Synthesis of Benzopyridoindolone Derivatives via a One-Pot Copper Catalyzed Tandem Reaction of 2‑Iodobenzamide Derivatives and 2‑Iodobenzylcyanides

An efficient approach for the synthesis of benzo-fused pyridoindolone derivatives via a one-pot copper catalyzed tandem reaction of 2-iodobenzamides with 2-iodobenzylcyanides has been developed. Using this protocol, benzo-fused pyridoindolone derivatives are obtained in high yields in a relatively short period of time under mild reaction conditions. To the best of our knowledge, this is the first approach where one can synthesize free indole N–H benzo-fused pyridoindolones. Also, both indole and pyridone cores are constructed during the course of the reaction. The methodology shows good functional group tolerance and allows synthesis of thiophene-fused pyridoindolones and fused indolobenzonaphthyridone derivatives

Synthesis of Indolylquinolines, Indolylacridines, and Indolylcyclopenta[<i>b</i>]quinolines from the Baylis–Hillman Adducts: An in Situ [1,3]-Sigmatropic Rearrangement of an Indole Nucleus To Access Indolylacridines and Indolylcyclopenta[<i>b</i>]quinolines

A simple and easy route to the synthesis of a variety of structurally diverse indolylquinolines, indolylacridines, and indolylcyclopenta­[<i>b</i>]­quinoline derivatives via the reductive cyclization of C-alkylated indole derivatives, derived from acyclic as well as cyclic Baylis–Hillman adducts with indoles, is described. An unusual in situ [1,3]-sigmatropic rearrangement of the indole nucleus was observed during the reductive cyclicization of α-regioselective B–H adducts containing indoles to produce indolylacridines and indolylcyclopenta­[<i>b</i>]­quinoline derivatives

Synthesis of Indolylquinolines, Indolylacridines, and Indolylcyclopenta[<i>b</i>]quinolines from the Baylis–Hillman Adducts: An in Situ [1,3]-Sigmatropic Rearrangement of an Indole Nucleus To Access Indolylacridines and Indolylcyclopenta[<i>b</i>]quinolines

A simple and easy route to the synthesis of a variety of structurally diverse indolylquinolines, indolylacridines, and indolylcyclopenta­[<i>b</i>]­quinoline derivatives via the reductive cyclization of C-alkylated indole derivatives, derived from acyclic as well as cyclic Baylis–Hillman adducts with indoles, is described. An unusual in situ [1,3]-sigmatropic rearrangement of the indole nucleus was observed during the reductive cyclicization of α-regioselective B–H adducts containing indoles to produce indolylacridines and indolylcyclopenta­[<i>b</i>]­quinoline derivatives

Synthesis of Indolylquinolines, Indolylacridines, and Indolylcyclopenta[<i>b</i>]quinolines from the Baylis–Hillman Adducts: An in Situ [1,3]-Sigmatropic Rearrangement of an Indole Nucleus To Access Indolylacridines and Indolylcyclopenta[<i>b</i>]quinolines

A simple and easy route to the synthesis of a variety of structurally diverse indolylquinolines, indolylacridines, and indolylcyclopenta­[<i>b</i>]­quinoline derivatives via the reductive cyclization of C-alkylated indole derivatives, derived from acyclic as well as cyclic Baylis–Hillman adducts with indoles, is described. An unusual in situ [1,3]-sigmatropic rearrangement of the indole nucleus was observed during the reductive cyclicization of α-regioselective B–H adducts containing indoles to produce indolylacridines and indolylcyclopenta­[<i>b</i>]­quinoline derivatives

Techniques and methods of assessing projects including inflation

Навчальний посібник виготовлено відповідно до програми з нормативної навчальної дисципліни "Фінансовий менеджмент", яку включено до навчального плану підгтовки освітньо-кваліфікаційного рівня "спеціаліст" і "магістр" спеціальностей. У ньому викладено сутність і завдання фінансового менеджменту, підходи до управління активами, капіталом, інвестиціями, фінансовими ризиками підприємства, основи управління вартістю бізнесу.The book is made in accordance with the program of regulatory discipline "Financial Management", which is included in the educational program for qualification of "expert" and "master" specialties. It outlines the nature and objectives of financial management, approaches to asset management, capital investment, financial risk companies, foundations of business value

Synthesis of Indolylquinolines, Indolylacridines, and Indolylcyclopenta[<i>b</i>]quinolines from the Baylis–Hillman Adducts: An in Situ [1,3]-Sigmatropic Rearrangement of an Indole Nucleus To Access Indolylacridines and Indolylcyclopenta[<i>b</i>]quinolines

A simple and easy route to the synthesis of a variety of structurally diverse indolylquinolines, indolylacridines, and indolylcyclopenta­[<i>b</i>]­quinoline derivatives via the reductive cyclization of C-alkylated indole derivatives, derived from acyclic as well as cyclic Baylis–Hillman adducts with indoles, is described. An unusual in situ [1,3]-sigmatropic rearrangement of the indole nucleus was observed during the reductive cyclicization of α-regioselective B–H adducts containing indoles to produce indolylacridines and indolylcyclopenta­[<i>b</i>]­quinoline derivatives

Synthesis of Indolylquinolines, Indolylacridines, and Indolylcyclopenta[<i>b</i>]quinolines from the Baylis–Hillman Adducts: An in Situ [1,3]-Sigmatropic Rearrangement of an Indole Nucleus To Access Indolylacridines and Indolylcyclopenta[<i>b</i>]quinolines

A simple and easy route to the synthesis of a variety of structurally diverse indolylquinolines, indolylacridines, and indolylcyclopenta­[<i>b</i>]­quinoline derivatives via the reductive cyclization of C-alkylated indole derivatives, derived from acyclic as well as cyclic Baylis–Hillman adducts with indoles, is described. An unusual in situ [1,3]-sigmatropic rearrangement of the indole nucleus was observed during the reductive cyclicization of α-regioselective B–H adducts containing indoles to produce indolylacridines and indolylcyclopenta­[<i>b</i>]­quinoline derivatives

Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction

A concise route for the synthesis of indenoisoquinoline derivatives from 2-iodobenzamide and 1,3-indanedione derivatives in the presence of copper­(II) chloride and cesium carbonate in acetonitrile solvent is reported. A wide variety of 2-iodobenzamide derivatives and indandiones could be used to synthesize indenoisoquinoline derivatives and other fused indenoisoquinoline in moderate to good yields. This methodology was adapted for the one-step synthesis of a series of clinically active topoisomerase I inhibitors such as NSC 314622, LMP-400, LMP-776

Synthesis of Isocoumarin Derivatives via the Copper-Catalyzed Tandem Sequential Cyclization of 2- Halo-<i>N</i>-phenyl Benzamides and Acyclic 1,3-Diketones

A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C–C/C–O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-<i>N</i>-phenyl benzamides and acyclic diketones as starting materials were investigated

Synthesis of Isocoumarin Derivatives via the Copper-Catalyzed Tandem Sequential Cyclization of 2- Halo-<i>N</i>-phenyl Benzamides and Acyclic 1,3-Diketones

A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C–C/C–O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-<i>N</i>-phenyl benzamides and acyclic diketones as starting materials were investigated