1 research outputs found
Enantioselective Synthesis of Chiral Sulfones by Ir-Catalyzed Asymmetric Hydrogenation: A Facile Approach to the Preparation of Chiral Allylic and Homoallylic Compounds
A highly efficient and enantioselective Ir-catalyzed
hydrogenation
of unsaturated sulfones was developed. Chiral cyclic and acyclic sulfones
were produced in excellent enantioselectivities (up to 98% ee). Coupled
with the Ramberg–Bäcklund rearrangement, this reaction
offers a novel route to chiral allylic and homoallylic compounds in
excellent enantioselectivities (up to 97% ee) and high yields (up
to 94%)