79 research outputs found
Nurses Alumni Association Bulletin, Fall 1987
Alumni Calendar
Officers and Committee Chairmen
The President\u27s Message
Treasurer\u27s Report
Nurses\u27 Relief Fund
Scholarship Fund
School Nurses- Ahead of Their Time
Remember?
Happy Ending
Florence Nightingale
End of an Era
Little Jeff - As I Remember It
Happy Retirement Peg
Distinguished Career Ends
Special Achievement Award
Fiftieth Anniversary
1986 Alumni Directory
Happy Birthday
Resume of Minutes of Alumni Association Meetings
Bequests
Alumni Office News
Committee Reports Bulletin
Scholarship
Satellite
Social
Finance
Luncheon Pictures
In Memoriam, Names of Deceased Graduates
Class News
Caps, Pins, Transcripts, Class Address Lists
Change of Address Form
Relief Fund Application
Scholarship Fund Application
Membership Applicatio
The Bulletin, School of Nursing Alumni Association, 1978
Alumni Calendar
Recognition Plaque
A Letter from the President
Officers and Chairpersons
Jefferson - Past, Present and Future
Annual Reports
School of Practical Nursing
Sesqui Pledge Completed
Alumnae Data 1891-1978
Committee Reports
A.N.A. Convention Report
The Liberation of a POW
Resume of Alumni Meetings
Cocktails and Conversation
Class News
Luncheon Gusts - Class of 1978
Marriages
Births
In Memoriam
Alumni Notices
School of Nursing Notice
Alumni Association Bulletin of the School of Nursing, 1976
Alumni Calendar
The President\u27s Message
Officers and Chairpersons of Committees
Financial Report
Annual Reports
New Surgical Concept for Laryngeal Cancer
Computerized Transaxial X-ray Scanner
Dental Health Center
The Winged Ox of St. Luke
Pictures - New Building
Committee Reports
Resume of Alumni Minutes
Ways and Means Report
Alumni News
Class News
Names and Addresses of 1976 Graduates
School of Nursing 1976 Awards
Marriages
Births
In Memoriam - List of Alumni
In Memoriam - Dr. Peter A. Herbut
In Memoriam - Miss Katherine Childs
Change of Address Notice
Notice
The Bulletin, School of Nursing Alumnae Association, 1977
A Letter from the President
Progress - The New Jefferson Hospital/Clinical Teaching Facility 1977
School of Nursing
A Comprehensive Approach to Hand Rehabilitation
Parking Garage
Your Sesquicentennial Campaign
Social Report
Scholarship Report
Sick and Welfare Committee
Program Committee
Resource Committee of the Board of Trustees
Bulletin
Administration
Ways and Means Committee Report
Resume of Minutes of Alumnae Association Meetings
Duke University Distinguished Alumna Award to Col. Catherine T. Betz (Ret.)
Patient Representatives
The Joys and Sorrows of a Director of Geriatric Nursing
Highlights 1976 P.N.A Convention
Class News
Marriages
Births
In Memoriam
A Letter from the Former President
Help Us - Help Yo
Circulating αKlotho influences phosphate handling by controlling FGF23 production
The FGF23 coreceptor αKlotho (αKL) is expressed as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signaling. It also circulates as an endoproteolytic cleavage product of mKL (cKL). Previously, a patient with increased plasma cKL as the result of a translocation [t(9;13)] in the αKLOTHO (KL) gene presented with rickets and a complex endocrine profile, including paradoxically elevated plasma FGF23, despite hypophosphatemia. The goal of this study was to test whether cKL regulates phosphate handling through control of FGF23 expression. To increase cKL levels, mice were treated with an adeno-associated virus producing cKL. The treated groups exhibited dose-dependent hypophosphatemia and hypocalcemia, with markedly elevated FGF23 (38 to 456 fold). The animals also manifested fractures, reduced bone mineral content, expanded growth plates, and severe osteomalacia, with highly increased bone Fgf23 mRNA (>150 fold). cKL activity in vitro was specific for interactions with FGF23 and was FGFR dependent. These results demonstrate that cKL potently stimulates FGF23 production in vivo, which phenocopies the KL translocation patient and metabolic bone syndromes associated with elevated FGF23. These findings have important implications for the regulation of αKL and FGF23 in disorders of phosphate handling and biomineralization
Status of Muon Collider Research and Development and Future Plans
The status of the research on muon colliders is discussed and plans are
outlined for future theoretical and experimental studies. Besides continued
work on the parameters of a 3-4 and 0.5 TeV center-of-mass (CoM) energy
collider, many studies are now concentrating on a machine near 0.1 TeV (CoM)
that could be a factory for the s-channel production of Higgs particles. We
discuss the research on the various components in such muon colliders, starting
from the proton accelerator needed to generate pions from a heavy-Z target and
proceeding through the phase rotation and decay ()
channel, muon cooling, acceleration, storage in a collider ring and the
collider detector. We also present theoretical and experimental R & D plans for
the next several years that should lead to a better understanding of the design
and feasibility issues for all of the components. This report is an update of
the progress on the R & D since the Feasibility Study of Muon Colliders
presented at the Snowmass'96 Workshop [R. B. Palmer, A. Sessler and A.
Tollestrup, Proceedings of the 1996 DPF/DPB Summer Study on High-Energy Physics
(Stanford Linear Accelerator Center, Menlo Park, CA, 1997)].Comment: 95 pages, 75 figures. Submitted to Physical Review Special Topics,
Accelerators and Beam
Colorectal Cancer in Patients Under Close Colonoscopic Surveillance
BACKGROUND & AIMS: Colonoscopic polypectomy is considered effective for preventing colorectal cancer (CRC), but the incidence of cancer in patients under colonoscopic surveillance has rarely been investigated. We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and adenoma with high-grade dysplasia.
METHODS: Patients were drawn from 3 adenoma chemoprevention trials. All underwent baseline colonoscopy with removal of at least one adenoma and were deemed free of remaining lesions. We identified patients subsequently diagnosed with invasive cancer or adenoma with high-grade dysplasia. The timing, location, and outcome of all cases of cancer and high-grade dysplasia identified are described and risks associated with their development explored.
RESULTS: CRC was diagnosed in 19 of the 2915 patients over a mean follow-up of 3.7 years (incidence, 1.74 cancers/1000 person-years). The cancers were located in all regions of the colon; 10 were at or proximal to the hepatic flexure. Although most of the cancers (84%) were of early stage, 2 participants died of CRC. Seven patients were diagnosed with adenoma with high-grade dysplasia during follow-up. Older patients and those with a history of more adenomas were at higher risk of being diagnosed with invasive cancer or adenoma with high-grade dysplasia.
CONCLUSIONS: CRC is diagnosed in a clinically important proportion of patients following complete colonoscopy and polypectomy. More precise and representative estimates of CRC incidence and death among patients undergoing surveillance examinations are needed
A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas
Epidemiologic and preclinical data suggest that higher intake and serum levels of vitamin D and higher intake of calcium reduce the risk of colorectal neoplasia. To further study the chemopreventive potential of these nutrients, we conducted a randomized, double-blind, placebo-controlled trial of supplementation with vitamin D, calcium, or both for the prevention of colorectal adenomas
The Early Royal Society and Visual Culture
Recent studies have fruitfully examined the intersection between early modern science and visual culture by elucidating the functions of images in shaping and disseminating scientific knowledge. Given its rich archival sources, it is possible to extend this line of research in the case of the Royal Society to an examination of attitudes towards images as artefacts –manufactured objects worth commissioning, collecting and studying. Drawing on existing scholarship and material from the Royal Society Archives, I discuss Fellows’ interests in prints, drawings, varnishes, colorants, images made out of unusual materials, and methods of identifying the painter from a painting. Knowledge of production processes of images was important to members of the Royal Society, not only as connoisseurs and collectors, but also as those interested in a Baconian mastery of material processes, including a “history of trades”. Their antiquarian interests led to discussion of painters’ styles, and they gradually developed a visual memorial to an institution through portraits and other visual records.AH/M001938/1 (AHRC
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