¿Pueden las restauraciones de resina bulk-fill ser una alternativa a las restauraciones de cemento de ionómero de vidrio modificado con resina en los molares primarios en niños preescolares? Un protocolo de ensayo clínico aleatorizado

Background: The aim of this study was to elaborate a randomized clinical trial protocol to evaluate the effectiveness of class I restorations in resin-modified glass ionomer cement (RMGIC) and bulk-fill resin in primary molars with untreated early childhood caries in toddlers. Material and Methods: A total of 59 toddlers up to 36 months old with at least two primary molar teeth with untreated dental caries of single surface on different sides of the mouth will be selected at the Pediatric Dentistry Clinics of the Faculty of Dentistry at Federal University of Minas Gerais (UFMG), Brazil. Teeth with untreated dental caries in the left and right sides of each patient’s mouth will be randomly distributed into 2 groups: Group 1 (Control): encapsulated RMGIC restoration with Riva light cure (SDI, Florida, USA) and Group 2 (Test): Filtek bulk-fill composite resin restoration (3M/ESPE, St. Paul, USA) with universal single bond adhesive system (3M/ESPE, St. Paul, USA). A single trained dentist will perform all restorative procedures. The restorations will be evaluated after 1, 6, 12, 18 and 24 months by two trained and calibrated examiners. Cost-efficacy analysis will be carried out. Kaplan-Meier survival analysis, Log-rank test, Cox regression, Poisson regression analysis, Mann-Whitney test or Kruskal-Wallis will be performed to analyze data. Conclusion: The protocol will make it possible to determine the most efficacy material for the restoration of cavities in cavities in primary molars of toddlers.Antecedentes: El objetivo de este estudio fue elaborar un protocolo de ensayo clínico aleatorizado para evaluar la efectividad de las restauraciones de clase I en cemento de ionómero de vidrio modificado con resina (RMGIC) y resina bulk-fill en molares primarios con caries de la primera infancia no tratadas en niños preescolares. Material y Métodos: Un total de 59 niños de hasta 36 meses de edad con al menos dos molares temporales con caries no tratada de superficie única en diferentes lados de la boca serán seleccionados en las Clínicas de Odontología Pediátrica de la Facultad de Odontología de la Universidad Federal de Minas Gerais (UFMG), Brasil. Los dientes con caries no tratada en los lados izquierdo y derecho de la boca de cada paciente se distribuirán aleatoriamente en 2 grupos: Grupo 1 (Control): restauración RMGIC encapsulada con fotopolimerización Riva (SDI, Florida, EE. UU.) Y Grupo 2 (Prueba): Restauración de resina compuesta bulk-fill Filtek (3M / ESPE, St. Paul, EE. UU.) con sistema adhesivo de unión simple universal (3M / ESPE, St. Paul, EE. UU.). Un solo dentista capacitado realizará todos los procedimientos de restauración. Las restauraciones serán evaluadas después de 1, 6, 12, 18 y 24 meses por dos examinadores capacitados y calibrados. Se llevará a cabo un análisis de coste-eficacia. Se realizarán análisis de supervivencia de Kaplan-Meier, prueba de rango logarítmico, regresión de Cox, análisis de regresión de Poisson, prueba de Mann-Whitney o Kruskal-Wallis para analizar los datos. Conclusión: El protocolo permitirá determinar el material más eficaz para la restauración de caries en molares temporales de niños preescolares

Can bulk-fill resin restorations be an alternative to resin-modified glass ionomer cement restorations in primary molars of toddlers? A randomized clinical trial protocol

Background: The aim of this study was to elaborate a randomized clinical trial protocol to evaluate the effectiveness of class I restorations in resin-modified glass ionomer cement (RMGIC) and bulk-fill resin in primary molars with untreated early childhood caries in toddlers. Material and Methods: A total of 59 toddlers up to 36 months old with at least two primary molar teeth with untreated dental caries of single surface on different sides of the mouth will be selected at the Pediatric Dentistry Clinics of the Faculty of Dentistry at Federal University of Minas Gerais (UFMG), Brazil. Teeth with untreated dental caries in the left and right sides of each patient’s mouth will be randomly distributed into 2 groups: Group 1 (Control): encapsulated RMGIC restoration with Riva light cure (SDI, Florida, USA) and Group 2 (Test): Filtek bulk-fill composite resin restoration (3M/ESPE, St. Paul, USA) with universal single bond adhesive system (3M/ESPE, St. Paul, USA). A single trained dentist will perform all restorative procedures. The restorations will be evaluated after 1, 6, 12, 18 and 24 months by two trained and calibrated examiners. Cost-efficacy analysis will be carried out. Kaplan-Meier survival analysis, Log-rank test, Cox regression, Poisson regression analysis, Mann-Whitney test or Kruskal-Wallis will be performed to analyze data. Conclusion: The protocol will make it possible to determine the most efficacy material for the restoration of cavities in cavities in primary molars of toddlers.Antecedentes: El objetivo de este estudio fue elaborar un protocolo de ensayo clínico aleatorizado para evaluar la efectividad de las restauraciones de clase I en cemento de ionómero de vidrio modificado con resina (RMGIC) y resina bulk-fill en molares primarios con caries de la primera infancia no tratadas en niños preescolares. Material y Métodos: Un total de 59 niños de hasta 36 meses de edad con al menos dos molares temporales con caries no tratada de superficie única en diferentes lados de la boca serán seleccionados en las Clínicas de Odontología Pediátrica de la Facultad de Odontología de la Universidad Federal de Minas Gerais (UFMG), Brasil. Los dientes con caries no tratada en los lados izquierdo y derecho de la boca de cada paciente se distribuirán aleatoriamente en 2 grupos: Grupo 1 (Control): restauración RMGIC encapsulada con fotopolimerización Riva (SDI, Florida, EE. UU.) Y Grupo 2 (Prueba): Restauración de resina compuesta bulk-fill Filtek (3M / ESPE, St. Paul, EE. UU.) con sistema adhesivo de unión simple universal (3M / ESPE, St. Paul, EE. UU.). Un solo dentista capacitado realizará todos los procedimientos de restauración. Las restauraciones serán evaluadas después de 1, 6, 12, 18 y 24 meses por dos examinadores capacitados y calibrados. Se llevará a cabo un análisis de coste-eficacia. Se realizarán análisis de supervivencia de Kaplan-Meier, prueba de rango logarítmico, regresión de Cox, análisis de regresión de Poisson, prueba de Mann-Whitney o Kruskal-Wallis para analizar los datos. Conclusión: El protocolo permitirá determinar el material más eficaz para la restauración de caries en molares temporales de niños preescolares

Search for CPCP violation in D0^0→\to KS0^0_\mathrm{S}KS0^0_\mathrm{S} decays in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceA search is reported for charge-parity D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$$CP$ violation in D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ decays, using data collected in proton-proton collisions at $\sqrt{s}$ = 13 TeV recorded by the CMS experiment in 2018. The analysis uses a dedicated data set that corresponds to an integrated luminosity of 41.6 fb$^{-1}$, which consists of about 10 billion events containing a pair of ẖadrons, nearly all of which decay to charm hadrons. The flavor of the neutral D meson is determined by the pion charge in the reconstructed decays D$^{*+}$$\to$ D$^0\pi^+$ and D$^{*-}$$\to$ D$^0\pi^-$. The D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$$CP$ asymmetry in D$^0$$\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ is measured to be $A_{CP}$( K$^0_\mathrm{S}$K$^0_\mathrm{S}$) = (6.2 $\pm$ 3.0 $\pm$ 0.2 $\pm$ 0.8)%, where the three uncertainties represent the statistical uncertainty, the systematic uncertainty, and the uncertainty in the measurement of the D$^0$ $\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ $CP$ asymmetry in the D$^0$ $\to$ K$^0_\mathrm{S}\pi^+\pi^-$ decay. This is the first D$^0$ $\to$ K$^0_\mathrm{S}$K$^0_\mathrm{S}$ $CP$ asymmetry measurement by CMS in the charm sector as well as the first to utilize a fully hadronic final state

The CMS Statistical Analysis and Combination Tool: COMBINE

International audienceThis paper describes the COMBINE software package used for statistical analyses by the CMS Collaboration. The package, originally designed to perform searches for a Higgs boson and the combined analysis of those searches, has evolved to become the statistical analysis tool presently used in the majority of measurements and searches performed by the CMS Collaboration. It is not specific to the CMS experiment, and this paper is intended to serve as a reference for users outside of the CMS Collaboration, providing an outline of the most salient features and capabilities. Readers are provided with the possibility to run COMBINE and reproduce examples provided in this paper using a publicly available container image. Since the package is constantly evolving to meet the demands of ever-increasing data sets and analysis sophistication, this paper cannot cover all details of COMBINE. However, the online documentation referenced within this paper provides an up-to-date and complete user guide

Dark sector searches with the CMS experiment

Astrophysical observations provide compelling evidence for gravitationally interacting dark matter in the universe that cannot be explained by the standard model of particle physics. The extraordinary amount of data from the CERN LHC presents a unique opportunity to shed light on the nature of dark matter at unprecedented collision energies. This Report comprehensively reviews the most recent searches with the CMS experiment for particles and interactions belonging to a dark sector and for dark-sector mediators. Models with invisible massive particles are probed by searches for signatures of missing transverse momentum recoiling against visible standard model particles. Searches for mediators are also conducted via fully visible final states. The results of these searches are compared with those obtained from direct-detection experiments. Searches for alternative scenarios predicting more complex dark sectors with multiple new particles and new forces are also presented. Many of these models include long-lived particles, which could manifest themselves with striking unconventional signatures with relatively small amounts of background. Searches for such particles are discussed and their impact on dark-sector scenarios is evaluated. Many results and interpretations have been newly obtained for this Report.Astrophysical observations provide compelling evidence for gravitationally interacting dark matter in the universe that cannot be explained by the standard model of particle physics. The extraordinary amount of data from the CERN LHC presents a unique opportunity to shed light on the nature of dark matter at unprecedented collision energies. This Report comprehensively reviews the most recent searches with the CMS experiment for particles and interactions belonging to a dark sector and for dark-sector mediators. Models with invisible massive particles are probed by searches for signatures of missing transverse momentum recoiling against visible standard model particles. Searches for mediators are also conducted via fully visible final states. The results of these searches are compared with those obtained from direct-detection experiments. Searches for alternative scenarios predicting more complex dark sectors with multiple new particles and new forces are also presented. Many of these models include long-lived particles, which could manifest themselves with striking unconventional signatures with relatively small amounts of background. Searches for such particles are discussed and their impact on dark-sector scenarios is evaluated. Many results and interpretations have been newly obtained for this Report

Search for heavy neutral leptons in final states with electrons, muons, and hadronically decaying tau leptons in proton-proton collisions at s\sqrt{s} =13 TeV

International audienceA search for heavy neutral leptons (HNLs) of Majorana or Dirac type using proton-proton collision data at $\sqrt{s}$ =13 TeV is presented. The data were collected by the CMS experiment at the CERN LHC and correspond to an integrated luminosity of 138 fb$^{-1}$. Events with three charged leptons (electrons, muons, and hadronically decaying tau leptons) are selected, corresponding to HNL production in association with a charged lepton and decay of the HNL to two charged leptons and a standard model (SM) neutrino. The search is performed for HNL masses between 10 GeV and 1.5 TeV. No evidence for an HNL signal is observed in data. Upper limits at 95% confidence level are found for the squared coupling strength of the HNL to SM neutrinos, considering exclusive coupling of the HNL to a single SM neutrino generation, for both Majorana and Dirac HNLs. The limits exceed previously achieved experimental constraints for a wide range of HNL masses, and the limits on tau neutrino coupling scenarios with HNL masses above the W boson mass are presented for the first time

Searches for Higgs boson production through decays of heavy resonances

International audienceThe discovery of the Higgs boson has led to new possible signatures for heavy resonance searches at the LHC. Since then, search channels including at least one Higgs boson plus another particle have formed an important part of the program of new physics searches. In this report, the status of these searches by the CMS Collaboration is reviewed. Searches are discussed for resonances decaying to two Higgs bosons, a Higgs and a vector boson, or a Higgs boson and another new resonance, with proton-proton collision data collected at $\sqrt{s}$ = 13 TeV in the years 2016-2018. A combination of the results of these searches is presented together with constraints on different beyond-the-standard model scenarios, including scenarios with extended Higgs sectors, heavy vector bosons and extra dimensions. Studies are shown for the first time by CMS on the validity of the narrow-width approximation in searches for the resonant production of a pair of Higgs bosons. The potential for a discovery at the High Luminosity LHC is also discussed

Overview of high-density QCD studies with the CMS experiment at the LHC

International audienceThe heavy ion (HI) physics program has proven to be an essential part of the overall physics program at the Large Hadron Collider at CERN. Its main purpose has been to provide a detailed characterization of the quark-gluon plasma (QGP), a deconfined state of quarks and gluons created in high-energy nucleus-nucleus collisions. From the start of the LHC HI program with lead-lead collisions, the CMS Collaboration has performed measurements using additional data sets in different center-of-mass energies with xenon-xenon, proton-lead, and proton-proton collisions. A broad collection of observables related to high-density quantum chromodynamics (QCD), precision quantum electrodynamics (QED), and even novel searches of phenomena beyond the standard model (BSM) have been studied. Major advances toward understanding the macroscopic and microscopic QGP properties were achieved at the highest temperature reached in the laboratory and for vanishingly small values of the baryon chemical potential. This article summarizes key QCD, QED, as well as BSM physics, results of the CMS HI program for the LHC Runs 1 (2010-2013) and 2 (2015-2018). It reviews findings on the partonic content of nuclei and properties of the QGP and describes the surprising QGP-like effects in collision systems smaller than lead-lead or xenon-xenon. In addition, it outlines the scientific case of using ultrarelativistic HI collisions in the coming decades to characterize the QGP with unparalleled precision and to probe novel fundamental physics phenomena

Search for the Z boson decay to ττμμ\tau\tau\mu\mu in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceThe first search for the Z boson decay to $\tau\tau\mu\mu$ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb$^{-1}$. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.9 times the standard model expectation is placed on the ratio of the Z $\to$ $\tau\tau\mu\mu$ to Z $\to$ 4$\mu$ branching fractions. Limits are also placed on the six flavor-conserving four-lepton effective-field-theory operators involving two muons and two tau leptons, for the first time testing all such operators