An examination, planning and control & the management process, to better performance and profitability or: The management process to improve performance for better profitability

Everest and Blanc (E&B) is at a crossroad. It grew from a ‘mom and pop’ operation into a small professional firm and plateaued. Thus, there is a desire to bring about operation efficiency, followed by expansion of the company. In order to be successful, a systematic decision making process is necessary to ensure a high probability of success, and able to pinpoint dysfunctions early for improvement. In addition, implementing processes need careful consideration and progress monitoring. This study was founded on these premises using M2 mode research methodology to establish an optimal structural course of action by surveying paradigms of management theories and concepts. The study began with an exposition on research methodologies and focused on the M2 research mode. It continued on with considering operations topics (micro concerns), extending to general issues (macro concerns) in conjunction with management theories and concepts. Finally a decision making model was shaped and applied to E&B. During the process, several important decisions were made, grounded on the findings on the research, such as relocating the corporate office anticipating expansion. Overall, the changes introduced, the process of change, the decision-making process, and implementation were all effective. The decision making model, SOMM, Strato Operation Management Model, is an extension of both Ansoff’s and Anthony’s management models together with the decision-making process. The emphasis is on the relationship of the system structure’s characteristics where it is symbolized by a matryoshka representing the three management modules (Strategic Management, Management Control and Planning and Tactical Operation) nesting within each other. Relating to the overall strategic and management control and planning competency, the workhorse is a combination of defensive and offensive approaches together with evaluation methodologies to capture emerging and unintended strategies and to control performance; whereas the tactical operation process is to bring about efficiency and effectiveness. These are new knowledge and policies cast into members of E&B. It is, therefore, fundamental that careful interventions are necessary to cause changes by motivation and to align goal congruency. Further, the inquiry had specifically focused on the needs of E&B, it did not preclude application to other organizations. For academics, it may be an engaging topic for further empirical studies advancing knowledge in management and operations. With respect to a wider world application, it was also concluded that the findings for E&B are applicable and adaptable to other professional and business concerns as innovative tools to their problems and issues

Characterization of a Low-Cost Millinewton Force Sensor for Ionic Polymer Metal Composite Actuators

Ionic polymer-metal composites (IPMCs) have become an area of interest in the past decade for their unique properties as actuators. Conventional IPMCs require the use of rare earth metals for electrodes making the fabrication of these materials expensive, time consuming to produce, and not suitable for large scale manufacturing. Due to the low actuational forces, in the millinewton scale, characterization of IPMCs is costly and often requires expensive force sensors and data acquisition (DAQ) systems. This thesis explores the capabilities of a low cost, two dimensional millinewton force sensor fabricated out of nitinol #1 wire and orthogonally mounted strain gauge pairs in half bridge configurations. An Arduino microcontroller based DAQ system and a modular test stand were developed to facilitate calibration of the force sensor and testing of IPMCs. The overall system cost, approximately $200 USD, was able to achieve a force resolution of 0.49 mN. Calibration of the force sensor was accomplished gravimetrically and the data was processed in an Arduino-LabVIEW™ interface. An ionic polymer-carbon composite (IPCC) fabrication concept was also developed that utilizes buckypaper (BP) electrodes, electrospun nanofibrous Nafion mats, and EMI-Tf ionic liquid for hydration. The IPCC concept has the potential to achieve faster actuation rates, larger deflections, and longer operations in air compared to IPMCs. The IPCC fabrication process developed takes a fraction of the time compared to conventional IPMC fabrication and can be applied to IPMC fabrication for production on an industrial scale

Cow Brain Glutaminase: Purification, Characterization, and Mechanism of Action

A simple, quick, and sensitive radiometric assay for glutaminase has been established. This assay uses L-(U-14C)-glutamine as the substrate and measures the 14co2 produced when the reaction is coupled to glutamate decarboxylase. An efficient purification procedure for cow brain glutaminase has also been developed; the yield is 12%. Steps include acetone extraction, ammonium sulfate fractionation, calcium phosphate gel treatment, and differential gel filtration on Sepharose 4B. The final preparation has a specific activity of 385 Mmole/min/mg and shows a single protein band on polyacrylamide gel electrophoresis in sodium dodecyl sulfate; this band corresponds to a subunit molecular weight of 82,000. Polyacrylamide gel electrophoresis studies did not reveal any impurities; the enzyme activity coincided with the protein staining. This enzyme is stable between pH 7.5 and 9.2 and has maximal activity around 8.8. The activity of glutaminase appears to be independent of the nature of the buffer with which it was equilibrated before it was assayed. The enzyme absolutely requires phosphate for activity; the dependence is sigmoidal and has a Hill coefficient of 2.2. The phosphate concentration that gives half maximal velocity is 50 mM. At 0.2 M potassium phosphate (pH 8.8), the dependence of activity on glutamine is hyperbolic; the observed Kgln is 17 mM. Neither amnonium ion (0.1 M) nor citrate, succinate, or glutarate (57 mM) inhibit the enzyme activity. Glutamate inhibits competitively with respect to glutamine. Phosphate affects both Kgln and Kglu the same way. A radioactivity exchange study was not able to detect incorporation of 14C-glutamate into 14 c-glutamine. The results are consistent with a model in which ammonia is released irreversibly from the enzyme-substrate complex and is the first product to be released

LIBRARIES IN CHINA

【Abstract】 Education in China can be traced to the remote past, but the new era in Chinese education only began in 1905, when an imperial edict was issued, abolishing the ancient system of classical examinations and replacing it with a modern school system. From 1905 to 1911, several edicts were issued from the Throne, a number of regulations were promulgated by the Ministry of Education, and important educational conferences were held; all of which resulted in improvement towards a democratic educational system. Thousands of new schools were established and many provincial libraries were started

Toxicity of Carbon Nanotubes and its Implications for Occupational and Environmental Health

This viewgraph document reviews the sources of Nano particles in the environment, the structure and properties of Carbon Nanotubes (CNTs), the physical characteristics of CNT materials, pulmonary and other health concerns of exposure to CNTs. The toxicity of CNT in rodents is summarized and some natural, and man-made sources of CNTs are shown. CNTs are electrically and thermally conductive, fibrous, biopersistent and very complicated in structures. The factors affecting toxicity of CNTs are more than size and surface area

Analysis Tools for Discovering Strong Parity Violation at Hadron Colliders

Several arguments suggest parity violation may be observable in high energy strong interactions. We introduce new analysis tools for describing the azimuthal dependence of multi-particle distributions, or "azimuthal flow." Analysis uses the representations of the orthogonal group O(2) and dihedral groups $D_{N}$ necessary to define parity correctly in two dimensions. Classification finds that collective angles used in event-by-event statistics represent inequivalent tensor observables that cannot generally be represented by a single "reaction plane". Many new parity-violating observables exist that have never been measured, while many new parity-conserving observables formerly lumped together are now distinguished. We use the concept of "event shape sorting" to suggest separating right- and left-handed events, and we discuss the effects of transverse and longitudinal spin. The analysis tools are statistically robust, and can be applied equally to low or high multiplicity events at the Tevatron, $RHIC$ or $RHIC\, Spin$, and the $LHC$.Comment: 18 pages, 2 figures. Final version, accepted for publication in PRD. Updated references. Modified presentation and discussion of previous wor

Pulmonary Toxicity Studies of Lunar Dust in Rodents

NASA has been contemplating returning astronauts to the moon for long-duration habitation and research and using it as a stepping-stone to Mars. Other spacefaring nations are planning to send humans to the moon for the first time. The surface of the moon is covered by a layer of fine dust. Fine terrestrial dusts, if inhaled, are known to pose a health risk to humans. Some Apollo crews briefly exposed to moon dust that adhered to spacesuits and became airborne in the Lunar Module reported eye and throat irritation. The habitable area of any lunar landing vehicle or outpost would inevitably become contaminated with lunar dust. To assess the health risks of exposure of humans to airborne lunar dust, we evaluated the toxicity of Apollo 14 moon dust in animal lungs. Studies of the pulmonary toxicity of a dust are generally first done by intratracheal instillation (ITI) of aqueous suspensions of the test dust into the lungs of rodents. If a test dust is irritating or cytotoxic to the lungs, the alveolar macrophages, after phagocytizing the dust particles, will release cellular messengers to recruit white blood cells (WBCs) and to induce dilation of blood capillary walls to make them porous, allowing the WBCs to gain access to the alveolar space. The dilation of capillary walls also allows serum proteins and water entering the lung. Besides altering capillary integrity, a toxic dust can also directly kill the cells that come into contact with it or ingest it, after which the dead cells would release their contents, including lactate dehydrogenase (a common enzyme marker of cell death or tissue damage). In the treated animals, we lavaged the lungs 1 and 4 weeks after the dust instillation and measured the concentrations of these biomarkers of toxicity in the bronchioalveolar lavage fluids to determine the toxicity of the dust. To assess whether the inflammation and cellular injury observed in the biomarker study would lead to persistent or progressive histopathological changes, a similar study was conducted to microscopically examine rat lung tissue and the associated lymph nodes for lesions, including fibrosis, 1 or 3 months after the instillation. The results from this ITI study led us to select two concentrations (20 and 60 mg/cu m) for an inhalation study, in which rats were exposed to lunar dust 6 h daily for 4 weeks (5d/wk). Similar biochemical and histopathological assessments were carried out in these rats 1 day or 1, 4, or 13 weeks after the dust exposure. Rats exposed to lunar dust by ITI or inhalation showed effects indicating that the dust is moderately toxic. The data will be useful to establish safe exposure limits for astronauts working in a lunar habitat and also help engineers designing dust mitigation systems for lunar vehicles and habitats