若年女性の生活習慣と脂質代謝の関連に関する検討

The purpose of this study is to review the factors influencing lipid metabolism of young women in terms of both exercise and nutrition. From the side of nutrition，we reviewed how lipid metabolism is influenced by taking a commercial fish oil supplement（LIQUAMEN）. Total cholesterol deteriorated significantly by taking LIQUAMEN. Improvement of lipid metabolism by LIQUAMEN was suggested. The value of HDL-cholesterol，adiponectin，and leptin were significantly lower in the group of living activity strength Ⅱ while the values of TG and TNF-α increased significantly. This result suggested the possibility that lipid metabolism deteriorated in subjects whose activity was below a certain amount. It also suggested the possibility that lipid metabolism improved in those whose activity was above a certain amount. In the body fat-to-weight ratio， the living activity strengthⅢ・ Ⅳ group showed a significantly lower tendency compared to the group of living activity strength Ⅱ and the group of living activity strengthⅢ・ Ⅳ . This finding suggested that if activity was greater than a certain amount，the body fat-to-weight ratio tended to be comparatively low

Differential expression and the anti-apoptotic effect of human placental neurotrophins and their receptors.

Neurotrophin (NT) is important in the survival, maintenance and differentiation of neuronal tissue, and functions in follicle maturation, tumor growth, angiogenesis and immunomodulation; however, the expression of NT and its receptors (NTR) in human placenta and their influence on fetal growth are unclear. Here we investigated the correlation of NT and NTR in human placenta with uterine environment and fetal growth. TrkB, a NTR, mRNA was expressed on decidual and villous tissue and increased with gestational age, localizing in the trophoblast layer and endothelium by immunohistochemistry. Villous TrkB mRNA was significantly increased in preeclampsia (PE) than in controls and was higher in the normotensive small for gestational age (SGA) placenta, although it was not significant. It was also significantly increased in the small twin of discordant twin pregnancies. Brain-derived neurotrophic factor (BDNF), the main ligand of TrkB, was expressed in membranous chorion and villous tissue and was significantly higher in maternal plasma in normotensive SGA and PE than in controls. TrkB mRNA expression was up-regulated on cultured villous tissue explants and on JEG-3, a choriocarcinoma cell line, by H(2)O(2) treatment. BDNF decreased apoptotic cells in H(2)O(2)-treated JEG-3, indicating that BDNF/TrkB signaling had anti-apoptotic effects against oxidative stress in JEG-3, suggesting a protective role of BDNF/TrkB in human villous tissue under unfavorable conditions in utero