The substantia Nigra pars compacta and temporal processing

The basal ganglia and cerebellum are considered to play a role in timing, although their differential roles in timing remain unclear. It has been proposed that the timing of short milliseconds-range intervals involves the cerebellum, whereas longer seconds-range intervals engage the basal ganglia (Ivry, 1996). We tested this hypothesis using positron emission tomography to measure regional cerebral blood flow in eight right-handed males during estimation and reproduction of long and short intervals. Subjects performed three tasks: (1) reproduction of a short 500 ms interval, (2) reproduction of a long 2 s interval, and (3) a control simple reaction time (RT) task. We compared the two time reproduction tasks with the control RT task to investigate activity associated with temporal processing once additional cognitive, motor, or sensory processing was controlled. We found foci in the left substantia nigra and the left lateral premotor cortex to be significantly more activated in the time reproduction tasks than the control RT task. The left caudate nucleus and right cerebellum were more active in the short relative to the long interval, whereas greater activation of the right putamen and right cerebellum occurred in the long rather than the short interval. These results suggest that the basal ganglia and the cerebellum are engaged by reproduction of both long and short intervals but play different roles. The fundamental role of the substantia nigra in temporal processing is discussed in relation to previous animal lesion studies and evidence for the modulating influence of dopamine on temporal processing

Carbon sequestration and biogeochemical cycling in a saltmarsh subject to coastal managed realignment

Globally, wetlands provide the largest terrestrial carbon (C) store, and restoration of degraded wetlands provides a potentially important mechanism for climate change mitigation. We examined the potential for restored saltmarshes to sequester carbon, and found that they can provide a modest, but sustained, sink for atmospheric CO2. Rates of C and nutrient cycling were measured and compared between a natural saltmarsh (high- and low-shore locations), claimed arable land on former high-shore saltmarsh and a managed realignment restoration site (high- and low-shore) in transition from agricultural land to saltmarsh 15 years after realignment, at Tollesbury, Essex, UK. We measured pools and turnover of C and nitrogen (N) in soil and vegetation at each site using a range of methods, including gas flux measurement and isotopic labelling. The natural high-shore site had the highest soil organic matter concentrations, topsoil C stock and below-ground biomass, whereas the agricultural site had the highest total extractable N concentration and lowest soil C/N ratio. Ecosystem respiration rates were similar across all three high-shore sites, but much higher in both low-shore sites, which receive regular inputs of organic matter and nutrients from the estuary. Total evolution of 14C-isotopically labelled substrate as CO2 was highest at the agricultural site, suggesting that low observed respiration rates here were due to low substrate supply (following a recent harvest) rather than to inherently low microbial activity. The results suggest that, after 15 years, the managed realignment site is not fully equivalent to the natural saltmarsh in terms of biological and chemical function. While above ground biomass, extractable N and substrate mineralisation rates in the high-shore site were all quite similar to the natural site, less dynamic ecosystem properties including soil C stock, C/N ratio and below-ground biomass all remained more similar to the agricultural site. These results suggest that reversion to natural biogeochemical functioning will occur following restoration, but is likely to be slow; we estimate that it will take approximately 100 years for the restored site to accumulate the amount of C currently stored in the natural site, at a rate of 0.92 t C ha−1 yr−1

On Nucleon Electromagnetic Form Factors: A Pre'cis

Electron scattering at large Q^2 probes a nucleon's quark core. This core's contribution to electromagnetic form factors may be calculated using Poincare' covariant Faddeev amplitudes combined with a nucleon-photon vertex that automatically fulfills a Ward-Takahashi identity for on-shell nucleons. The calculated behaviour of G_E^p(Q^2)/G_M^p(Q^2) on 2<Q^2(GeV^2)<6 agrees with that inferred from polarisation transfer data, and exhibits a zero at Q^2\approx 6.5 GeV^2. There is some evidence that F_2(Q^2)/F_1(Q^2) \propto [\ln(Q^2/\Lambda^2)]^2/Q^2 for Q^2>6 GeV^2.Comment: Contribution to the proceedings of "Baryons 04," the 10th International Conference on the Structure of Baryons, 25-29/Oct./04, Ecole Polytechnique, Palaiseau; 5 pages, 3 figure

A hybrid multiagent approach for global trajectory optimization

In this paper we consider a global optimization method for space trajectory design problems. The method, which actually aims at finding not only the global minimizer but a whole set of low-lying local minimizers(corresponding to a set of different design options), is based on a domain decomposition technique where each subdomain is evaluated through a procedure based on the evolution of a population of agents. The method is applied to two space trajectory design problems and compared with existing deterministic and stochastic global optimization methods

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)-6, are elevated in IPF, the molecular mechanisms that underlie this disease are incompletely understood, although the development of fibrosis is believed to depend on canonical transforming growth factor (TGF)-β signalling. We examined bleomycin-induced inflammation and fibrosis in mice carrying a mutation in the shared IL-6 family receptor gp130. Using genetic complementation, we directly correlate the extent of IL-6-mediated, excessive Stat3 activity with inflammatory infiltrates in the lung and the severity of fibrosis in corresponding gp130757F mice. The extent of fibrosis was attenuated in B lymphocyte-deficient gp130757F;µMT−/− compound mutant mice, but fibrosis still occurred in their Smad3−/− counterparts consistent with the capacity of excessive Stat3 activity to induce collagen 1α1 gene transcription independently of canonical TGF-β/Smad3 signalling. These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis

The genetic basis of larval resistance to a host plant toxin in Drosophila sechellia

The larvae of Drosophila sechellia are highly resistant to octanoic acid, a toxin found in D. sechellia's host plant, Morinda citrifolia. In contrast, close relatives of D. sechellia, D. simulans and D. melanogaster, are not resistant. In a series of interspecific backcrosses, 11 genetic markers were used to map factors affecting egg-to-adult ('larval') resistance in D. sechellia. The third chromosome harbours at least one partially dominant resistance factor. The second chromosome carries at least two mostly dominant resistance factors but no recessive factors. However, neither the X chromosome - which contains 20% of D. sechellia's genome - nor the fourth chromosome appear to affect resistance. These data suggest that larval resistance to Morinda toxin may involve only a handful of genes. These results, when compared with a previous analysis of adult resistance to Morinda toxin in D. sechellia, suggest that larval resistance may involve a subset of the genes underlying adult resistance

Tkachenko waves, glitches and precession in neutron star

Here I discuss possible relations between free precession of neutron stars, Tkachenko waves inside them and glitches. I note that the proposed precession period of the isolated neutron star RX J0720.4-3125 (Haberl et al. 2006) is consistent with the period of Tkachenko waves for the spin period 8.4s. Based on a possible observation of a glitch in RX J0720.4-3125 (van Kerkwijk et al. 2007), I propose a simple model, in which long period precession is powered by Tkachenko waves generated by a glitch. The period of free precession, determined by a NS oblateness, should be equal to the standing Tkachenko wave period for effective energy transfer from the standing wave to the precession motion. A similar scenario can be applicable also in the case of the PSR B1828-11.Comment: 6 pages, no figures, accepted to Ap&S

Unification through extra dimensions at two loops

The presence of an extra dimension of size R\equiv M_c^{-1} introduces corrections of order (\mu/M_c)\alpha to the gauge and Yukawa couplings and accelerates their running at scales \mu larger than M_c. This could result in a grand unification scale M_X\approx 20 M_c. We study the corrections at the two-loop level. We find corrections of order (\mu/M_c)\alpha^2 for the gauge couplings and of order (\mu/M_c)^2\alpha^2 for the Yukawa couplings. Therefore, in the Yukawa sector one and two-loop contributions can be of the same order below M_X. We show that in the usual scenarios the dominant gauge and Yukawa couplings are decreasing functions of the scale, in such a way that (\mu/M_c)\alpha becomes approximately constant and two-loop contributions introduce just a 30% correction which does not increase with the scale.Comment: 14 pages, added references, corrected typo

Commissioning of the CMS High Level Trigger

The CMS experiment will collect data from the proton-proton collisions delivered by the Large Hadron Collider (LHC) at a centre-of-mass energy up to 14 TeV. The CMS trigger system is designed to cope with unprecedented luminosities and LHC bunch-crossing rates up to 40 MHz. The unique CMS trigger architecture only employs two trigger levels. The Level-1 trigger is implemented using custom electronics, while the High Level Trigger (HLT) is based on software algorithms running on a large cluster of commercial processors, the Event Filter Farm. We present the major functionalities of the CMS High Level Trigger system as of the starting of LHC beams operations in September 2008. The validation of the HLT system in the online environment with Monte Carlo simulated data and its commissioning during cosmic rays data taking campaigns are discussed in detail. We conclude with the description of the HLT operations with the first circulating LHC beams before the incident occurred the 19th September 2008