Objective: Antibiotic resistance is an important problem for the treatment of P aeruginosa infections. The aim of this study is to determine the alteration of the infection rates and antibiotic sensitivity of hospital-acquired P. auruginosa strains throughout the years and to evaluate the empirical treatment options.Material and Method: This study was performed in all patients hospitalized between 2004 and 2006. The antibiotic sensitivity of P aeruginosa isolated by classical methods was determined according to the criteria of the Clinical and Laboratory Standards Institute.Results: In the study period, 228 P aeruginosa strains were evaluated. The hospital infection rate of P aeruginosa was found to be 0.3%, 0.9% and 0.9% among the years of 2004, 2005 and 2006, respectively Amikacin was found the most sensitive aminoglycoside, and beta-lactam antibiotic sensitivity decreased between the years. Multidrug resistance for P aeruginosa was increased from 9.3% to 15.3%.Conclusions: We suggest that amikacin, piperacillin-tazobactam and imipenem should be the first antibiotics choices for empirical treatment of pseudomonas infections due to the fact, multidrug resistance is a increasing by years and can be eliminated by the restriction of inappropriate antibiotic treatment
