meningitis

Background: Acinetobacter baumannii is a major cause of nosocomial infections in many hospitals and appears to have a propensity for developing multiple antimicrobial resistance rapidly.Cases: We report two cases with post-surgical meningitis due to multidrug resistant A. baumannii which were successfully treated with high-dose intravenous meropenem therapy.Conclusions: Multidrug resistant Acinetobacter spp. in intensive care units are a growing concern. High-dose meropenem is used in the treatment of these infections

Successful treatment of multidrug resistant Acinetobacter baumannii meningitis.

BACKGROUND: Acinetobacter baumannii is a major cause of nosocomial infections in many hospitals and appears to have a propensity for developing multiple antimicrobial resistance rapidly. CASES: We report two cases with post-surgical meningitis due to multidrug resistant A. baumannii which were successfully treated with high-dose intravenous meropenem therapy. CONCLUSIONS: Multidrug resistant Acinetobacter spp. in intensive care units are a growing concern. High-dose meropenem is used in the treatment of these infections

THE ALTERATION OF THE ANTIBIOTIC SENSITIVITY OF PSEUDOMONAS AERUGINOSA

Objective: Antibiotic resistance is an important problem for the treatment of P aeruginosa infections. The aim of this study is to determine the alteration of the infection rates and antibiotic sensitivity of hospital-acquired P. auruginosa strains throughout the years and to evaluate the empirical treatment options.Material and Method: This study was performed in all patients hospitalized between 2004 and 2006. The antibiotic sensitivity of P aeruginosa isolated by classical methods was determined according to the criteria of the Clinical and Laboratory Standards Institute.Results: In the study period, 228 P aeruginosa strains were evaluated. The hospital infection rate of P aeruginosa was found to be 0.3%, 0.9% and 0.9% among the years of 2004, 2005 and 2006, respectively Amikacin was found the most sensitive aminoglycoside, and beta-lactam antibiotic sensitivity decreased between the years. Multidrug resistance for P aeruginosa was increased from 9.3% to 15.3%.Conclusions: We suggest that amikacin, piperacillin-tazobactam and imipenem should be the first antibiotics choices for empirical treatment of pseudomonas infections due to the fact, multidrug resistance is a increasing by years and can be eliminated by the restriction of inappropriate antibiotic treatment

THE ALTERATION OF THE ANTIBIOTIC SENSITIVITY OF PSEUDOMONAS AERUGINOSA

Objective: Antibiotic resistance is an important problem for the treatment of P aeruginosa infections. The aim of this study is to determine the alteration of the infection rates and antibiotic sensitivity of hospital-acquired P. auruginosa strains throughout the years and to evaluate the empirical treatment options.Material and Method: This study was performed in all patients hospitalized between 2004 and 2006. The antibiotic sensitivity of P aeruginosa isolated by classical methods was determined according to the criteria of the Clinical and Laboratory Standards Institute.Results: In the study period, 228 P aeruginosa strains were evaluated. The hospital infection rate of P aeruginosa was found to be 0.3%, 0.9% and 0.9% among the years of 2004, 2005 and 2006, respectively Amikacin was found the most sensitive aminoglycoside, and beta-lactam antibiotic sensitivity decreased between the years. Multidrug resistance for P aeruginosa was increased from 9.3% to 15.3%.Conclusions: We suggest that amikacin, piperacillin-tazobactam and imipenem should be the first antibiotics choices for empirical treatment of pseudomonas infections due to the fact, multidrug resistance is a increasing by years and can be eliminated by the restriction of inappropriate antibiotic treatment