4 research outputs found
In Situ Generation of Phosphoryl Alkylindiums and Their Synthetic Application to Arylalkyl Phosphonates via Palladium-Catalyzed Cross-Coupling Reactions
Phosphoryl
alkylindium reagents are generated in situ from the
direct insertion of indium with bromoalkyl phosphonates in the presence
of CuCl, and their synthetic application to arylalkyl phosphonates
is reported via a Pd-catalyzed cross-coupling reaction with tolerance
of a diversity of functional groups including ester, ketone, aldehyde,
nitrile, nitro, trifluoromethyl, chloride, methoxy, hydroxy, and amino
Synthesis of 2‑Alkoxyaryl-2-aryl Enamines via Tandem Copper-Catalyzed Cycloaddition and Rhodium-Catalyzed Alkoxyarylation from Alkynes, <i>N</i>‑Sulfonyl Azides, and Aryl Ethers
A synthetic route
to a wide range of 2-alkoxyaryl-2-aryl enamines
is developed from Rh-catalyzed alkoxyarylation of <i>N</i>-sulfonyl-4-aryl-1,2,3-triazoles with aryl ethers via the elimination
of nitrogen molecule. In addition, 2-alkoxyaryl-2-aryl enamines are
prepared via tandem Cu-catalyzed cycloaddition and Rh-catalyzed alkoxyarylation
starting from alkynes, <i>N</i>-sulfonyl azides, and aryl
ethers in one-pot
Alkenylation of Phosphacoumarins via Aerobic Oxidative Heck Reactions and Their Synthetic Application to Fluorescent BenzoÂphosphaÂcoumarins
Alkenylation of phosphacoumarins
is developed from the reaction
of phosphacoumarins with a variety of activated as well as nonactivated
alkenes via aerobic oxidative Heck reactions. In addition, 3-alkenylÂphosphaÂcoumarins
undergo an inverse electron demand Diels–Alder reaction (IEDDA)
with enamines <i>in situ</i> generated from ketone and pyrrolidine
followed by 1,2-elimination and a dehydrogenation, producing fluorescent
benzoÂphosphaÂcoumarins
ICl-Mediated Intramolecular Twofold Iodoarylation of Diynes and Diynyl Diethers and Amines: Synthesis of Bis(2<i>H</i>‑hydronaphthalene and chromene) and 2<i>H</i>‑Quinoline Bearing an Alkenyl Iodide Moiety
Electrophilic intramolecular twofold
iodoarylation was developed
from the reaction of diynes and diynyl diethers and amines with iodine
monochloride under mild conditions, which produced bisÂ(2<i>H</i>-hydronaphthalene and chromene) and 2<i>H</i>-quinoline
bearing an alkenyl iodide moiety in good to excellent yields. These
compounds underwent Pd-catalyzed cross-coupling reactions with arylboronic
acid and indium trisÂ(arylthiolate) to produce the functionalized styrene
derivatives