Multiobjective economic MPC of constrained non‐linear systems

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/166264/1/cth2bf00058.pd

MCAD: Multi-teacher Cross-modal Alignment Distillation for efficient image-text retrieval

With the success of large-scale visual-language pretraining models and the wide application of image-text retrieval in industry areas, reducing the model size and streamlining their terminal-device deployment have become urgently necessary. The mainstream model structures for image-text retrieval are single-stream and dual-stream, both aiming to close the semantic gap between visual and textual modalities. Dual-stream models excel at offline indexing and fast inference, while single-stream models achieve more accurate cross-model alignment by employing adequate feature fusion. We propose a multi-teacher cross-modality alignment distillation (MCAD) technique to integrate the advantages of single-stream and dual-stream models. By incorporating the fused single-stream features into the image and text features of the dual-stream model, we formulate new modified teacher features and logits. Then, we conduct both logit and feature distillation to boost the capability of the student dual-stream model, achieving high retrieval performance without increasing inference complexity. Extensive experiments demonstrate the remarkable performance and high efficiency of MCAD on image-text retrieval tasks. Furthermore, we implement a mobile CLIP model on Snapdragon clips with only 93M running memory and 30ms search latency, without apparent performance degradation of the original large CLIP

Treatment responses in adult depressive patients treated with dexamethasone/corticotrophin-releasing hormone

Purpose: To study the dexamethasone/corticotrophin releasing hormones (DEX/CRH) in depressed and healthy patients and to analyse the occurrence of relapse connected to hormonal dysregulation.Methods: A total of 117 depressive patients between 20 and 70 years of age were included in the study group and 40 healthy patients between 25 and 60 years of age in the control group. Group I consisted of 59 patients who received sertraline 50 - 100 mg/day for 5 weeks along with a low dose of 30 mg T3. Group II included 58 patients who received dexamethasone 1 mg orally for 5 weeks. DEX/CRH levels were analyzed. Adrenocorticotrophic hormone and cortisol levels in the blood were analysed by immuno-radiometric assay. Cortisol levels were also analysed by kinetic assay method.Results: In group I, among the 59 patients that received sertraline 50-100 mg/day for 5 weeks with a low dose of 30 mg T3, relapse was observed in 12 (20.3 %) of them. The area under the curve (AUC) was 13.9 ± 6.4 ng.min.1000/mL, which was higher than that for healthy individuals (3.8 ± 3.6 ng.min.1000/mL). Group I patients with relapse showed an adrenocorticotrophic hormone AUC of 16.9 ± 2.4 ng.min.1000/mL, while group II patients exhibited AUC of 13.9 ± 6.4 ng.min.1000/mL.Conclusion: The results emphasizes the need to test hormonal responses to different types of antidepressants.Keywords: stress, depressive patients, hormonal response, hormonal dysregulation, sertraline, dexamethasone, corticotrophin releasing hormon

Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin

Background/Aims: The present study was aimed at examining Ezrin expression in human colorectal cancer (CRC) tissues and elucidating the influence of baicalein on the proliferation of HCT116 cells. Methods: The expression of Ezrin was determined by qRT-PCR and immunohistochemistry. HCT116 cells were divided into four groups－ baicalein groups with various concentrations, pcDNA3.1-Ezrin group, si-Ezrin group and dual inhibitory group (baicalein + si-Ezrin). CCK-8 assay and flow cytometry (FCM) were employed to assess cell proliferation and to detect the distribution of cell cycle respectively. The expression levels of Ezrin protein and cell cycle-associated proteins were detected by using western blot. The proliferation ability of CRC cells was also evaluated in vivo. Results: Ezrin expression in CRC tissues was observably higher than that in adjacent colorectal tissues. With drug concentration and action time of baicalein increasing, the cell propagation capacity of HCT116 cells was decreased and the cell cycle progression was arrested. Ezrin expression was inhibited by the administration of baicalein in a dose-dependent way. The levels of CyclinD1 and CDK4 were also significantly decreased, but the expression of P53 pathway proteins P53 and P21 was markedly upregulated. Conclusion: Baicalein repressed proliferation of human colorectal cancer cells HCT116 and blocked cell cycle through downregulating Ezrin and upregulating P53 pathway-related proteins