories of fasting blood glucose over time and the responses to behavioral interventions to reduce risk. This study performed longitudinal assessment of microRNAs and fasting blood glucose and identified relationships between microRNAs and behavioral risk reduction interventions. Methods:MicroRNAs (n = 353) were measured in subsets (n = 10, n = 8) of participants from previously completed clinical trials that studied behavioral risk reduction interventions. Fasting blood glucose trajectories were associated with changes in 45 microRNAs over 12 months. Results:Following a 3-month physical activity and dietary intervention compared with baseline, 13 microRNAs were differentially expressed. Seven microRNAs (i.e. miR-106b, miR-20b, miR-363, miR-486, miR-532, miR-92a and miR-93) were commonly identified between the two analyses. Conclusions:Further studies are needed to determine which microRNAs are prognostic biomarkers of risk for type 2 diabetes versus consequences of impaired glucose metabolism. Additional future directions of this research are to differentiate whether microRNAs are prognostic and/or diagnostic biomarkers for risk for type 2 diabetes and predictive biomarkers of responses to risk reduction interventions

Human myiasis in Ecuador.

We review epidemiological and clinical data on human myiasis from Ecuador, based on data from the Ministry of Public Health (MPH) and a review of the available literature for clinical cases. The larvae of four flies, Dermatobia hominis, Cochliomyia hominivorax, Sarcophaga haemorrhoidalis, and Lucilia eximia, were identified as the causative agents in 39 reported clinical cases. The obligate D. hominis, causing furuncular lesions, caused 17 (43.5%) cases distributed along the tropical Pacific coast and the Amazon regions. The facultative C. hominivorax was identified in 15 (38%) clinical cases, infesting wound and cavitary lesions including orbital, nasal, aural and vaginal, and occurred in both subtropical and Andean regions. C. hominivorax was also identified in a nosocomial hospital-acquired wound. Single infestations were reported for S. haemorrhoidalis and L. eximia. Of the 39 clinical cases, 8 (21%) occurred in tourists. Ivermectin, when it became available, was used to treat furuncular, wound, and cavitary lesions successfully. MPH data for 2013–2015 registered 2,187 cases of which 54% were reported in men; 46% occurred in the tropical Pacific coast, 30% in the temperate Andes, 24% in the tropical Amazon, and 0.2% in the Galapagos Islands. The highest annual incidence was reported in the Amazon (23 cases/100,000 population), followed by Coast (5.1/100,000) and Andes (4.7/100,000). Human myiasis is a neglected and understudied ectoparasitic infestation, being endemic in both temperate and tropical regions of Ecuador. Improved education and awareness among populations living in, visitors to, and health personnel working in high-risk regions, is required for improved epidemiological surveillance, prevention, and correct diagnosis and treatment