Modulation of human corticospinal excitability by paired associative stimulation

Paired Associative Stimulation (PAS) has come to prominence as a potential therapeutic intervention for the treatment of brain injury/disease, and as an experimental method with which to investigate Hebbian principles of neural plasticity in humans. Prototypically, a single electrical stimulus is directed to a peripheral nerve in advance of transcranial magnetic stimulation (TMS) delivered to the contralateral primary motor cortex (M1). Repeated pairing of the stimuli (i.e., association) over an extended period may increase or decrease the excitability of corticospinal projections from M1, in manner that depends on the interstimulus interval (ISI). It has been suggested that these effects represent a form of associative long-term potentiation (LTP) and depression (LTD) that bears resemblance to spike-timing dependent plasticity (STDP) as it has been elaborated in animal models. With a large body of empirical evidence having emerged since the cardinal features of PAS were first described, and in light of the variations from the original protocols that have been implemented, it is opportune to consider whether the phenomenology of PAS remains consistent with the characteristic features that were initially disclosed. This assessment necessarily has bearing upon interpretation of the effects of PAS in relation to the specific cellular pathways that are putatively engaged, including those that adhere to the rules of STDP. The balance of evidence suggests that the mechanisms that contribute to the LTP- and LTD-type responses to PAS differ depending on the precise nature of the induction protocol that is used. In addition to emphasizing the requirement for additional explanatory models, in the present analysis we highlight the key features of the PAS phenomenology that require interpretation

Upper Surface Nacelle Influence on SCAR Aerodynamic Characteristics at Transonic Speeds

The arrow-wing transport configuration with detached engines located over the wing to produce upper surface exhaust flow effects was tested at angles of attack from -4 deg to 8 deg and jet total-pressure ratios from 1 (Jet off) to approximately 10. Wing tip leading edge flap deflections of -10 deg to 10 deg were tested with the wing-body configuration only (no nacelles). Tests were made with various nacelle chordwise, spanwise, and vertical height locations over the Mach number, angle of attack, and jet total-pressure ratio ranges. Deflecting the wing tip leading edge flap from 0 deg to -10 deg increased maximum lift to drag ratio by 1.0 at subsonic speeds. Installation of upper surface nacelles (no wing/nacelle pylons) increased the wing-body pitching moment at all Mach numbers and decreased the drag of the wing-body configuration at subsonic Mach numbers. Jet exhaust interference effects were negligible

Transonic aerodynamic characteristics of a supersonic cruise aircraft research model with the engines suspended above the wing

The influence of upper-surface nacelle exhaust flow on the aerodynamic characteristics of a supersonic cruise aircraft research configuration was investigated in a 16 foot transonic tunnel over a range of Mach numbers from 0.60 to 1.20. The arrow-wing transport configuration with engines suspended over the wing was tested at angles of attack from -4 deg to 6 deg and jet total pressure ratios from 1 to approximately 13. Wing-tip leading edge flap deflections of -10 deg to 10 deg were tested with the wing-body configuration. Various nacelle locations (chordwise, spanwise, and vertical) were tested over the ranges of Mach numbers, angles of attack, and jet total-pressure ratios. The results show that reflecting the wing-tip leading edge flap from 0 deg to -10 deg increased the maximum lift-drag ratio by 1.0 at subsonic speeds. Jet exhaust interference effects were negligible

Experimental and analytical investigation of axisymmetric supersonic cruise nozzle geometry at Mach numbers from 0.60 to 1.30

Quantitative pressure and force data for five axisymmetric boattail nozzle configurations were examined. These configurations simulate the variable-geometry feature of a single nozzle design operating over a range of engine operating conditions. Five nozzles were tested in the Langley 16-Foot Transonic Tunnel at Mach numbers from 0.60 to 1.30. The experimental data were also compared with theoretical predictions

Particle sizing in the process industry using Hertz-Zener impact theory and acoustic emission spectra

The cost of implementing real-time monitoring and control of industrial processes is a significant barrier for many companies. Acoustic techniques provide complementary information to optical spectroscopic sensors and have a number of advantages: they are relatively inexpensive, can be applied non-invasively, are non-destructive, multi-point measurements are possible, opaque samples can be analysed in containers that are made from opaque materials (e.g. steel or concrete) and the analysis can be conducted in real-time. In this paper a new theoretical model is proposed which describes the transport of particles in a stirred reactor, their collision with the reactor walls, the subsequent vibrations which are then transmitted through the vessel walls, and their detection by an ultrasonic transducer. The particle-wall impact is modelled using Hertz-Zener impact theory. Experimental data is then used in conjunction with this (forward) model to form an inverse problem for the particle size distribution using a least squares cost function. Application of an integral smoothing operator to the power spectra greatly enhances the accuracy and robustness of the approach. One advantage of this new approach is that since it operates in the frequency domain, it can cope with the industrially relevant case of many particle-wall collisions. The technique will be illustrated using data from a set of controlled experiments. In the first instance a set of simplified experiments involving single particles being dropped in air onto a substrate are utilised. The second set of experiments involves particles in a carrier fluid being stirred in a reactor vessel. In each case the approach is able to successfully recover the associated particle size

Performance of a building integrated photovoltaic/thermal (BIPVT) solar collector

The idea of combining photovoltaic and solar thermal collectors (PVT collectors) to provide electrical and heat energy is an area that has, until recently, received only limited attention. Although PVTs are not as prevalent as solar thermal systems, the integration of photovoltaic and solar thermal collectors into the walls or roofing structure of a building could provide greater opportunity for the use of renewable solar energy technologies. In this study, the design of a novel building integrated photovoltaic/thermal (BIPVT) solar collector was theoretically analysed through the use of a modified Hottel–Whillier model and was validated with experimental data from testing on a prototype BIPVT collector. The results showed that key design parameters such as the fin efficiency, the thermal conductivity between the PV cells and their supporting structure, and the lamination method had a significant influence on both the electrical and thermal efficiency of the BIPVT. Furthermore, it was shown that the BIPVT could be made of lower cost materials, such as pre-coated colour steel, without significant decreases in efficiency. Finally, it was shown that by integrating the BIPVT into the building rather than onto the building could result in a lower cost system. This was illustrated by the finding that insulating the rear of the BIPVT may be unnecessary when it is integrated into a roof above an enclosed air filled attic, as this air space acts as a passive insulating barrier