4,253 research outputs found
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown. Here we report that oxytocin--a hormone best known for its role in lactation, parturition and social behaviours--is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Inhibition of oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell activation/proliferation through activation of the MAPK/ERK signalling pathway. We further show that the genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. Considering that oxytocin is an FDA-approved drug, this work reveals a potential novel and safe way to combat or prevent skeletal muscle ageing
A quantitative central limit theorem for linear statistics of random matrix eigenvalues
It is known that the fluctuations of suitable linear statistics of Haar
distributed elements of the compact classical groups satisfy a central limit
theorem. We show that if the corresponding test functions are sufficiently
smooth, a rate of convergence of order almost can be obtained using a
quantitative multivariate CLT for traces of powers that was recently proven
using Stein's method of exchangeable pairs.Comment: Title modified; main result stated under slightly weaker conditions;
accepted for publication in the Journal of Theoretical Probabilit
The smallest eigenvalue of Hankel matrices
Let H_N=(s_{n+m}),n,m\le N denote the Hankel matrix of moments of a positive
measure with moments of any order. We study the large N behaviour of the
smallest eigenvalue lambda_N of H_N. It is proved that lambda_N has exponential
decay to zero for any measure with compact support. For general determinate
moment problems the decay to 0 of lambda_N can be arbitrarily slow or
arbitrarily fast. In the indeterminate case, where lambda_N is known to be
bounded below by a positive constant, we prove that the limit of the n'th
smallest eigenvalue of H_N for N tending to infinity tends rapidly to infinity
with n. The special case of the Stieltjes-Wigert polynomials is discussed
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Shear stress regulation of miR-93 and miR-484 maturation through nucleolin.
Pulsatile shear (PS) and oscillatory shear (OS) elicit distinct mechanotransduction signals that maintain endothelial homeostasis or induce endothelial dysfunction, respectively. A subset of microRNAs (miRs) in vascular endothelial cells (ECs) are differentially regulated by PS and OS, but the regulation of the miR processing and its implications in EC biology by shear stress are poorly understood. From a systematic in silico analysis for RNA binding proteins that regulate miR processing, we found that nucleolin (NCL) is a major regulator of miR processing in response to OS and essential for the maturation of miR-93 and miR-484 that target mRNAs encoding Krüppel-like factor 2 (KLF2) and endothelial nitric oxide synthase (eNOS). Additionally, anti-miR-93 and anti-miR-484 restore KLF2 and eNOS expression and NO bioavailability in ECs under OS. Analysis of posttranslational modifications of NCL identified that serine 328 (S328) phosphorylation by AMP-activated protein kinase (AMPK) was a major PS-activated event. AMPK phosphorylation of NCL sequesters it in the nucleus, thereby inhibiting miR-93 and miR-484 processing and their subsequent targeting of KLF2 and eNOS mRNA. Elevated levels of miR-93 and miR-484 were found in sera collected from individuals afflicted with coronary artery disease in two cohorts. These findings provide translational relevance of the AMPK-NCL-miR-93/miR-484 axis in miRNA processing in EC health and coronary artery disease
The BCS Functional for General Pair Interactions
The Bardeen-Cooper-Schrieffer (BCS) functional has recently received renewed
attention as a description of fermionic gases interacting with local pairwise
interactions. We present here a rigorous analysis of the BCS functional for
general pair interaction potentials. For both zero and positive temperature, we
show that the existence of a non-trivial solution of the nonlinear BCS gap
equation is equivalent to the existence of a negative eigenvalue of a certain
linear operator. From this we conclude the existence of a critical temperature
below which the BCS pairing wave function does not vanish identically. For
attractive potentials, we prove that the critical temperature is non-zero and
exponentially small in the strength of the potential.Comment: Revised Version. To appear in Commun. Math. Phys
Graphene transistors are insensitive to pH changes in solution
We observe very small gate-voltage shifts in the transfer characteristic of
as-prepared graphene field-effect transistors (GFETs) when the pH of the buffer
is changed. This observation is in strong contrast to Si-based ion-sensitive
FETs. The low gate-shift of a GFET can be further reduced if the graphene
surface is covered with a hydrophobic fluorobenzene layer. If a thin Al-oxide
layer is applied instead, the opposite happens. This suggests that clean
graphene does not sense the chemical potential of protons. A GFET can therefore
be used as a reference electrode in an aqueous electrolyte. Our finding sheds
light on the large variety of pH-induced gate shifts that have been published
for GFETs in the recent literature
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