An Investigation of Receptive and Expressive Pluralization and Tense Inflectional Skills of Three Year Old Children

No abstract provided by author

An Investigation of Receptive and Expressive Pluralization and Tense Inflectional Skills of Three Year Old Children

No abstract provided by author

SpMyb functions as an intramodular repressor to regulate spatial expression of CyIIIa in sea urchin embryos

The CyIIIa actin gene of Strongylocentrotus purpuratus is transcribed exclusively in the embryonic aboral ectoderm, under the control of 2.3 kb cis-regulatory domain that contains a proximal module that controls expression in early embryogenesis, and a middle module that controls expression in later embryogenesis. Previous studies demonstrated that the SpRunt-1 target site within the middle module is required for the sharp increase in CyIIIa transcription which accompanies differentiation of the aboral ectoderm, and that a negative regulatory region near the SpRunt-1 target site is required to prevent ectopic transcription in the oral ectoderm and skeletogenic mesenchyme. This negative regulatory region contains a consensus binding site for the myb family of transcription factors. In vitro DNA-binding experiments reveal that a protein in blastula-stage nuclei interacts specifically with the myb target site. Gene transfer experiments utilizing CyIIIa reporter constructs containing oligonucleotide substitutions indicate that this site is both necessary and sufficient to prevent ectopic expression of CyIIIa. Synthetic oligonucleotides containing the myb target site were used to purify a protein from sea urchin embryo nuclear extracts by affinity chromatography. This protein is immunoprecipitated by antibodies specific to the evolutionarily conserved myb domain, and amino acid sequences obtained from the purified protein were found to be identical to sequences within the myb domain. Sequence information was used to obtain cDNA clones of SpMyb, the S. purpuratus member of the myb family of transcription factors. Through interactions within the middle module, SpMyb functions to repress activation of CyIIIa in the oral ectoderm and skeletogenic mesenchyme

Global Insanity Redux

In our book Global Insanity we argued that the existential predicament faced by humanity is a predictable consequence of Western Enlightenment thinking and the resulting world model, whose ascendance with the Industrial Revolution entrained development of the global consumer Economy that is destroying the biosphere. This situation extends from a dominant mindset based on the philosophy of reductionism.  The problem was recognized and characterized by Robert M. Hutchins.  In 1985, Hutchins ideas were discussed by Robert Rosen in Chapter 1 of Anticipatory Systems: Philosophical, Mathematical & Methodological Foundations.  Building on Hutchins' ideas, Rosen laid the foundation for an entire new, non-reductionist paradigm, which he called "complexity theory".  This new paradigm is what we are further developing here.  One has to recognize that a paradigm shift is needed to overcome the entrenched mindset and world model that reductionism has created. Here we explore the myriad interconnected ways-psychological, social, cultural, political, and technological-that the Western world model and consumer economy works as a complex system to thwart, neutralize, or co-opt for its own ends any effort to bring about the kind of radical change that is needed to avert global ecological catastrophe and societal collapse. This resistance to change stems from the need, inherent in the Western model, to continually grow the consumer economy.  The media's continued portrayal of consumptive economic growth as a good thing, the widely held belief that the Economy is paramount, and current political and technological trends all manifest the system's active resistance to change. From the perspective of the mature economic system, any work that does not serve to grow the Economy is counterproductive, and viewed as unnecessary, a luxury, or subversive. The potential for real change (i.e. toward creation of a better system) is thus inversely related to the viability of the Economy, which will eventually decline as the system develops into senescence. To the extent that the fragile metastability of senescence affords opportunity for radical change, economic decline can be viewed as a hopeful sign. But taking maximum advantage of that opportunity will be extraordinarily difficult, as it will require widespread recognition of the problem, major voluntary sacrifice by the relatively large numbers of people who still benefit from the system (including what remains of the "middle class"), and concerted "grassroots" efforts.  It can be expected that the system will resist those efforts until the end, becoming increasingly reliant on media-enabled distraction and divisive politics, as well as violent coercion, to maintain itself.  Investment in education and science is widely touted as necessary for improving our situation, but this is misguided as long as the educational system and scientific enterprise continue to work in collusion with the larger system, as they currently do. Until the reductionist mindset and world model that drives the system is effectively challenged, there can be little hope for the kind of change needed to avert the catastrophic collapse of civilization

Health hints for your horse (1993)

One of the real disappointments of horse ownership is planning a number of horse activities, then finding that your animal is physically incapable or mentally unwilling to engage in them. Horse owners who don't practice "preventive maintenance" may find themselves in this situation. This publication describes illnesses and injuries that horse owners should mindful of

The Effects of Chronic Cortisol Exposure on the Innate Immune Response of Larval Danio Rerio

Chronic stress is known to cause a variety of health complications linked to a dysregulated immune response, which could be an outcome of chronically elevated stress signaling mediated by the glucocorticoid steroid hormone cortisol. Previous research has shown that zebrafish embryos treated with cortisol for the first 5 days of development matured into pro- inflammatory adults with atypical regulation of immune-related genes (Hartig et al., 10.1242/ bio.020065, 2016). The purpose of this study was to determine how chronic exposure to cortisol affects the innate immune response in larval zebrafish. To that end, the migration of neutrophils and macrophages were monitored following tail fin amputation. Results from this study provide evidence that cortisol-treated larvae had an increased number of macrophages near the amputation site, while the number of neutrophils was not significantly affected by cortisol exposure. These results suggest that chronically elevated glucocorticoid signaling specifically up-regulates the macrophage response to injury

The Influence of the Bible in the Building of America

https://digitalcommons.acu.edu/crs_books/1187/thumbnail.jp

The New Boston High School Symphonic Band: A Guest Recital

This is the program for the guest recital of The New Boston High School Symphonic Band, directed by James Coffman and Margie Manning. The recital was held on February 11, 1997, in the Jones Performing Arts Center