Asymptotic analysis of oscillatory integrals via the Newton polyhedra of the phase and the amplitude

The asymptotic behavior at infinity of oscillatory integrals is in detail investigated by using the Newton polyhedra of the phase and the amplitude. We are especially interested in the case that the amplitude has a zero at a critical point of the phase. The properties of poles of local zeta functions, which are closely related to the behavior of oscillatory integrals, are also studied under the associated situation.Comment: 36 page

Quartet consistency count method for reconstructing phylogenetic trees

Among the distance based algorithms in phylogenetic tree reconstruction, the neighbor-joining algorithm has been a widely used and effective method. We propose a new algorithm which counts the number of consistent quartets for cherry picking with tie breaking. We show that the success rate of the new algorithm is almost equal to that of neighbor-joining. This gives an explanation of the qualitative nature of neighbor-joining and that of dissimilarity maps from DNA sequence data. Moreover, the new algorithm always reconstructs correct trees from quartet consistent dissimilarity maps.Comment: 11 pages, 5 figure

Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis

Organelles allow specialized functions within cells to be localized, contained and independently regulated. This separation is oftentimes achieved by selectively permeable membranes, which enable control of molecular transport, signaling between compartments and containment of stress-inducing factors. Here we consider the role of a number of membrane systems within the cell: the plasma membrane, that of the endoplasmic reticulum, and then focusing on the nucleus, depository for chromatin and regulatory centre of the cell. Nuclear pores allow shuttling of ions, metabolites, proteins and mRNA to and from the nucleus. The activity of transcription factors and signaling molecules is also modulated by translocation across the nuclear envelope. Many of these processes require 'active transportation' against a concentration gradient and may be regulated by the nuclear pores, Ran-GTP activity and the nuclear lamina. Cells must respond to a combination of biochemical and physical inputs and we discuss too how mechanical signals are carried from outside the cell into the nucleus through integrins, the cytoskeleton and the 'linker of nucleo- and cyto-skeletal' (LINC) complex which spans the nuclear envelope. Regulation and response to signals and stresses, both internal and external, allow cells to maintain homeostasis within functional tissue

Public libraries and COVID : perceptions and politics in the United States

Public librarians across the U.S. found themselves in different political environments that challenged their ability to serve their communities, to provide the information that was needed, and to fight disinformation regarding the pandemic. Researchers at the University of Missouri examined how and what librarians communicated to the public about COVID. A survey was sent to a systematic sample of libraries from all states and service area sizes, carried out from January 24 to February 7, 2022. A total of 106 responses were received, with 66 respondents having answered every question. Analysis of closed- and open-ended survey responses points to public librarians’ concerns about 1) local government officials and their decisions, 2) resistance on the part of patrons to accurate information, and 3) problems disentangling the local conversation from national media (and social media) perspectives.Joe Kohlburn (University of Missouri, ORCID 0000-0003-2714-826X), Jenny Bossaller (University of Missouri, ORCID 0000-0001-5732-897X), Hyerim Cho (University of Missouri ORCID 0000-0003-2574-3591), Heather Moulaison-Sandy (University of Missouri, ORCID 0000-0001-7783-7069), Denice Adkins (University of Missouri, ORCID 0000-0002-0023-9914)Includes bibliographical references

AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS

While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials. To explore the possibility that concurrent blockade of free radicals and PGE2-mediated inflammation might constitute a safe and effective therapeutic approach to certain neurodegenerative diseases, we have developed 2-hydroxy-5-[2-(4-trifluoromethylphenyl)-ethylaminobezoic acid (AAD-2004) as a derivative of aspirin. AAD-2004 completely removed free radicals at 50 nM as a potent spin trapping molecule and inhibited microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 230 nM. Oral administration of AAD-2004 blocked free radical formation, PGE2 formation, and microglial activation in the spinal motor neurons of SOD1G93A mice. As a consequence, AAD-2004 reduced autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span. In these assays, AAD-2004 was superior to ibuprofen or riluzole. Gastric bleeding was not induced by AAD-2004 even at a dose 400-fold higher than that required to obtain maximal therapeutic efficacy in SOD1G93A mice. Targeting both mPGES-1 and free radicals may be a promising approach to reduce neurodegeneration in ALS and possibly other neurodegenerative diseases

Public libraries and COVID : perceptions and politics in the United States [data]

Files associated with this dataset include: Qualtrics Report on Survey Data Preliminary Data Analysis Spreadsheet Interview Questions Interview Codebook Anonymized Survey Dat

Spatial-temporal Vehicle Re-identification

Vehicle re-identification (ReID) in a large-scale camera network is important in public safety, traffic control, and security. However, due to the appearance ambiguities of vehicle, the previous appearance-based ReID methods often fail to track vehicle across multiple cameras. To overcome the challenge, we propose a spatial-temporal vehicle ReID framework that estimates reliable camera network topology based on the adaptive Parzen window method and optimally combines the appearance and spatial-temporal similarities through the fusion network. Based on the proposed methods, we performed superior performance on the public dataset (VeRi776) by 99.64% of rank-1 accuracy. The experimental results support that utilizing spatial and temporal information for ReID can leverage the accuracy of appearance-based methods and effectively deal with appearance ambiguities.Comment: 10 pages, 6 figure

The Threat to Weather Radars by Wireless Technology

Wireless technology, such as local area telecommunication networks and surveillance cameras, causes severe interference for weather radars because they use the same operational radio frequencies. One or two disturbances can be removed from the radar image, but the number and power of the interfering wireless devices are growing all over the world, threatening that one day the radars could become useless for weather observations. Some agencies have already changed or are considering changing frequency bands, but now even other bands are under threat. Use of equipment at radio frequencies is regulated by laws and international agreements. Technologies have been developed for peaceful coexistence. If wireless devices use these technologies to protect weather radars, their data transmission capabilities become limited, so it is tempting to violate the regulations. Hence, it is an important task for the worldwide weather community to involve themselves in the radio frequency management process and work in close contact with their national radio authorities to ensure that meteorological interests be duly taken into account in any decision-making process toward the future usage of wireless devices.United States. Federal Aviation Administration (FA8721-05-C-0002

Macro Aspects of Housing

This paper aims to achieve two objectives. First, we demonstrate that with respect to business cycle frequency (Burns and Mitchell, 1946), there was a general decrease in the association between macroeconomic variables (MV) and housing market variables (HMV) following the global financial crisis (GFC). However, there are macro-finance variables that exhibited a strong association with the HMV following the GFC. For the medium-term business cycle frequency (Comin and Gertler, 2006), we find that while some correlations exhibit the same change as the business cycle counterparts, others do not. These “new stylized facts” suggest that a reconsideration and refinement of existing “macro-housing” theories would be appropriate. We also provide a review of the recent literature, which may enhance our understanding of the evolving macro-housing-finance linkage

Macro Aspects of Housing

This paper aims to achieve two objectives. First, we demonstrate that with respect to business cycle frequency (Burns and Mitchell, 1946), there was a general decrease in the association between macroeconomic variables (MV) and housing market variables (HMV) following the global financial crisis (GFC). However, there are macro-finance variables that exhibited a strong association with the HMV following the GFC. For the medium-term business cycle frequency (Comin and Gertler, 2006), we find that while some correlations exhibit the same change as the business cycle counterparts, others do not. These “new stylized facts” suggest that a reconsideration and refinement of existing “macro-housing” theories would be appropriate. We also provide a review of the recent literature, which may enhance our understanding of the evolving macro-housing-finance linkage