Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells.

Plasmalemma vesicle associated protein (Plvap) is an endothelial protein with roles in endothelial diaphragm formation and maintenance of basal vascular permeability. At the same time Plvap has roles in immunity by facilitating leukocyte diapedesis at inflammatory sites and controlling peripheral lymph node morphogenesis and the entry of soluble antigens into lymph node conduits. Based on its postulated role in diapedesis, we have investigated the role of Plvap in hematopoiesis and show that deletion of Plvap results in a dramatic decrease of IgM(+)IgD(lo) B cells in both the spleen and peritoneal cavity. Tissue specific deletion of Plvap demonstrates that the defect is B cell extrinsic, as B cell and pan hematopoietic Plvap deletion has no effect on IgM(+)IgD(lo) B cell numbers. Endothelial specific deletion of Plvap in the embryo or at adult stage recapitulates the full Plvap knockout phenotype whereas endothelial specific reconstitution of Plvap under the Chd5 promoter rescues the IgM(+)IgD(lo) B cell phenotype. Taken together, these results show that Plvap expression in endothelial cells is important in the maintenance of IgM(+) B cells in the spleen and peritoneal cavity

Reporting comptable et financier des sociétés: Comprendre, interpréter et analyser l'information

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Special Issue on the “Regulation and Physiopathology of the Gut Barrier”

The importance of gut barrier integrity in intestinal homeostasis and the consequences of its alteration in the etiology of human pathologies have been subjects of exponentially growing interest during the last decade [...

Special Issue on the “Regulation and Physiopathology of the Gut Barrier”

The importance of gut barrier integrity in intestinal homeostasis and the consequences of its alteration in the etiology of human pathologies have been subjects of exponentially growing interest during the last decade [...

Le reporting financier des Associations de solidarité internationale (ASI) françaises sur le Web L’influence de l’usage des fonds collectés

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Reporting comptable et financier des sociétés: Comprendre, interpréter et analyser l'information

International audienc

Reporting comptable et financier des sociétés: Comprendre, interpréter et analyser l'information

International audienc

Le reporting financier des Associations de solidarité internationale (ASI) françaises sur le Web L’influence de l’usage des fonds collectés

International audienc