Synthesis of 2‑Alkoxyaryl-2-aryl
Enamines via
Tandem Copper-Catalyzed Cycloaddition and Rhodium-Catalyzed Alkoxyarylation
from Alkynes, <i>N</i>‑Sulfonyl Azides, and Aryl
Ethers
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Abstract
A synthetic route
to a wide range of 2-alkoxyaryl-2-aryl enamines
is developed from Rh-catalyzed alkoxyarylation of <i>N</i>-sulfonyl-4-aryl-1,2,3-triazoles with aryl ethers via the elimination
of nitrogen molecule. In addition, 2-alkoxyaryl-2-aryl enamines are
prepared via tandem Cu-catalyzed cycloaddition and Rh-catalyzed alkoxyarylation
starting from alkynes, <i>N</i>-sulfonyl azides, and aryl
ethers in one-pot