Bird radar data_Lund_J Anim Ecol paper_for Dryad

Flight data from individual radar-tracked nocturnal passerines (songbirds) migrating over southern Sweden

Moth radar data_UK_J Anim Ecol paper_for Dryad

Flight data for individual radar-tracked nocturnal noctuid moths Autographa gamma migrating over southern U

height

Mean migration traffic rate (MTR) over two different time periods (entire sampling period: 1 sep-31 oct 2015 and period of MR deployment: 5 – 16 oct 2015) divided into 200 m altitude bins

mtr_gs_track

Mean migration traffic rate (MTR), ground speed (GS) and track direction (track) per night during the campaign. Data is divided in “low” 200-800m and “high” 800-1400m altitude groups

Identification and in Vivo and in Vitro Characterization of Long Acting and Melanocortin 4 Receptor (MC4-R) Selective α-Melanocyte-Stimulating Hormone (α-MSH) Analogues

We report in vitro and in vivo data of new α-melanocyte-stimulating hormone (α-MSH) analogues which are N-terminal modified with a long chain fatty acid derivative. While keeping the pharmacophoric motif (d-Phe-Arg-Trp) fixed, we tried to improve selectivity and physicochemical parameters like solubility and stability of these analogues by replacing amino acids further away from the motif. Receptor specific changes in binding affinity to the melanocortin receptors were observed between the acetyl derivatives and the fatty acid analogues. Furthermore, amino acids at the N-terminal of α-MSH (Ser-Tyr-Ser) not considered to be part of the pharmacophore were found to have an influence on the MC4/MC1 receptor selectivity. While the acetyl analogues have an in vivo effect for around 7 h, the long chain fatty acid analogues have an effect up to 48 h in an acute feeding study in male Sprague–Dawley rats after a single subcutaneous administration