1,882 research outputs found
Psychogenic non-epileptic seizures in children and adolescents - a Danish nationwide cohort study
The WHO-5 well-being scale and its correlation to depressive and manic symptoms among outpatients with bipolar disorder or unipolar depression
INTRODUCTION: There is a lack of longitudinal studies of patients with bipolar disorder (BD) or unipolar depression (UD) in terms of psychological well-being as measured by the WHO-5 and the correlation to symptom scores. It is of interest to investigate whether the WHO-5 is useful in monitoring patients with mood disorders over time, as a tool in measurement-based care, and as a supplement to other psychometric measures. OBJECTIVES: In this study we investigate the correlation at baseline between the depressive symptom scores according to the 6-item Hamilton Depression Score (HDS-6) and the WHO-5 scores in outpatients treated for BD or UD. Furthermore, in patients with BD we investigate correlations between manic symptom scores according to the modified Bech-Rafaelsen Mania Scale (MAS-M) and the WHO-5 scores. Lastly, in patients with BD or UD, we investigate the correlations between endpoint-baseline change in WHO-5 and change in MAS-M and HDS-6. METHODS: A longitudinal study of 200 outpatients diagnosed and treated for either BD or UD. Patients will be measured at baseline and at least four weeks later. Baseline data are presented as frequencies, means and standard deviations or medians with interquartile ranges as appropriate. All correlations are presented as scatter plots and a Spearman correlation analysis RESULTS: The study is ongoing, but the results will be available for presentation at the EPA in 2021. CONCLUSIONS: The WHO-5 may represent a relevant outcome measure in the treatment of BD and UD. DISCLOSURE: No significant relationships
Treatment Provided in Children and Adolescents with Functional Seizures-A Danish Nationwide Cohort
Walking a tightrope - as a next-of-kin to an adolescent or young adult with cancer facing eating difficulties
Purpose: Eating difficulties cause reduced food intake and poor quality of life among adolescents and young adults (AYAs) with cancer. Therefore, next-of-kin eating support is crucial. The purpose of this study was to explore the lived experiences of being close to AYAs with cancer in the context of eating when they are at home between high-emetogenic chemotherapy (HEC) sessions. Method: In-depth interviews were conducted with 12 next-of-kin to AYAs (15â29 years old) with oncological or haematological diseases, treated with HEC. Van Manenâs hermeneuticphenomenological approach guided the design. Results: The essential meaning of the next-of-kin experiences is reflected in the overarching theme âUtilizing meals as an action-opportunityâ consisting of two subthemes: âBeing on constant alertâ and âWalking a tightrope to maintain usual everyday life.â Conclusions: Findings revealed that utilizing meals as an action-opportunity towards AYAsâ food intake involved existential feelings including fear of losing their loved ones. Next-of-kin experienced that providing support through and with food was their only avenue of action. However, this sparked feelings of frustration and powerlessness.publishedVersio
Confidence sets for continuous-time rating
This paper addresses the estimation of default probabilities and associated
confidence sets with special focus on rare events. Research on rating transition
data has documented a tendency for recently downgraded issuers to
be at an increased risk of experiencing further downgrades compared to issuers
that have held the same rating for a longer period of time. To capture
this non-Markov effect we introduce a continuous-time hidden Markov chain
model in which downgrades firms enter into a hidden, âexcitedâ state. Using
data from Moodyâs we estimate the parameters of the model, and conclude
that both default probabilities and confidence sets are strongly influenced by
the introduction of hidden excited states
A multi-wave study of organizational justice at work and long-term sickness absence among employees with depressive symptoms
Polymorphisms in NF-kappa B, PXR, LXR, PPAR gamma and risk of inflammatory bowel disease
AIM: To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease (IBD). METHODS: Genotypes of nuclear factor (NF)-kappa B (NFKB1) NF kappa B -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-gamma (PPAR gamma) PPAR gamma Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls. Odds ratio (OR) and 95% CI were estimated by logistic regression models. RESULTS: The PXR A7635G variant, the PPAR gamma Pro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC (OR: 1.31, 95% CI: 1.03-1.66, P = 0.03, OR: 2.30, 95% CI: 1.04-5.08, P = 0.04, and OR: 1.41, 95% CI: 1.00-1.98, P = 0.05, respectively) compared to the corresponding homozygous wild-type genotypes. Among never smokers, PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD (OR: 1.41, 95% CI: 1.05-1.91, P = 0.02, OR: 1.63, 95% CI: 1.21-2.20, P = 0.001, and OR: 2.02, 95% CI: 1.36-2.99, P = 0.0005, respectively) compared to the respective homozygous variant genotypes. PXR A7635G (rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease (OR: 1.34, 95% CI: 1.03-1.75 and OR: 2.49, 95% CI: 1.24-5.03, respectively). CONCLUSION: Common PXR and LXR polymorphisms may contribute to risk of IBD, especially among never smokers. (C) 2011 Baishideng. All rights reserved
The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH
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