Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations.

The physiological asymmetry between daughters of a mother bacterium is produced by the inheritance of either old poles, carrying non-genetic damage, or newly synthesized poles. However, as bacteria display long-term growth stability leading to physiological immortality, there is controversy on whether asymmetry corresponds to aging. Here we show that deterministic age structure landscapes emerge from physiologically immortal bacterial lineages. Through single-cell microscopy and microfluidic techniques, we demonstrate that aging and rejuvenating bacterial lineages reach two distinct states of growth equilibria. These equilibria display stabilizing properties, which we quantified according to the compensatory trajectories of continuous lineages throughout generations. Finally, we show that the physiological asymmetry between aging and rejuvenating lineages produces complex age structure landscapes, resulting in a deterministic phenotypic heterogeneity that is neither an artifact of starvation nor a product of extrinsic damage. These findings indicate that physiological immortality and cellular aging can both be manifested in single celled organisms

Arrival first queueing networks with applications in kanban production systems

In this paper we introduce a new class of queueing networks called {\it arrival first networks}. We characterise its transition rates and derive the relationship between arrival rules, linear partial balance equations, and product form stationary distributions. This model is motivated by production systems operating under a kanban protocol. In contrast with the conventional {\em departure first networks}, where a transition is initiated by service completion of items at the originating nodes that are subsequently routed to the destination nodes (push system), in an arrival first network a transition is initiated by the destination nodes of the items and subsequently those items are processed at and removed from the originating nodes (pull system). These are similar to the push and pull systems in manufacturing systems

Transformation of \u3cem\u3eTetrahymena thermophila\u3c/em\u3e with Hypermethylated rRNA Genes

The extrachromosomal rRNA genes (rDNA) of Tetrahymena thermophila contain 0.4% N6-methyladenine. C3 strain rDNA was isolated, hypermethylated in vitro, and microinjected into B strain host cells. Clonal cell lines were established, and transformants were selected on the basis of resistance to paromomycin, conferred by the injected rDNA. The effects of methylation by three enzymes which methylate the sequence 5\u27-NAT-3\u27, the dam, EcoRI, and ClaI methylases, were tested. Hypermethylation of the injected rDNA had no effect on transformation efficiency relative to mock-methylated controls. The injected C3 strain rDNA efficiently replaced host rDNA as the major constituent of the population of rDNA molecules. Hypermethylation of the injected DNA was not maintained through 20 to 25 cell generations

Reply to Comment on "Chiral suppression of scalar glueball decay"

Reply to the comment of Chao, He, and Ma

Decays of the Meson BcB_c to a PP-Wave Charmonium State χc\chi_c or hch_c

The semileptonic decays, $B_{c}{\longrightarrow}{\chi_c}(h_c)+{\ell}+{{\nu}}_{\ell}$, and the two-body nonleptonic decays, $B_{c}{\longrightarrow}{\chi_c}(h_c)+h$, (here $\chi_c$ and $h_c$ denote $(c\bar c[^3P_J])$ and $(c\bar c[^1P_1])$ respectively, and $h$ indicates a meson) were computed. All of the form factors appearing in the relevant weak-current matrix elements with $B_c$ as its initial state and a $P$-wave charmonium state as its final state for the decays were precisely formulated in terms of two independent overlapping-integrations of the wave-functions of $B_c$ and the $P$-wave charmonium and with proper kinematics factors being `accompanied'. We found that the decays are quite sizable, so they may be accessible in Run-II at Tevatron and in the foreseen future at LHC, particularly, when BTeV and LHCB, the special detectors for B-physics, are borne in mind. In addition, we also pointed out that the decays $B_c\to h_c+...$ may potentially be used as a fresh window to look for the $h_c$ charmonium state, and the cascade decays, $B_c\to \chi_c[^3P_{1,2}]+l+\nu_l$ ($B_c\to \chi_c[^3P_{1,2}]+h$) with one of the radiative decays $\chi_c[^3P_{1,2}] \to J/\psi+\gamma$ being followed accordingly, may affect the observations of $B_c$ meson through the decays $B_{c}\to {J/\psi}+{l}+\nu_{l}$ ($B_c\to J/\psi+h$) substantially.Comment: 24 pages, 3 figures, the replacement for improving the presentation and adding reference

Hadronic production of the PP-wave excited BcB_c-states (BcJ,L=1∗B_{cJ,L=1}^*)

Adopting the complete $\alpha_s^4$ approach of the perturbative QCD (pQCD) and updated parton distribution functions, we have estimated the hadronic production of $P$-wave excited $B_c$-states ($B_{cJ,L=1}^*$). In the estimate, special care on the relation of the production amplitude to the derivative of wave function at origin of the potential model is payed. For experimental references, main uncertainties are discussed, and the total cross sections and the distributions of the production with reasonable cuts at the energies of Tevatron and LHC are computed and presented. The results show that $P$-wave production may contribute to the $B_c$-meson production indirectly by a factor about 0.5 of the direct production, and with such a big cross section, it is worth further to study the possibility to observe the $P$-wave production itself experimentally.Comment: 23 pages, 9 figures, to replace for revising the misprints ec

Multiquark Hadrons

A number of candidate multiquark hadrons, i.e., particle resonances with substructures that are more complex than the quark-antiquark mesons and three-quark baryons that are prescribed in the textbooks, have recently been observed. In this talk I present: some recent preliminary BESIII results on the near-threshold behavior of sigma(e+e- --> Lambda Lambda-bar) that may or may not be related to multiquark mesons in the light- and strange-quark sectors; results from Belle and LHCb on the electrically charged, charmoniumlike Z(4430)^+ --> pi^+ psi ' resonance that necessarily has a four-quark substructure; and the recent LHCb discovery of the P_c(4380) and P_c(4450) hidden-charm resonances seen as a complex structure in the J/psi p invariant mass distribution for Lambda_b --> K^-J/psi p decays and necessarily have a five-quark substructure and are, therefore, prominent candidates for pentaquark baryons.Comment: 12 pages, 9 figures, summary of a talk presented at the 12th Conference on Hypernuclear and Strange Particle Physics (HYP2015), September 7-12, 2015 Sendai, JAPAN. To appear in the JPS Conference proceeding

Avalanche to streamer transition in particle simulations

The avalanche to streamer transition is studied and illustrated in a particle model. The results are similar to those of fluid models. However, when super-particles are introduced, numerical artefacts become visible. This underscores the need of models that are hybrid in space.Comment: 2 pages, 1 figur

The meson BcB_c annihilation to leptons and inclusive light hadrons

The annihilation of the $B_c$ meson to leptons and inclusive light hadrons is analyzed in the framework of nonrelativistic QCD (NRQCD) factorization. We find that the decay mode, which escapes from the helicity suppression, contributes a sizable fraction width. According to the analysis, the branching ratio due to the contribution from the color-singlet component of the meson $B_c$ can be of order (10^{-2}). We also estimate the contributions from the color-octet components. With the velocity scaling rule of NRQCD, we find that the color-octet contributions are sizable too, especially, in certain phase space of the annihilation they are greater than (or comparative to) the color-singlet component. A few observables relevant to the spectrum of charged lepton are suggested, that may be used as measurements on the color-octet and color-singlet components in the future $B_c$ experiments. A typical long distance contribution in the annihilation is estimated too.Comment: 26 pages, 5 figures (6 eps-files), submitted to Phys. Rev.