Effect of edaravone on lungs and small intestine in rats with induced radiotherapy

Radiotherapy is a frequently used method for treatment of cancer which is regarded as one of the top two diseases causing premature death worldwide. However, radiotherapy is known to have many side effects. In this study, we evaluated biologically and histologically the possible protective effects of edaravone, the free radical scavenger and neuroprotective agent used to treat amyotrophic lateral sclerosis, on lung and small intestine against radiation-induced early side effects of 15 Gy total body irradiation in single fraction. Thirty-two rats were divided randomly into four equal groups. Groups were administered 15 Gy of external ionizing radiation to the whole body after 30 minutes of EDA administration (a dose of 500 and 50 mg/kg). Rats were sacrified at 72 h of the experiment. Tissues were separated to investigate levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPX) and malondialdehyde (MDA); and evealuate histopathological changings. The protective effect of EDA showed statistically significant in MDA, SOD and GSHPX values of lungs except CAT and statistically significant effect was observed in MDA in small intestine. Also, we showed statistically significant values with histopathological changings. Pediatric cancer patients who have a longer life expectancy are as important as their recovery from their normal life. We are expecting that EDA as a modulator of free radical scavenging pathways in many organs can reduce the side effects of radiation damage on lungs and small intestine

Surgical Approach to Non-Parasitic Splenic Cysts in Childhood

WOS: 000573105000006Objective: in our study, we aimed to demonstrate and evaluate our surgical approaches to childhood non-parasitic splenic cysts comparatively. Methods: Patients who underwent surgery for non-parasitic splenic cysts between 2012 and 2017 were retrospectively analyzed. the cases were evaluated in terms of age, gender, surgical method, pathological diagnosis and follow-up. Results: the mean age of eight patients (5 girls, 3 boys) who underwent surgery for non-parasitic splenic cyst was 15 years (minimum-maximum: 9-18 years). Partial splenectomy was performed in five cases (62.5%), and total splenectomy was performed in three cases (38.5%). the operation times are 75-90 minutes in total; It ranged from 60 to 75 minutes in partial splenectomies. Complications were not observed in any of the cases and there was not bleeding to require blood transfusion. Considering the pathology results, it was reported as epithelial cyst in four cases (50%), pseudocyst in three cases (37.5%) and mesothelial cyst in one case (12.5%). Ultrasound control was recommended to the patients every six months, and no recurrence has been observed until now. Conclusion: the spleen is a very important organ for the immune system, especially in children. Therefore, in the surgical treatment of non-parasitic splenic cysts, the spleen-sparing surgery option can be considered primarily if the location and size of the cyst are appropriate