New firm performance and territorial driving forces.

We study post entry performance of manufactuirng firms in 3 municipalities of Buenos Aires province, borned between 1990 and 1999. The aim of the paper is to identify main factors explaining firm growth. The focus is directed to endogenous determinants of firm performance, individual or local as well, taking into account the growing interest those elements are receiving in recent literature about local development. The results show that firm tradability grade is the key variable explaining performance. This factor is strongly influenced by entrepreneur´s profile but also by macroeconomic context.local development, new firms, firm performance, tradability

Isolation and characterization of Campylobacter spp. in meat products

Il progetto di dottorato si è incentrato sull'isolamento e caratterizzazione genomica di Campylobacter spp., che risulta dai report EFSA2019 (Autorità Europea per la Sicurezza Alimentare) la prima causa di zoonosi in Europa. Inoltre, dati in letteratura riferiscono un elevato aumento del fenomeno di antibiotico resistenza e suggeriscono nuovi studi per la valutazione della MDR(MultyDrugResistence). Sono state considerate le due specie più diffuse negli alimenti, Campylobacter jejuni e Campylobacter coli, e sono stati isolati nuovi ceppi da prodotti carnei, pollo e suino, in quanto risultano le principali sorgenti di infezioni. I 25 nuovi isolati sono stati studiati fenotipicamente e genotipicamente, utilizzando come riferimenti, quelli dettati dalle normative vigenti. Si è effettuato il sequenziamento del genoma ed è stata valutata la presenza di geni che conferiscono resistenza ad antibiotici ed aumentano la virulenza. Alcuni dei risultati ottenuti evidenziano che la risposta fenotipica relativa alla resistenza verso alcune molecole antibiotiche, non è sempre attribuibile alla presenza dei singoli geni, ma confermano i dati in letteratura, che mostrano l'importanza dello studio di nuovi meccanismi intrinseci alla cellula batterica, quali ad esempio il sistema delle pompe di efflusso, capaci di conferire una multi-farmaco resistenza. Nella seconda parte dello studio è stata effettuata un analisi di genomica comparativa, includendo oltre ai nuovi isolati, anche 3052 genomi presenti in banche dati pubbliche (1074 C. coli e 1978 C. jejuni),evidenziando la presenza di un adattamento genomico all'ospite e la grande diffusione di geni relativi ad antibiotico-resistenza, indipendentemente dall'origine del ceppo

New firm performance and territorial driving forces

The article analyses recent approaches on entry and post-entry performance by new firms, with particular focus on its applicability to small manufacturing firms recently borned in Argentina. The analysis is based on a sample of small firms created in the period 1990-2000 in three intermediate cities in Buenos Aires province (Argentina) in manufacturing sector. The survey collected data about microeconomic and mesoeconomic elements influencing firm performance. Results indicate that tradability is a key factor influencing firm performance. New firms entering markets where the spatial markets are reduced face limited perspectives on expansion. In turn, tradability is also affected by entrepeneurial motivation and, especially in underveloped regions, macroeconomic variables.new firms, post-entry performance, transability

An overview of the characterization of occupational exposure to nano aerosol in workplaces

Currently, there is a lack of standardized sampling and metric methods that can be applied to measure the level of exposure to nanosized aerosols. Therefore, any attempt to characterize exposure to nanoparticles (NP) in a workplace must involve a multifaceted approach characterized by different sampling and analytical techniques to measure all relevant characteristics of NP exposure. Furthermore, as NP aerosols are always complex mixtures of multiple origins, sampling and analytical methods need to be improved to selectively evaluate the apportionment from specific sources to the final nanomaterials. An open question at the world's level is how to relate specific toxic effects of NP with one or more among several different parameters (such as particle size, mass, composition, surface area, number concentration, aggregation or agglomeration state, water solubility and surface chemistry). As the evaluation of occupational exposure to NP in workplaces needs dimensional and chemical characterization, the main problem is the choice of the sampling and dimensional separation techniques. Therefore a convenient approach to allow a satisfactory risk assessment could be the contemporary use of different sampling and measuring techniques for particles with known toxicity in selected workplaces. Despite the lack of specific NP exposure limit values, exposure metrics, appropriate to nanoaerosols, are discussed in the Technical Report ISO/TR 27628:2007 with the aim to enable occupational hygienists to characterize and monitor nanoaerosols in workplaces. Moreover, NIOSH has developed the Document Approaches to Safe Nanotechnology (intended to be an information exchange with NIOSH) in order to address current and future research needs to understanding the potential risks that nanotechnology may have to workers. © 2009 IOP Publishing Ltd

El aprendizaje cooperativo para la mejora de los procesos educativos en un contexto de exclusión social

Premio extraordinario de Trabajo Fin de Máster curso 2015-2016. Educación Inclusiv

La motivación y el rendimiento académico en la Educación Primaria

En este trabajo de final de grado se presenta una revisión teórica que estudia el concepto de motivación y lo que envuelve a esta, abordando aspectos como los tipos de motivación existentes, los factores que influyen en esta y algunas de las teorías que han surgido alrededor de dicho concepto a lo largo de la historia. Todo ello, con el fin de buscar la relación estrecha que se da entre la motivación y el rendimiento escolar/académico. De esta manera, se centrará en estudiar cuál es el peso que tiene el factor motivacional en los resultados que el alumnado presenta, analizando a su vez tanto el rendimiento escolar/académico como los factores de los que este depende, con el objetivo de entender en qué medida el profesorado puede actuar para formar parte en el proceso de motivación de los/as estudiantes y así lograr que se muestren motivados durante el aprendizaje e incrementar su motivación intrínseca para asegurar su éxito académico y evitar fenómenos como el fracaso escolar.This final project presents a theoretical revision which studies the concept of motivation and its environment, paying attention to some of its characteristics such as its different types, the main factors that play a role on it and the variety of theories that have analyzed this concept during history. With this project we pretend to find the close relationship between motivation and the student performance at school or university. By this way, we will focus on the role that motivation plays on the student performance, analyzing not only the student performance itself but also the factors that affect it, with the aim to understand in which way teachers can take part in the students’ motivation so they can stay motivated during the learning process and increase the intrinsic motivation of them in order to achieve the academic success and avoid school failure

A Model-Based Abstraction Layer for Heterogeneous SDN Applications

Modern controllers for software-defined networks (SDN) enable the execution of arbitrary SDN applications (eg, Network Address Translation (NAT), traffic monitors) that may be exploited by an overarching set of services (eg, application-layer orchestrators) to build even richer services. To this purpose, the above overarching services require a mechanism that allows reading the run-time state and writing the configuration of arbitrary SDN applications, possibly through a uniform API. Unfortunately, most SDN applications are not designed/implemented by taking into account the possibility to be used as part of higher level service workflows (eg, a complex intrusion prevention system that leverages multiple elementary services as individual components), hence they may not provide an adequate interface that would allow overarching services to exploit their features. This paper addresses this problem by proposing an approach to represent the run-time state of arbitrary applications, where data are exported according to high-level model-based structures. Furthermore, the mapping from the high-level data model to the actual data representation within the SDN application is enabled by a suite of algorithms that are generic enough to operate independently of the actual source code of the application, thus avoiding undesired and invasive modifications to existing applications. The paper also presents a software framework and a prototype implementing the proposed approach, characterizes the resulting performance, and discusses pros and cons of the proposed approach

Role of cryptochrome-1 and cryptochrome-2 in aldosterone-producing adenomas and adrenocortical cells

Mice lacking the core-clock components, cryptochrome-1 (CRY1) and cryptochrome-2 (CRY2) display a phenotype of hyperaldosteronism, due to the upregulation of type VI 3β-hydroxyl-steroid dehydrogenase (Hsd3b6), the murine counterpart to the human type I 3β-hydroxyl-steroid dehydrogenase (HSD3B1) gene. In the present study, we evaluated the role of CRY1 and CRY2 genes, and their potential interplay with HSD3B isoforms in adrenal pathophysiology in man. Forty-six sporadic aldosterone-producing adenomas (APAs) and 20 paired adrenal samples were included, with the human adrenocortical cells HAC15 used as the in vitro model. In our cohort of sporadic APAs, CRY1 expression was 1.7-fold [0.75–2.26] higher (p = 0.016), while CRY2 showed a 20% lower expression [0.80, 0.52–1.08] (p = 0.04) in APAs when compared with the corresponding adjacent adrenal cortex. Type II 3β-hydroxyl-steroid dehydrogenase (HSD3B2) was 317-fold [200–573] more expressed than HSD3B1, and is the main HSD3B isoform in APAs. Both dehydrogenases were more expressed in APAs when compared with the adjacent cortex (5.7-fold and 3.5-fold, respectively, p < 0.001 and p = 0.001) and HSD3B1 was significantly more expressed in APAs composed mainly of zona glomerulosa-like cells. Treatment with angiotensin II (AngII) resulted in a significant upregulation of CRY1 (1.7 ± 0.25-fold, p < 0.001) at 6 h, and downregulation of CRY2 at 12 h (0.6 ± 0.1-fold, p < 0.001), through activation of the AngII type 1 receptor. Independent silencing of CRY1 and CRY2 genes in HAC15 cells resulted in a mild upregulation of HSD3B2 without affecting HSD3B1 expression. In conclusion, our results support the hypothesis that CRY1 and CRY2, being AngII-regulated genes, and showing a differential expression in APAs when compared with the adjacent adrenal cortex, might be involved in adrenal cell function, and in the regulation of aldosterone production

Spontaneous low-protein intake in older CKD patients: one diet may not fit all

BackgroundProtein restriction has been extended to stage 3 chronic kidney disease (CKD) regardless of age in the latest K-DOQI guidelines for the dietary management of patients with CKD. However, in elderly CKD patients there is a tendency to a spontaneous reduction in protein and energy intake that may impair the overall nutritional status. The aim of our study is to assess whether there are differences in malnutrition, exercise capacity and inflammatory status in elderly CKD patients with spontaneously low protein intake (sLPI) compared with patients with normal protein intake (NPI).MethodsWe performed a cross-sectional analysis of 123 incident patients. Malnutrition was assessed using Malnutrition Inflammation Score (MIS) and serum markers; As for physical performance, we used Short Physical Performance Battery (SPPB) and handgrip strength.ResultsWe found that in older patients with advanced CKD, as many as 68% had low spontaneous protein intake, and they were more malnourished evaluated with MIS (25% vs. 10%, p = 0.033), protein-energy wasting (PEW) (43% vs. 14%, p = 0.002) and nPCR (0.63[0.51–0.69] vs. 0.95[0.87–1.1], p < 0.0001). They also had worse body composition, in terms of lower mid-arm muscular circumference (MAMC), fat tissue index (FTI) and higher overhydration (OH). sLPI patients also had higher levels of IL6 (4.6[2.9–8.9] vs. 2.8[0.8–5.1], p = 0.002). Moreover, sLPI patients were frailer (33% vs. 24%, p = 0.037) and had poorer physical performance especially when assessed with (SPPB) (7[5–9] vs. 9[7–10], p = 0.004) and gait test time (6.08 + 2 vs. 7.22 + 2.7, p = 0.04). sLPI was associated with lower physical performance [SPPB OR, 0.79 (0.46–0.97), p = 0.046] and malnutrition [MIS 1.6 (1.05–3.5), p = 0.041] independently from patients’ age and eGFR.ConclusionWe found that in older patients with advanced CKD, up to 68% had low spontaneous protein intake and were frailer, more malnourished and with lower physical performance. These findings emphasize the importance of assessing patients’ needs, and personalized approaches with individual risk–benefit assessments should be sought. To achieve the best possible outcomes, targeted interventions should use all available tools