Il lapidario del seminario vescovile di Susa (Torino)

Dopo aver accennato alla formazione storica della collezione, se ne descrivono brevemente allestimento e consistenza documentaria; si propone poi una valorizzazione del lapidario, nel rispetto della sua originale disposizione antiquaria.After mentioning the historical formation of the collection, the article describes its exposition and epigraphical documentation. It is then proponed a valorization of the Lapidary in respect of its original antiquarian placing

Literacy Stories for Global Wits: Learning English Through the Literature-Language Line

This essay addresses the drastic and detrimental divide between language and literature characterizing the study of English in university programs and sustains it is high time for language and literary studies to dovetail a common ground allowing students to better comprehend and navigate through both the complex phenomenon of the spread of English in this era of globalization and the transcultural nature of English itself. One way how this pedagogical turn may be made is exemplified by an English course I taught to English Studies undergraduates at the University of Venice, Italy, in 2014. In examining four literacy stories by J.M Coetzee, Ngugi Wa Thiong'o, Ngozi Chimamanda Adichie and Caryl Phillips, the course had two aims: first, to prove that English, as any language, is formed in relation to personal identity and the context of use with its specific culture, a basic principle often implicitly denied by the widespread  structuralist and generative approaches to language; second, to see the English classroom as a microcosm connected to the social and cultural dynamics of the English-speaking  world at large, by using exceptional stories set in ex-colonial scenarios as mirrors casting reflections of one's positions  and aspirations.

Hoc decreto in domo suo posita (CIL VI, 1492). La tabula esposta in casa del patrono: qualche proposta per una sua identificazione

Le tabulae hospitales et patronatus e le tabulae patronatus sono elementi scrittori, seppur non comuni, pertinenti a un contesto epigrafico domestico d’arredo di ambito sociale medio-alto: si propone un inventario degli indizi utili a individuare quali furono le copie conferite in età imperiale e tardo imperiale ad uso privato dei patroni e quali invece quelle destinate all’esposizione pubblica.Die tabulae hospitales et patronatus und die tabulae patronatus sind Inschriftenträger, die, wenn auch nur selten, zur häuslichen epigraphischen Ausstattung der höheren Mittelschicht gehören. In diesem Aufsatz wird eine Bestandsaufnahme jener Elemente vorgestellt, die dazu beitragen sollen, die Kopien, die in der mittleren und späten Kaiserzeit zur privaten Nutzung der patroni bestimmt waren, von denjenigen, die in der Öffentlichkeit ausgestellt wurden, zu unterscheiden

Ripensare al part time, ripensare il part time? Il lavoro a tempo parziale tra sfide demografiche e crisi economica.

L'Italia negli ultimi anni sta affrontando diverse sfide: in particolare vi sono significative pressioni sui sistemi previdenziale e sanitario a causa dell'invecchiamento della popolazione e del basso tasso di fecondit\ue0, associata all'aumento dei costi delle tecnologie medicali, dell'incidenza delle malattie croniche e alla perpetuante crisi finanziaria. Per questo l'Italia, come molti Stati membri dell'Unione Europea, ha attuato e sta continuando ad implementare riforme per migliorare la sostenibilit\ue0, finanziaria e sociale, dei propri sistemi pensionistici. A fronte delle gi\ue0 importanti pressioni sui conti pubblici, il nostro Legislatore ha risposto con l'aumento dell'et\ue0 pensionabile per entrambi i sessi (soggetta a continui aggiustamenti sulla base dell'aspettativa media di vita) e con l\u2019abolizione del sistema di calcolo c.d. \u2018retributivo\u2019, ad oggi utilizzato per determinare solo delle quote dell\u2019importo dell\u2019assegno previdenziale. Tuttavia, l'obiettivo di scoraggiare il pensionamento anticipato e di aumentare l'et\ue0 pensionabile effettiva presenta delle criticit\ue0: infatti molte persone non riescono a lavorare fino all'et\ue0 pensionabile perch\ue8 sono o fortemente demotivate, o affette da limitazioni fisiche e/o psichiche provocate dalle eterogenee tipologie di malattie croniche. La riduzione dell'orario di lavoro durante gli ultimi anni di attivit\ue0 risulta essere un valido approccio per consentire alle persone di lavorare pi\uf9 a lungo di quanto sarebbe stato possibile se avessero continuato a lavorare a tempo pieno. Certo, un limite di questa politica \ue8 la diminuzione di reddito provocata dalla riduzione delle ore lavorate. Schemi di pensionamento parziale affrontano questa barriera sostituendo una parte della perdita di reddito con un anticipo pensionistico o con dei benefici economici temporanei, entrambe misure finanziariamente molto onerose

Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors

Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia, oxygen/glucose deprivation (OGD), leads to an enhanced permeability of AMPARs to Ca2+, resulting in delayed cell death. However, it is unclear whether the same mechanisms exist in CA3 neurons and whether this underlies the differential sensitivity to ischemia. Here, we investigated the consequences of OGD for AMPAR function in CA3 neurons using electrophysiological recordings in rat hippocampal slices. Following a 15 min OGD protocol, a substantial depression of AMPAR-mediated synaptic transmission was observed at CA3 associational/commissural and mossy fiber synapses but not CA1 Schaffer collateral synapses. The depression of synaptic transmission following OGD was prevented by metabotropic glutamate receptor 1 (mGluR1) or A3 receptor antagonists, indicating a role for both glutamate and adenosine release. Inhibition of PLC, PKC, or chelation of intracellular Ca2+ also prevented the depression of synaptic transmission. Inclusion of peptides to interrupt the interaction between GluA2 and PICK1 or dynamin and amphiphysin prevented the depression of transmission, suggesting a dynamin and PICK1-dependent internalization of AMPARs after OGD. We also show that a reduction in surface and total AMPAR protein levels after OGD was prevented by mGluR1 or A3 receptor antagonists, indicating that AMPARs are degraded following internalization. Thus, we describe a novel mechanism for the removal of AMPARs in CA3 pyramidal neurons following OGD that has the potential to reduce excitotoxicity and promote neuroprotectio

SUMOylation: novel neuroprotective approach for Alzheimer's disease?

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized in the brain by the formation of amyloid-beta (Aβ)-containing plaques and neurofibrillary tangles containing the microtubule-associated protein tau. Neuroinflammation is another feature of AD and astrocytes are receiving increasing attention as key contributors. Although some progress has been made, the molecular mechanisms underlying the pathophysiology of AD remain unclear. Interestingly, some of the main proteins involved in AD, including amyloid precursor protein (APP) and tau, have recently been shown to be SUMOylated. The post-translational modification by SUMO (small ubiquitin-like modifier) has been shown to regulate APP and tau and may modulate other proteins implicated in AD. Here we present an overview of recent studies suggesting that protein SUMOylation might be involved in the underlying pathogenic mechanisms of AD and discuss how this could be exploited for therapeutic intervention

Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model

► Global levels of ubiquitinated proteins increased in the hippocampus of Tg2576 mice. ► No global changes in either SUMO-1 or SUMO-2/3 conjugation in any brain regions analysed. ► SUMO conjugating and deconjugating enzymes, UBC9 and SENP-1, unaltered in Tg2576 mice. ► Total levels of AMPA and kainate receptors were also unaffected in Tg2576 mice. ► Posttranslational modification by ubiquitin may play a role in Alzheimer's disease

Introduction

Introduction to the 3rd number of the journal, entitled "Italy through Postcolonial Eyes". The introduction discusses the articles gathered in this issue that derive from a project on the representation of Italy and its culture in the literature, cinema and theatre of the former British colonies and settler colonies. The two main points at issue both in the essays and in this introduction are the ways in which Italy has been interpreted through the eyes of contemporary postcolonial literature in English, and Italy’s present postcolonial moment. The former has a well-established tradition in Italy, mainly thanks to the pioneering work done by university research groups that have contributed to understand and spread both Anglophone postcolonial literature and its sophisticated, revolutionary theoretical thought from the late 80s to our days. Italy’s present postcolonial moment has been brought into focus more recently, thanks to the convergence the work done by scholars of Italian literature; new trans-disciplinary research that discovers a latent ‘Italian postcolonial paradigm’ in the works of philosophers, writers and literary critics; and a new postcolonial literature produced in Italy that takes into account other postcolonial experiences (in particular in English speaking countries). From this theoretical framework the introduction moves on to the analysis of each of the chapter of this journal's issue

Una aproximación a la concepción de familia en las políticas sociales. Un estudio en América Latina

Fil: Cimarosti, Marta L.. Universidad Nacional Villa María; Argentina..Fil: Musso, María Paola. Universidad Nacional Villa María; Argentina.

An Approach to the Simulation of a Batch-respirometer

Dynamic models in activated sludge processes have demonstrated to be a reliable and useful instrument in design and management of wastewater treatment plants. The biochemical nature of the processes involved the models which need a specific calibration to local conditions. A common method to determine kinetic and stoichiometric parameters of the biomass or wastewater/sludge fractionations is respirometry. Theoretically, nearly all biomass parameters and fractions can be estimated by respirometry, but a lot of difficulties rise when some parameters, such as saturation and hydrolysis rate constants, have to be drawn from experimental data. The aim of our work is the setting up of a simple method to calibrate Activated Sludge Model No. 1 applying traditional batch respirometric tests together with dynamic simulations of the respirometer itself